Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Mario B. Marrero"'
Publikováno v:
Pharmaceutical Research. 28:413-416
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347815a4e8276b143701f1e1e767459b
https://doi.org/10.1007/s11095-010-0283-7
https://doi.org/10.1007/s11095-010-0283-7
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 23:83-88
1. Angiotensin II (AngII)-induced, activation of phospholipase C (PLC) and Ca2+-dependent Cl- channels is an important signal transduction pathway for the regulation of vascular smooth muscle cell (VSMC) and glomerular mesangial cell contraction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4421d98a8fdf8468671511bd3a2b41dc
https://doi.org/10.1111/j.1440-1681.1996.tb03067.x
https://doi.org/10.1111/j.1440-1681.1996.tb03067.x
Publikováno v:
Vascular Pharmacology. 53:160-168
Insulin resistance is an underlying mechanism of type 2 diabetes and its vascular complications. Recent evidence suggests that crosstalk between angiotensin II (Ang II) and the insulin signaling in vascular smooth muscle cell (VSMC) may contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b320d807a8810837a3827cd4f6c8ea
https://doi.org/10.1016/j.vph.2010.06.001
https://doi.org/10.1016/j.vph.2010.06.001
Autor:
David W. Stepp, Michel L. Tremblay, James D. Mintz, Eric J. Belin de Chantemèle, David J. Fulton, Mario B. Marrero, Kenjiro Muta
Publikováno v:
Circulation. 120:753-763
Background— Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin. Protein tyrosine phosphatase 1B (PTP1B), a major new pharmaceutical target in the treatment of obesity and type II diabetes mellitus, const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc004ea89422d4202456293beefdbd92
https://doi.org/10.1161/circulationaha.109.853077
https://doi.org/10.1161/circulationaha.109.853077
Autor:
Amy K.L. Banes-Berceli, Bela Patel, Mario B. Marrero, Pimonrat Ketsawatsomkron, Safia Ogbi, David M. Pollock
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H1291-H1299
The JAK/STAT pathway is activated in vitro by angiotensin II (ANG II) and endothelin-1 (ET-1), which are implicated in the development of diabetic complications. We hypothesized that ANG II and ET-1 activate the JAK/STAT pathway in vivo to participat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af32ff3070dc943c713a9bcc8d52019
https://doi.org/10.1152/ajpheart.00181.2007
https://doi.org/10.1152/ajpheart.00181.2007
Publikováno v:
American Journal of Physiology-Renal Physiology. 290:F762-F768
Excessive cellular growth is a major contributor to pathological changes associated with diabetic nephropathy. In particular, high glucose-induced growth of glomerular mesangial cells is a characteristic feature of diabetes-induced renal complication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d1036a7efb7daa41bb22e79cc5cdbb
https://doi.org/10.1152/ajprenal.00181.2005
https://doi.org/10.1152/ajprenal.00181.2005
Publikováno v:
Current Diabetes Reviews. 1:197-202
Excessive cellular proliferation is a major contributor to the pathological changes associated with the secondary complications of diabetes. In particular, hyperglycemia (HG)-induced growth of vascular smooth muscle cells (VSMC) and glomerular mesang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db31d7832ed9005a7c5993604a92bc7
https://doi.org/10.2174/1573399054022802
https://doi.org/10.2174/1573399054022802
Autor:
Ravichandran Ramasamy, Mario B. Marrero, Michiyo Kaneko, Sean Shaw, Yuying C. Hwang, Heather Redd
Publikováno v:
The FASEB Journal. 19:1-19
The aldose reductase pathway has been demonstrated to be a key component of myocardial ischemia reperfusion injury. Previously, we demonstrated that increased lactate/pyruvate ratio, a measure of cytosolic NADH/NAD+, is an important change that drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b588e834fa126f7c36d32821bab0c5
https://doi.org/10.1096/fj.04-2780fje
https://doi.org/10.1096/fj.04-2780fje
Autor:
Richard C. Venema, Mario B. Marrero, M. Brennan Harris, David J. Fulton, David W. Stepp, Bruce E. Kemp
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H2384-H2393
Previously, using an animal model of syndrome X, the obese Zucker rat (OZR), we documented impaired endothelium-dependent vasodilation. The aim of this study was to determine whether reduced expression or altered posttranslational regulation of endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610b774793fd58abe50f788dee7e631c
https://doi.org/10.1152/ajpheart.00280.2004
https://doi.org/10.1152/ajpheart.00280.2004
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 24:2009-2013
Although the importance of protein tyrosine phosphorylation by tyrosine kinases in mitogenic signaling is well-accepted, recent studies also suggest that tyrosine dephosphorylation by protein tyrosine phosphatases (PTPases) play an equally important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d0a3fdf84c6c9a27e9e0ebc8607ddb
https://doi.org/10.1161/01.atv.0000140059.04717.f3
https://doi.org/10.1161/01.atv.0000140059.04717.f3