Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mario Öeren"'
Autor:
Lukas Ustrnul, Tatsiana Burankova, Mario Öeren, Kristina Juhhimenko, Jenni Ilmarinen, Kristjan Siilak, Kamini A. Mishra, Riina Aav
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Inherently chiral, barrel-shaped, macrocyclic hosts such as cyclohexanohemicucurbit[n]urils (cycHC[n]) bind zinc porphyrins and trifluoroacetic acid externally in halogenated solvents. In the current study, we tested a set of eighteen organic guests
Externí odkaz:
https://doaj.org/article/e9d2ad30c0fb4e84900e888457cc1d01
Autor:
Sergei Žari, Tiiu Kailas, Marina Kudrjashova, Mario Öeren, Ivar Järving, Toomas Tamm, Margus Lopp, Tõnis Kanger
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1452-1457 (2012)
The organocatalytic Michael addition of malonates to symmetric unsaturated 1,4-diketones catalyzed by thiourea and squaramide derivatives with Cinchona alkaloids afforded the formation of a new C–C bond in high yields (up to 98%) and enantiomeric p
Externí odkaz:
https://doaj.org/article/d9dce444c75c47af81065aa7936c6058
Publikováno v:
Journal of Chemical Information and Modeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a8a82149284dbe7d119ab6ca62b6cc
https://doi.org/10.1021/acs.jcim.3c00275
https://doi.org/10.1021/acs.jcim.3c00275
Publikováno v:
Journal of medicinal chemistry. 65(20)
Unexpected metabolism in modification and conjugation phases can lead to the failure of many late-stage drug candidates or even withdrawal of approved drugs. Thus, it is critical to predict the sites of metabolism (SoM) for enzymes, which interact wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3668ebfb240b7072df41341f05b71c7b
https://pubmed.ncbi.nlm.nih.gov/36239985
https://pubmed.ncbi.nlm.nih.gov/36239985
Publikováno v:
Journal of Computer-Aided Molecular Design. 35:541-555
We present a study based on density functional theory calculations to explore the rate limiting steps of product formation for oxidation by Flavin-containing Monooxygenase (FMO) and glucuronidation by the UDP-glucuronosyltransferase (UGT) family of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7c90b69d08a30386200462493a3992
https://doi.org/10.1007/s10822-020-00321-1
https://doi.org/10.1007/s10822-020-00321-1
Autor:
Davy Guan, Alexander Wade, Edwin G Tse, Alice Motion, Willem P. van Hoorn, Jonathan Cardoso-Silva, Adele M. Lehane, Giovanni Cincilla, Mario Öeren, Julia C. R. Lindblom, Mykola Galushka, Murray N. Robertson, Matthew H. Todd, James McCulloch, Slade Matthews, Mark G. Anderson, Benedict Irwin, Thomas M. Whitehead, Paul Willis, Laksh Aithani, Ho Leung Ng, Gareth Conduit, Vasileios A. Tatsis, Vito Spadavecchio, Raymond Lui, Kiaran Kirk, Irene Hallyburton
Publikováno v:
Journal of medicinal chemistry. 64(22)
The discovery of new antimalarial medicines with novel mechanisms of action is key to combating the problem of increasing resistance to our frontline treatments. The Open Source Malaria (OSM) consortium has been developing compounds ("Series 4") that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226bb29c6cfb2827cc0b24dac6a0807c
https://pubmed.ncbi.nlm.nih.gov/34748707
https://pubmed.ncbi.nlm.nih.gov/34748707
Autor:
Jenni Ilmarinen, Tatsiana Burankova, Kamini A. Mishra, Mario Öeren, Kristjan Siilak, Kristina Juhhimenko, Riina Aav, Lukas Ustrnul
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Inherently chiral, barrel-shaped, macrocyclic hosts such as cyclohexanohemicucurbit[n]urils (cycHC[n]) bind zinc porphyrins and trifluoroacetic acid externally in halogenated solvents. In the current study, we tested a set of eighteen organic guests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5db7e74bf09269861a5112c545df48e
https://doi.org/10.3389/fchem.2021.701028
https://doi.org/10.3389/fchem.2021.701028
Publikováno v:
Chemical Communication
This research with title "Dynamic chiral cyclohexanohemicucurbit[12]uril" is dedicated to the memory of late Professor Hans J. Reich.Abstract:NMR and DFT studies of chiral cyclohexanohemicucurbit[12]uril indicate that the macrocycle adopts a concave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bc6331a6854a96cfaacea369c19797
https://pubmed.ncbi.nlm.nih.gov/33155596
https://pubmed.ncbi.nlm.nih.gov/33155596
Autor:
Hans J. Reich, Jasper Adamson, Elina Kalenius, Riina Aav, Filip Topić, Aivar Lookene, Mart Reimund, Kari Rissanen, Elena Prigorchenko, Mario Öeren, Sandra Kaabel, Anniina Kiesilä
Publikováno v:
Chemical Science. 8:2184-2190
A novel eight-membered macrocycle of the hemicucurbit[n]uril family, chiral (all-R)-cyclohexanohemicucurbit[8]uril (cycHC[8]) binds anions in a purely protic solvent with remarkable selectivity. The cycHC[8] portals open and close to fully encapsulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7fd8dfa58215bf0f616074ccab4a31
https://doi.org/10.1039/c6sc05058a
https://doi.org/10.1039/c6sc05058a
Autor:
Toomas Tamm, Ivar Järving, Kari Rissanen, Maria Fomitšenko, Riina Aav, Sandra Kaabel, Filip Topić, Mario Öeren, Indrek Reile, Elena Prigorchenko
Publikováno v:
Chemical Communications. 51:10921-10924
Enantiomerically pure cyclohexylhemicucurbit[8]uril (cycHC[8]), possessing a barrel-shaped cavity, has been prepared in high yield on a gram scale from either (R,R,N,N')-cyclohex-1,2-diylurea and formaldehyde or cycHC[6]. In either case, a dynamic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a551c984643828790af1da98906cd5fc
https://doi.org/10.1039/c5cc04101e
https://doi.org/10.1039/c5cc04101e