Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mario Barberis"'
Autor:
María González-Esguevillas, David F. Fernández, Juan A. Rincón, Mario Barberis, Oscar de Frutos, Carlos Mateos, Susana García-Cerrada, Javier Agejas, David W. C. MacMillan
Publikováno v:
ACS Central Science, Vol 7, Iss 7, Pp 1126-1134 (2021)
Externí odkaz:
https://doaj.org/article/ddbad09150cd4a5b8d9d020dba099dd5
Autor:
Juan A. Rincón, Caroline Rouget-Virbel, Javier Agejas, Mario Barberis, Oscar de Frutos, Tomer M. Faraggi, Carlos Mateos, Susana García-Cerrada, David W. C. MacMillan
Publikováno v:
Org Process Res Dev
We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53349cf431fe7e5bee0f1b09f961709a
https://europepmc.org/articles/PMC9162430/
https://europepmc.org/articles/PMC9162430/
Autor:
Andrew D. Campbell, Rubén Haro, Thomas Andrew Brandt, Melodie Christensen, David B. Damon, Ke Wang, Carolina Alhambra, Paul C. Lobben, Jacob M. Janey, J. Eugenio de Diego, Ling Li, Iulia I. Strambeanu, Susana García-Cerrada, Javier Magano, Emma McInturff, Steven M. Mennen, Jack Twilton, David W. C. MacMillan, Fangfang Liu, Jesús Castañón, Matthew A. Zajac, Pablo Garcia-Losada, Sebastien Monfette, Mario Barberis, Alan H. Cherney, Jason M. Stevens, Barbara J. Sitter, Danielle M. Schultz, Ronald J. Post, Simon Berritt, C. Liana Allen, David C. Leitch
Publikováno v:
Organic Process Research & Development. 23:1213-1242
High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry, most notably allowing for rapid screening of compound libraries against therapeutic targets. The past decade ha...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d057d4265eaefcd550f067f2a336489
https://doi.org/10.1021/acs.oprd.9b00140
https://doi.org/10.1021/acs.oprd.9b00140
Autor:
Xiaheng Zhang, David W. C. MacMillan, Juan A. Rincón, Oscar de Frutos, Susana García-Cerrada, Carlos Mateos, Mario Barberis, Russell T. Smith, Javier Agejas
Publikováno v:
Journal of the American Chemical Society. 140:17433-17438
A strategy for the installation of small alkyl fragments onto pharmaceutically relevant aliphatic structures has been established via metallaphotoredox catalysis. Herein, we report that tris(trimethylsilyl)silanol can be employed as an effective halo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd65af6b8785e71cf9ea33219a959377
https://doi.org/10.1021/jacs.8b12025
https://doi.org/10.1021/jacs.8b12025
Autor:
Leonard L. Winneroski, Dustin J. Mergott, Amy C. DeBaillie, Yuan Shi, Brian Morgan Watson, Francisco Martínez-Olid, Carolina Alhambra Jimenez, Mario Barberis, Chauncey D. Jones, Pablo Garcia-Losada, Erik James Hembre
Publikováno v:
Organic Process Research & Development. 22:650-654
Here we report an optimized protocol for the asymmetric introduction of a fluorine atom into a quaternary center facilitated by d-proline, Selectfluor®, and trifluoroethanol. The synthesis proceeds over four steps starting from a chiral amino alcoho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605c2844dfb8d56a6a2a8fae33d2b3e2
https://doi.org/10.1021/acs.oprd.8b00069
https://doi.org/10.1021/acs.oprd.8b00069
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067
https://doi.org/10.1016/j.bmcl.2016.10.067
Autor:
Russell T, Smith, Xiaheng, Zhang, Juan A, Rincón, Javier, Agejas, Carlos, Mateos, Mario, Barberis, Susana, García-Cerrada, Oscar, de Frutos, David W C, MacMillan
Publikováno v:
Journal of the American Chemical Society. 140(50)
A strategy for the installation of small alkyl fragments onto pharmaceutically relevant aliphatic structures has been established via metallaphotoredox catalysis. Herein, we report that tris(trimethylsilyl)silanol can be employed as an effective halo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d519200bf9658e3f500bfddba012fef4
https://pubmed.ncbi.nlm.nih.gov/30516995
https://pubmed.ncbi.nlm.nih.gov/30516995
Autor:
David E. Timm, Leonard N. Boggs, Brian Michael Mathes, Yuan Shi, Mario Barberis, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Pablo Garcia-Losada, Jose Miguel Minguez, Leonard L. Winneroski, Jon A. Erickson, Richard A. Brier, Anthony R. Borders, Stephanie L. Stout, Porter Warren J, Zoran Rankovic, Jose Eduardo Lopez, Erik James Hembre, James E. Audia, Jorg Hendle, James P. Beck, Steven James Green, Brian Morgan Watson, Patrick C. May, Robert D. Boyer
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115194
Inhibition of BACE1 has become an important strategy in the quest for disease modifying agents to slow the progression of Alzheimer's disease. We previously reported the fragment-based discovery of LY2811376, the first BACE1 inhibitor reported to dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686975880a947f8f81325a11d876e66b
https://doi.org/10.1016/j.bmc.2019.115194
https://doi.org/10.1016/j.bmc.2019.115194
Autor:
Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein
Publikováno v:
Journal of medicinal chemistry. 59(24)
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967
https://pubmed.ncbi.nlm.nih.gov/28002967