Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Mario, Passalacqua"'
Autor:
Daniela Verzola, Noemi Rumeo, Stefano Alberti, Fabrizio Loiacono, Sebastiano La Maestra, Mario Passalacqua, Cristina Artini, Elisa Russo, Enrico Verrina, Andrea Angeletti, Simona Matarese, Nicoletta Mancianti, Paolo Cravedi, Micaela Gentile, Francesca Viazzi, Pasquale Esposito, Edoardo La Porta
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e39426- (2024)
Microplastics (MPs) accumulate in tissues, including kidney tissue, while Bisphenol A (BPA) is a plasticizer of particular concern. At present, the combined effects of MPs and BPA are unexplored in human renal cells. Therefore, we exposed a proximal
Externí odkaz:
https://doaj.org/article/574d6acb37604437a1010c65c2276f29
Autor:
Sonia Spinelli, Lucrezia Guida, Mario Passalacqua, Mirko Magnone, Bujar Caushi, Elena Zocchi, Laura Sturla
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 2071 (2024)
Rat H9c2 cardiomyocytes overexpressing the abscisic acid (ABA) hormone receptors LANCL1 and LANCL2 have an increased mitochondrial proton gradient, respiration, and vitality after hypoxia/reoxygenation. Our aim was to investigate the role of the ABA/
Externí odkaz:
https://doaj.org/article/14cc1bd3a110460d9fa599201526cf2e
Autor:
Caterina Ivaldo, Mario Passalacqua, Anna Lisa Furfaro, Cristina d’Abramo, Santiago Ruiz, Prodyot K. Chatterjee, Christine N. Metz, Mariapaola Nitti, Philippe Marambaud
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) i
Externí odkaz:
https://doaj.org/article/8169a08a0cf84a9b98f50732f4d0ad0e
Autor:
Naomi Scarano, Francesco Di Palma, Nicola Origlia, Francesca Musumeci, Silvia Schenone, Sonia Spinelli, Mario Passalacqua, Elena Zocchi, Laura Sturla, Elena Cichero, Andrea Cavalli
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2754 (2023)
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits glutathionylation activity and is involved in the neutralization of reactive electrop
Externí odkaz:
https://doaj.org/article/abc95c220691413f81e9bfd0dbc7cf75
Autor:
Sonia Spinelli, Lucrezia Guida, Mario Passalacqua, Mirko Magnone, Vanessa Cossu, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1692 (2023)
The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO generation. The overexpression of LANCL1/2 increases transcription, phosphorylation
Externí odkaz:
https://doaj.org/article/4dc2e87cc10b4478ab8cb3949999c275
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
Autor:
Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its
Externí odkaz:
https://doaj.org/article/b489a67fc20044dc9afd570c0e341aec
Autor:
Pamela Becherini, Debora Soncini, Silvia Ravera, Elisa Gelli, Claudia Martinuzzi, Giulia Giorgetti, Antonia Cagnetta, Fabio Guolo, Federico Ivaldi, Maurizio Miglino, Sara Aquino, Katia Todoerti, Antonino Neri, Andrea Benzi, Mario Passalacqua, Alessio Nencioni, Ida Perrotta, Maria Eugenia Gallo Cantafio, Nicola Amodio, Antonio De Flora, Santina Bruzzone, Roberto M. Lemoli, Michele Cea
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 494 (2023)
Cancer cells fuel growth and energy demands by increasing their NAD+ biosynthesis dependency, which therefore represents an exploitable vulnerability for anti-cancer strategies. CD38 is a NAD+-degrading enzyme that has become crucial for anti-MM ther
Externí odkaz:
https://doaj.org/article/0e796c050e73475a981a9b6091ebf662
Autor:
Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Identification of novel vulnerabilities in the context of therapeutic resistance is emerging as a key challenge for cancer treatment. Recent studies have detected pervasive aberrant splicing in cancer cells, supporting its targeting for novel therape
Externí odkaz:
https://doaj.org/article/309434a4c8104d54bfdbb57fcf74b015
Autor:
Sonia Spinelli, Lucrezia Guida, Tiziana Vigliarolo, Mario Passalacqua, Giulia Begani, Mirko Magnone, Laura Sturla, Andrea Benzi, Pietro Ameri, Edoardo Lazzarini, Claudia Bearzi, Roberto Rizzi, Elena Zocchi
Publikováno v:
Cells, Vol 11, Iss 18, p 2888 (2022)
Abscisic acid (ABA) regulates plant responses to stress, partly via NO. In mammals, ABA stimulates NO production by innate immune cells and keratinocytes, glucose uptake and mitochondrial respiration by skeletal myocytes and improves blood glucose ho
Externí odkaz:
https://doaj.org/article/39205a5ca85e461aaf0422197f1a9c37
Autor:
Anna Lisa Furfaro, Giulia Loi, Caterina Ivaldo, Mario Passalacqua, Gabriella Pietra, Giovanni Enrico Mann, Mariapaola Nitti
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1171 (2022)
Induction of heme oxygenase 1 (HO-1) favors immune-escape in BRAFV600 melanoma cells treated with Vemurafenib/PLX4032 under standard cell culture conditions. However, the oxygen tension under standard culture conditions (~18 kPa O2) is significantly
Externí odkaz:
https://doaj.org/article/1affae77ce5e44549d3f30919a187b1a