Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Mario, van der Stelt"'
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Xiaoting Li, Hao Chang, Jara Bouma, Laura V. de Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J. B. H. N. van den Berg, Antonius P. A. Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H. Heitman, Tian Hua
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. Here, authors report the discovery of LEI-102, a CB2R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigat
Externí odkaz:
https://doaj.org/article/4a0327fb90ed454caed0f1b796b69018
Autor:
Natascha Berger, Tom van der Wel, Birgit Hirschmugl, Thomas Baernthaler, Juergen Gindlhuber, Nermeen Fawzy, Thomas Eichmann, Ruth Birner-Gruenberger, Robert Zimmermann, Mario van der Stelt, Christian Wadsack
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionLipids and fatty acids are key components in metabolic processes of the human placenta, thereby contributing to the development of the fetus. Placental dyslipidemia and aberrant activity of lipases have been linked to diverse pregnancy as
Externí odkaz:
https://doaj.org/article/554df234a0eb4e46ba913fb591099917
PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells
Autor:
Susanne Prokop, Péter Ábrányi-Balogh, Benjámin Barti, Márton Vámosi, Miklós Zöldi, László Barna, Gabriella M. Urbán, András Dávid Tóth, Barna Dudok, Attila Egyed, Hui Deng, Gian Marco Leggio, László Hunyady, Mario van der Stelt, György M. Keserű, István Katona
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The authors introduce PharmacoSTORM single-molecule imaging that uses fluorescent ligands and immunolabeling for cellular and subcellular nanoscale molecular pharmacology. They demonstrate its capabilities by visualizing cariprazine binding to D3 dop
Externí odkaz:
https://doaj.org/article/7fdcba0c8de84fc9bca36e38db68d9ba
Autor:
Tom van der Wel, Riet Hilhorst, Hans den Dulk, Tim van den Hooven, Nienke M. Prins, Joost A. P. M. Wijnakker, Bogdan I. Florea, Eelke B. Lenselink, Gerard J. P. van Westen, Rob Ruijtenbeek, Herman S. Overkleeft, Allard Kaptein, Tjeerd Barf, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Chemical tools to monitor drug-target engagement of endogenous enzymes are essential for preclinical target validation. Here, the authors present a chemical genetics strategy to study target engagement of endogenous kinases, achieving specific labeli
Externí odkaz:
https://doaj.org/article/749ac4b664044b4d9100599885c8e063
Autor:
Sebastiaan T. A. Koenders, Lukas S. Wijaya, Martje N. Erkelens, Alexander T. Bakker, Vera E. van der Noord, Eva J. van Rooden, Lindsey Burggraaff, Pasquale C. Putter, Else Botter, Kim Wals, Hans van den Elst, Hans den Dulk, Bogdan I. Florea, Bob van de Water, Gerard J. P. van Westen, Reina E. Mebius, Herman S. Overkleeft, Sylvia E. Le Dévédec, Mario van der Stelt
Publikováno v:
ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
Externí odkaz:
https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017
Autor:
Amelie V. Bos, Martje N. Erkelens, Sebastiaan T.A. Koenders, Mario van der Stelt, Marjolein van Egmond, Reina E. Mebius
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The vitamin A derivative, retinoid acid (RA) is key player in guiding adaptive mucosal immune responses. However, data on the uptake and metabolism of vitamin A within human immune cells has remained largely elusive because retinoids are small, lipop
Externí odkaz:
https://doaj.org/article/9e24e345752c423bb1967e38d1e39e6a
Autor:
Lourdes Ortiz-Alvarez, Huiwen Xu, Xinyu Di, Isabelle Kohler, Francisco J. Osuna-Prieto, Francisco M. Acosta, Ramiro Vilchez-Vargas, Alexander Link, Julio Plaza-Díaz, Mario van der Stelt, Thomas Hankemeier, Mercedes Clemente-Postigo, Francisco J. Tinahones, Angel Gil, Patrick C. N. Rensen, Jonatan R. Ruiz, Borja Martinez-Tellez
Publikováno v:
Nutrients, Vol 14, Iss 10, p 2143 (2022)
Objective: To investigate the association of plasma levels of endocannabinoids with fecal microbiota. Methods: Plasma levels of endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as their eleven analogues, and arachidonic a
Externí odkaz:
https://doaj.org/article/3c1142e1b14f4ad99facfdbd45f42466
Autor:
Soraya Wilke Saliba, Hannah Jauch, Brahim Gargouri, Albrecht Keil, Thomas Hurrle, Nicole Volz, Florian Mohr, Mario van der Stelt, Stefan Bräse, Bernd L. Fiebich
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Neuroinflammation plays a vital role in Alzheimer’s disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system, and they play essential roles in the maintena
Externí odkaz:
https://doaj.org/article/b788349d4b7943ba9fa68ac1f83a7ec6
Autor:
Jara, Bouma, Marjolein, Soethoudt, Noortje, van Gils, Lizi, Xia, Mario, van der Stelt, Laura H, Heitman
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2576:189-199
Cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R) are G protein-coupled receptors (GPCRs) that activate a variety of pathways upon activation by (partial) agonists including the G protein pathway and the recruitment of β-arrestins. Dif