Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Mario, Plaas"'
Autor:
Katyayani Singh, Mohan Jayaram, Arpana Hanumantharaju, Tambet Tõnissoo, Toomas Jagomäe, Kaie Mikheim, Srirathi Muthuraman, Scott F. Gilbert, Mario Plaas, Michael K. E. Schäfer, Jürgen Innos, Kersti Lilleväli, Mari-Anne Philips, Eero Vasar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Deletions and malfunctions of the IgLON family of cell adhesion molecules are associated with anatomical, behavioral, and metabolic manifestations of neuropsychiatric disorders. We have previously shown that IgLON genes are expressed in sens
Externí odkaz:
https://doaj.org/article/d7ce1fd477ba4acf9a2adb3821533519
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Autor:
Toomas Jagomäe, Nayana Gaur, Kadri Seppa, Riin Reimets, Marko Pastak, Mihkel Plaas, Allen Kaasik, Eero Vasar, Mario Plaas
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
AimWolfram Syndrome (WS) is a rare condition caused by mutations in Wfs1, with a poor prognosis and no cure. Mono-agonists targeting the incretin glucagon-like-peptide 1 (GLP-1) have demonstrated disease-modifying potential in pre-clinical and clinic
Externí odkaz:
https://doaj.org/article/837495d36ff5427582528fa2621ac92c
Autor:
Kersti Tepp, Jekaterina Aid-Vanakova, Marju Puurand, Natalja Timohhina, Leenu Reinsalu, Karin Tein, Mario Plaas, Igor Shevchuk, Anton Terasmaa, Tuuli Kaambre
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101250- (2022)
The protein wolframin is localized in the membrane of the endoplasmic reticulum (ER), influencing Ca2+ metabolism and ER interaction with mitochondria, but the exact role of the protein remains unclear. Mutations in Wfs1 gene cause autosomal recessiv
Externí odkaz:
https://doaj.org/article/b5451538ba144239b5ac911bbf428285
Autor:
Kadri Seppa, Toomas Jagomäe, Kaia Grete Kukker, Riin Reimets, Marko Pastak, Eero Vasar, Anton Terasmaa, Mario Plaas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Wolfram syndrome (WS) is a monogenic progressive neurodegenerative disease and is characterized by various neurological symptoms, such as optic nerve atrophy, loss of vision, cognitive decline, memory impairment, and learning difficulties. G
Externí odkaz:
https://doaj.org/article/e93aa6c7d66f4066a7c2017128bcf2ce
Autor:
Kadri Kangro, Mihhail Kurašin, Kiira Gildemann, Eve Sankovski, Eva Žusinaite, Laura Sandra Lello, Raini Pert, Ants Kavak, Väino Poikalainen, Lembit Lepasalu, Marilin Kuusk, Robin Pau, Sander Piiskop, Siimu Rom, Ruth Oltjer, Kairi Tiirik, Karin Kogermann, Mario Plaas, Toomas Tiirats, Birgit Aasmäe, Mihkel Plaas, Karl Mumm, Dagni Krinka, Ene Talpsep, Meelis Kadaja, Joachim M. Gerhold, Anu Planken, Andres Tover, Andres Merits, Andres Männik, Mart Ustav
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to impose a serious burden on health systems globally. Despite worldwide vaccination, social distancing and wearing masks, the spread of the virus is ongoing. One of the mechanism
Externí odkaz:
https://doaj.org/article/ded5bb1380934dd8b51d32fab3b9098b
Autor:
Maria Kaare, Mohan Jayaram, Toomas Jagomäe, Katyayani Singh, Kalle Kilk, Kaie Mikheim, Marko Leevik, Este Leidmaa, Jane Varul, Helis Nõmm, Kristi Rähn, Tanel Visnapuu, Mario Plaas, Kersti Lilleväli, Michael K. E. Schäfer, Mari-Anne Philips, Eero Vasar
Publikováno v:
Brain Sciences, Vol 12, Iss 12, p 1696 (2022)
In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (NEGR1) gene has been consistently linked with both depression and obesity. Although the linkage between NEGR1 and depression is the strongest, evidence also sugge
Externí odkaz:
https://doaj.org/article/41ceb0cd48634c0583a9c5fa36e51515
Autor:
Toomas Jagomäe, Kadri Seppa, Riin Reimets, Marko Pastak, Mihkel Plaas, Miriam A. Hickey, Kaia Grete Kukker, Lieve Moons, Lies De Groef, Eero Vasar, Allen Kaasik, Anton Terasmaa, Mario Plaas
Publikováno v:
Cells, Vol 10, Iss 11, p 3193 (2021)
Wolfram syndrome (WS), also known as a DIDMOAD (diabetes insipidus, early-onset diabetes mellitus, optic nerve atrophy and deafness) is a rare autosomal disorder caused by mutations in the Wolframin1 (WFS1) gene. Previous studies have revealed that g
Externí odkaz:
https://doaj.org/article/baf6b0dceefa49f8af4e77d5cbd8b3b4
Autor:
Maria Kaare, Kaie Mikheim, Kersti Lilleväli, Kalle Kilk, Toomas Jagomäe, Este Leidmaa, Maria Piirsalu, Rando Porosk, Katyayani Singh, Riin Reimets, Egon Taalberg, Michael K. E. Schäfer, Mario Plaas, Eero Vasar, Mari-Anne Philips
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1148 (2021)
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis,
Externí odkaz:
https://doaj.org/article/3fa39a5f9bad4a3b8a594aac064199b7
Autor:
Michal Cagalinec, Alexandra Zahradníková, Dominika Kováčová, Ludovit Paulis, Simona Kureková, Matej Hot’ka, Jana Pavelková, Mario Plaas, Marta Novotová, Ivan Zahradník
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Wolframin (Wfs1) is a membrane protein of the sarco/endoplasmic reticulum. Wfs1 mutations are responsible for the Wolfram syndrome, characterized by diabetic and neurological symptoms. Although Wfs1 is expressed in cardiac muscle, its role in this ti
Externí odkaz:
https://doaj.org/article/45199483757148e68b928411f9acc7f1