Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mario Andres Blanco"'
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell
Externí odkaz:
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/515147b47c8045f7a83bb33af1989d17
Autor:
Yuhua Tian, Xin Wang, Zvi Cramer, Joshua Rhoades, Katrina N. Estep, Xianghui Ma, Stephanie Adams Tzivelekidis, Bryson W Katona, F Brad Johnson, Zhengquan Yu, Mario Andres Blanco, Christopher Lengner, Ning Li
Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally, with the majority of cases initiated by inactivation of the APC tumor suppressor. This results in the constitutive transcriptional activation of the canonical WNT signal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323fedb8ecb32d3a33efc381510be6f8
https://doi.org/10.1101/2022.07.26.501557
https://doi.org/10.1101/2022.07.26.501557
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a71feec96e8378f6c5d3d7d7162d3d
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
Autor:
Hemma Murali, Ajeya Nandi, Serge Y. Fuchs, Ratnesh Kumar Srivastava, Sabrina Kim, M. Raza Zaidi, Snahlata Singh, Mario Andres Blanco, Sushil Kumar, Rizwan Saffie, Gatha Thacker, Luca Busino, Mary Baldeon, Rumela Chakrabarti, Satrajit Sinha, John W. Tobias
Publikováno v:
Nat Cell Biol
Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that loss of the tumour suppressive transcription factor Elf5 in TNBC ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757521dabbdecdc7ed63bf4e14d709ad
https://doi.org/10.1038/s41556-020-0495-y
https://doi.org/10.1038/s41556-020-0495-y
Autor:
Mario Andres Blanco, Haitao Li
Publikováno v:
EBioMedicine, Vol 65, Iss, Pp 103237-(2021)
The Dnmt3a DNA methyltransferase is essential for mammalian development and is responsible for the generation of genomic methylation patterns, which lead to transcriptional silencing. Here, we show that Dnmt3a associates with RP58, a DNA-binding tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904e3f7e18010efcc91bf8d20ceac928
https://pubmed.ncbi.nlm.nih.gov/11350943
https://pubmed.ncbi.nlm.nih.gov/11350943
Autor:
Shawn M. Gillespie, Mariella G. Filbin, Mirhee Kim, Sanda Alexandrescu, Rhoda M. Alani, Muzhou Wu, Barry M. Zee, Bradley E. Bernstein, Jayanta Das, Jay H. Kalin, Dennis M. Bonal, Mario Andres Blanco, Yang Shi, Jamie N. Anastas, Mario L. Suvà, Philip A. Cole, Sarah E. Nocco, Stefanie Giera, Quang-Dé Nguyen, Todd R. Golub, Robyn Guo
Summary H3K27M mutations resulting in epigenetic dysfunction are frequently observed in diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer. We conduct a CRISPR screen revealing that knockout of KDM1A encoding lysine-specific deme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7985b7367f1f2b0f6ca319c3842d545
https://ora.ox.ac.uk/objects/uuid:3fae49db-2d10-4a57-bbd4-c0e4e76733e7
https://ora.ox.ac.uk/objects/uuid:3fae49db-2d10-4a57-bbd4-c0e4e76733e7
Autor:
Christian Gluck, Kevin Alicea-Torres, Rumela Chakrabarti, David W. Wilkes, Mario Andres Blanco, Anupma Nayak, Dmitry I. Gabrilovich, Nina Samuel, Satrajit Sinha, Sushil Kumar
Publikováno v:
Journal of Clinical Investigation. 128:5095-5109
Triple-negative breast cancer (TNBC) is particularly aggressive, with enhanced incidence of tumor relapse, resistance to chemotherapy, and metastases. As the mechanistic basis for this aggressive phenotype is unclear, treatment options are limited. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b133b82908e2cc669fcd286bf86d019
https://doi.org/10.1172/jci99673
https://doi.org/10.1172/jci99673
Autor:
Ukjin Kim, Rahul Debnath, Javier E. Maiz, Joshua Rico, Satrajit Sinha, Mario Andrés Blanco, Rumela Chakrabarti
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109366- (2024)
Summary: Triple-negative breast cancer (TNBC) contributes greatly to mortality of breast cancer, demanding new targetable options. We have shown that TNBC patients have high ΔNp63 expression in tumors. However, the function of ΔNp63 in established
Externí odkaz:
https://doaj.org/article/e9fd99b79e7240e78aa30f8687498c0c
Autor:
Luca Busino, Sushil Kumar, Mario Andres Blanco, Hemma Murali, Satrajit Sinha, Rizwan Saffie, John W. Tobias, M. Raza Zaidi, Rumela Chakrabarti, Serge Y. Fuchs, Ajeya Nandi, Gatha Thacker, Mary Baldeon, Ratnesh Kumar Srivastava, Sabrina Kim, Snahlata Singh
Publikováno v:
Nature Cell Biology. 23:1048-1048
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f8b9b47b0255a1fb4b91bb3e0ad2692
https://doi.org/10.1038/s41556-021-00733-7
https://doi.org/10.1038/s41556-021-00733-7