Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mario C. Chang"'
Autor:
Marc McLeod, Mario C. Chang, Anna Rushin, Mukundan Ragavan, Rohit Mahar, Gaurav Sharma, Arshee Badar, Anthony Giacalone, Max E. Glanz, Vinay R. Malut, Dalton Graham, Nishanth E. Sunny, James A. Bankson, Kenneth Cusi, Matthew E. Merritt
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101714- (2024)
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe
Externí odkaz:
https://doaj.org/article/c5f37c219a1342b59cc8a63717b98100
Autor:
Stephen J. Staklinski, Mario C. Chang, Rebecca C. Ahrens‐Nicklas, Shagun Kaur, Arianna K. Stefanatos, Elizabeth E. Dudenhausen, Matthew E. Merritt, Michael S. Kilberg
Publikováno v:
JIMD Reports, Vol 64, Iss 2, Pp 167-179 (2023)
Abstract Asparagine synthetase (ASNS) catalyzes the synthesis of asparagine (Asn) from aspartate and glutamine. Biallelic mutations in the ASNS gene result in ASNS Deficiency (ASNSD). Children with ASNSD exhibit congenital microcephaly, epileptic‐l
Externí odkaz:
https://doaj.org/article/43ff810be89c4f6e9718627d28111f9a
Autor:
Rohit Mahar, Mukundan Ragavan, Mario C. Chang, Savannah Hardiman, Nissin Moussatche, Adam Behar, Rolf Renne, Matthew E. Merritt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has not been extensively studied. In this work,
Externí odkaz:
https://doaj.org/article/73e20652647c43a6985afe9e06614b7e
Autor:
Mario C. Chang, Stephen J. Staklinski, Vinay R. Malut, Geraldine L. Pierre, Michael S. Kilberg, Matthew E. Merritt
Publikováno v:
Nutrients, Vol 15, Iss 8, p 1938 (2023)
The natural amino acid asparagine (Asn) is required by cells to sustain function and proliferation. Healthy cells can synthesize Asn through asparagine synthetase (ASNS) activity, whereas specific cancer and genetically diseased cells are forced to o
Externí odkaz:
https://doaj.org/article/f653038ae3664b4086337de6022f7344
Autor:
Mario C. Chang, Rohit Mahar, Marc A. McLeod, Anthony G. Giacalone, Xiumei Huang, David A. Boothman, Matthew E. Merritt
Publikováno v:
Nutrients, Vol 14, Iss 15, p 3020 (2022)
The compound β-lapachone, a naturally derived naphthoquinone, has been utilized as a potent medicinal nutrient to improve health. Over the last twelve years, numerous reports have demonstrated distinct associations of β-lapachone and NAD(P)H: quino
Externí odkaz:
https://doaj.org/article/29b1ea1f65ac47e59e40de7f8fb70257
Autor:
Jiajun Lei, Rohit Mahar, Mario C. Chang, James Collins, Matthew E. Merritt, Timothy J. Garrett, Richard A. Yost
Publikováno v:
Analytical Chemistry. 95:1908-1915
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ecc9e6f2fdfc26659c9b35d3cae5b10
https://doi.org/10.1021/acs.analchem.2c03974
https://doi.org/10.1021/acs.analchem.2c03974
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0aee96841c1c8ae18e711ee4041b496
https://doi.org/10.1096/fasebj.2022.36.s1.r5145
https://doi.org/10.1096/fasebj.2022.36.s1.r5145
Autor:
Stephen J. Staklinski, Mario C. Chang, Fang Yu, Kathleen Collins Ruff, David N. Franz, Zhijian Qian, Linda B. Bloom, Matthew E. Merritt, Robert McKenna, Michael S. Kilberg
Publikováno v:
The Journal of biological chemistry. 298(9)
Asparagine synthetase (ASNS) catalyzes synthesis of asparagine (Asn) and Glu from Asp and Gln in an ATP-dependent reaction. Asparagine synthetase deficiency (ASNSD) results from biallelic mutations in the ASNS gene. Affected children exhibit congenit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b180d796527a9b3e0305269f1dc9b11
https://pubmed.ncbi.nlm.nih.gov/35985424
https://pubmed.ncbi.nlm.nih.gov/35985424
Autor:
Rohit Mahar, Mukundan Ragavan, Mario C. Chang, Savannah Hardiman, Nissin Moussatche, Adam Behar, Rolf Renne, Matthew E. Merritt
Publikováno v:
Scientific reports. 12(1)
Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has not been extensively studied. In this work, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cb2b815306fc6850e6b211376cf97a
https://pubmed.ncbi.nlm.nih.gov/35871072
https://pubmed.ncbi.nlm.nih.gov/35871072
Publikováno v:
Cancers
Simple Summary Cancer is often characterized by profound changes in metabolism, some of which are appropriate targets for therapeutic intervention. Many cancers overexpress the two-electron reductase NQO1, which can bioactivate the drug β-lapachone,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91cd6823fb560c6ce3fd94f16eabf732
https://pubmed.ncbi.nlm.nih.gov/34439319
https://pubmed.ncbi.nlm.nih.gov/34439319