Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mario Callejo"'
Autor:
Samira Merali, Zhaoqing Wang, Charles Frost, Mario Callejo, Michael Hedrick, Lester Hui, Stephanie Meadows Shropshire, Ke Xu, Michel Bouvier, Mary M. DeSouza, Jing Yang
Publikováno v:
Platelets, Vol 33, Iss 7, Pp 969-978 (2022)
BMS-986120 is a novel first-in-class oral protease-activated receptor 4 (PAR4) antagonist exhibiting robust antithrombotic activity that has shown low bleeding risk in monkeys. We sought to assess pharmacokinetics, pharmacodynamics, and tolerability
Externí odkaz:
https://doaj.org/article/47ad41e68b7743679c9d02c11b017d54
Autor:
E. Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Julia Guy, Philippe Lapointe, Jean-François Lavallée, Alain Martel, Serge Plamondon, Roger Rémillard, Edward Ruediger, François Tremblay, Shana L. Posy, Victor R. Guarino, Jeremy M. Richter, Jianqing Li, Anuradha Gupta, Muthalagu Vetrichelvan, T. J. Balapragalathan, Arvind Mathur, Ji Hua, Mario Callejo, Jocelyne Guay, Chi Shing Sum, Mary Ellen Cvijic, Carol Watson, Pancras Wong, Jing Yang, Michel Bouvier, David A. Gordon, Ruth R. Wexler, Anne Marinier
Publikováno v:
Journal of Medicinal Chemistry. 65:8843-8854
Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin. PAR4 plays a key role in blood coagulation, and its importance in pathological thrombosis has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92102691c8abe2b69e4c2ddc373e653f
https://doi.org/10.1021/acs.jmedchem.2c00359
https://doi.org/10.1021/acs.jmedchem.2c00359
Autor:
William A. Schumacher, Jocelyne Guay, J.Eileen Bird, David A. Gordon, Mary Giancarli, Ruth R. Wexler, Pancras C. Wong, Mario Callejo, Michael M. Miller, Carol A. Watson, Julia Guy, Anne Marinier, Brad D. Maxwell, Ji Hua, E. Scott Priestley, Dietmar A. Seiffert, David G. Harden, Michel Bouvier, R. Michael Lawrence, Jacques Banville, Jing Yang, Nick J. Allegretto, Jeffrey S. Bostwick
Publikováno v:
Science translational medicine. 9(371)
Antiplatelet agents are proven efficacious treatments for cardiovascular and cerebrovascular diseases. However, the existing drugs are compromised by unwanted and sometimes life-threatening bleeding that limits drug usage or dosage. There is a substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d427e379afff9473a9e5e545b39ec1
https://pubmed.ncbi.nlm.nih.gov/29610748
https://pubmed.ncbi.nlm.nih.gov/29610748
Autor:
Scott Priestley, Jeffrey Colin, Xuewen Ma, Michel Bouvier, Jacques Banville, Sophie Desmeules, Anne Marinier, Roger Remillard, Fraz A. Ismat, Mario Callejo, Ke Xu, Tao Wang, John N. Feder, Zhaoqing Wang, Gabe Mintier, Chi Sum, Jing Yang
Publikováno v:
Stroke. 47
Introduction: Protease-activated receptor 4 (PAR4) is a platelet thrombin receptor and a novel target for ischemic stroke treatment. Recent reports suggested a subtle racial difference in platelet responses to submaximal concentrations of PAR4 agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ec8e0dcbf07ea72baba95a95e1e2156
https://doi.org/10.1161/str.47.suppl_1.wp263
https://doi.org/10.1161/str.47.suppl_1.wp263
Autor:
María Eugenia Ferro Moreira, Norberto Miranda Espinosa, Julio Diego Olivera Salgado, Mario Callejo Hernández
Publikováno v:
Revista Cubana de Pediatría, Vol 83, Iss 1, Pp 14-21 (2011)
INTRODUCCIÓN. El bazo es el órgano que más frecuentemente se lesiona en los traumatismos abdominales. Fueron objetivos de este trabajo describir la conducta conservadora ante el traumatismo esplénico y determinar su frecuencia en el Hospital Pedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::a5b23d6b2eb376815848fa4c01d831fe
http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312011000100002&lng=en&tlng=en
http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312011000100002&lng=en&tlng=en
Publikováno v:
Trends in Biochemical Sciences. 33:44-50
Cruciforms are secondary DNA structures, serving as recognition signals at or near eukaryotic (yeast and mammalian) origins of DNA replication. The cruciform-binding protein is a member of the 14-3-3 protein family and binds to origins of DNA replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e93c63946f7f4b0b52de365ca145497
https://doi.org/10.1016/j.tibs.2007.09.012
https://doi.org/10.1016/j.tibs.2007.09.012
Autor:
Luis A. Rokeach, Pierre-Luc Tanguay, Renée Guérin, Alexandre Maréchal, Guy Boileau, Mario Callejo
Publikováno v:
Biochemical Journal. 380:441-448
Folding of newly synthesized proteins within the ER (endoplasmic reticulum) is a rate-limiting step in protein secretion. Thus ER molecular chaperones and foldases have a major impact in determining the rate and yield of these crucial cellular proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2574a6a029a7bb0b83a8ee41abaeaec8
https://doi.org/10.1042/bj20031546
https://doi.org/10.1042/bj20031546
Autor:
John S. McCarty, Mohammed Dehbi, Greg Moeck, Tony Kwan, Daniel M. Williams, Jerry Pelletier, Vincent Ferretti, Mario Callejo, Francis F. Arhin, Ramakrishnan Srikumar, Michael S. DuBow, Philippe Gros, Pascale Bauda, Jinzi J Wu, Nhuan Ha, Dominique Bergeron, Jing Liu
Publikováno v:
Nature Biotechnology. 22:185-191
Over evolutionary time bacteriophages have developed unique proteins that arrest critical cellular processes to commit bacterial host metabolism to phage reproduction. Here, we apply this concept of phage-mediated bacterial growth inhibition to antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9dbd7cfe094f961e40a867ff3cab139
https://doi.org/10.1038/nbt932
https://doi.org/10.1038/nbt932
Publikováno v:
Biochemistry. 37:17253-17261
The association of newly synthesized glycoproteins with the ER molecular chaperones calnexin and immunoglobulin binding protein (BiP) has been well documented in a variety of higher eukaryotes. Here we report that Cnx1p, the calnexin homologue in Sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef33ab438ab3b1a41ad486cd678f5d13
https://doi.org/10.1021/bi981785c
https://doi.org/10.1021/bi981785c
Publikováno v:
Journal of cellular biochemistry. 99(6)
We previously isolated from African green monkey (CV-1) cells a replication origin, ors8, that is active at the onset of S-phase. Here, its homologous sequence (hors8, accession number: DQ230978) was amplified from human cells, using the monkey-ors8-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fc090700befaa70ce3750d450ff5f8
https://pubmed.ncbi.nlm.nih.gov/16823771
https://pubmed.ncbi.nlm.nih.gov/16823771