Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Mario, de Bono"'
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/986787789ebd40f990998c9e53516692
Autor:
Lina Zhao, Lorenz A Fenk, Lars Nilsson, Niko Paresh Amin-Wetzel, Nelson Javier Ramirez-Suarez, Mario de Bono, Changchun Chen
Publikováno v:
PLoS Biology, Vol 20, Iss 6, p e3001684 (2022)
The ability to detect and respond to acute oxygen (O2) shortages is indispensable to aerobic life. The molecular mechanisms and circuits underlying this capacity are poorly understood. Here, we characterize the behavioral responses of feeding Caenorh
Externí odkaz:
https://doaj.org/article/8798e230f3cc4fc8b7ab44cf3cfcb9e3
Autor:
Sean M. Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including es
Externí odkaz:
https://doaj.org/article/377402b6f41e4c2d90a5764edd0f5adf
Autor:
Giulio Valperga, Mario de Bono
Publikováno v:
eLife, Vol 11 (2022)
Animals that lose one sensory modality often show augmented responses to other sensory inputs. The mechanisms underpinning this cross-modal plasticity are poorly understood. We probe such mechanisms by performing a forward genetic screen for mutants
Externí odkaz:
https://doaj.org/article/6d732e8ac94a44268c4a6959692079a6
Autor:
Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F. Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C. Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W. Wingett, Hermine Kienberger, Karin Kleigrewe, Mario de Bono, Michael J. O. Wakelam, Olivia Casanueva
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock fa
Externí odkaz:
https://doaj.org/article/a78b7a74d13c459bbb5c8c7072758ce4
Publikováno v:
eLife, Vol 10 (2021)
The ubiquitous Ca2+ sensor calmodulin (CaM) binds and regulates many proteins, including ion channels, CaM kinases, and calcineurin, according to Ca2+-CaM levels. What regulates neuronal CaM levels, is, however, unclear. CaM-binding transcription act
Externí odkaz:
https://doaj.org/article/f73d88295e4f483da51d84234708abfc
Autor:
Jesse Cohn, Vivek Dwivedi, Giulio Valperga, Nicole Zarate, Mario de Bono, H. Robert Horvitz, Jonathan T. Pierce
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3703-3714 (2019)
The BH3-only family of proteins is key for initiating apoptosis in a variety of contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode Caenorhabditis elegans has provided a powerful system for studying and i
Externí odkaz:
https://doaj.org/article/ed511ddb50544658843df7ea6bd548d8
Autor:
Tessa Sinnige, Prashanth Ciryam, Samuel Casford, Christopher M Dobson, Mario de Bono, Michele Vendruscolo
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217746 (2019)
Although the aggregation of the amyloid-β peptide (Aβ) into amyloid fibrils is a well-established hallmark of Alzheimer's disease, the complex mechanisms linking this process to neurodegeneration are still incompletely understood. The nematode worm
Externí odkaz:
https://doaj.org/article/e1dcb596c3114b9f92b8a5ac45aaf50c
Publikováno v:
PLoS Genetics, Vol 14, Iss 6, p e1007435 (2018)
Neurons develop elaborate morphologies that provide a model for understanding cellular architecture. By studying C. elegans sensory dendrites, we previously identified genes that act to promote the extension of ciliated sensory dendrites during embry
Externí odkaz:
https://doaj.org/article/82de2ba15e5d4cada11084eed9a44973
Publikováno v:
Bio-Protocol, Vol 7, Iss 15 (2017)
This protocol describes a method for purifying glycosylated FLAG-tagged secreted proteins with disulfide bonds from mammalian cells. The purified products can be used for various applications, such as ligand binding assays.
Externí odkaz:
https://doaj.org/article/b0042c463f11457aab7d864d2ee312ed