Coordination Chemistry of Organoruthenium Compounds with Benzoylthiourea Ligands and their Biological Properties

Autor: Muhammad Hanif, Muhammad Rauf, Muhammad Ashraf Shaheen, Kelvin K. H. Tong, Shahida Parveen, Mario Kubanik, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger

Publikováno v: Chemistry – An Asian Journal. 14:1262-1270

Benzoylthiourea derivatives feature several donor atoms capable of coordinating to metal centers. We report here a series of Ru(η6 -p-cymene) complexes employing benzoylthiourea derivatives as ligands. Such ligands often coordinate to metal centers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaab7ba220eab21c7467d0ef79370b2
https://doi.org/10.1002/asia.201801798

From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

Autor: Christian G. Hartinger, Hilke Burmeister, Ayesha Zafar, Ingo Ott, Stephen M. F. Jamieson, Daniel M Ayine-Tora, Luciano Oehninger, Tilo Söhnel, Maria V. Babak, Hannah U. Holtkamp, Mario Kubanik, Sanam Movassaghi, Nelson Y. S. Lam, Christian Gaiddon, Dianna Truong, Jóhannes Reynisson

Publikováno v: Inorganic Chemistry
Inorganic Chemistry, American Chemical Society, 2018, 57 (22), pp.14427-14434. ⟨10.1021/acs.inorgchem.8b02634⟩
Inorganic Chemistry, 2018, 57 (22), pp.14427-14434. ⟨10.1021/acs.inorgchem.8b02634⟩

International audience; The promise of the metal(arene) structure as an anticancer pharmacophore has prompted intensive exploration of this chemical space. While N-heterocyclic carbene (NHC) ligands are widely used in catalysis, they have only recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c64fcd958b568fd362de4c47bb92d2
https://doi.org/10.1021/acs.inorgchem.8b02634

Quinoline-para-quinones and metals: coordination-assisted formation of quinoline-ortho-quinones

Autor: Tilo Söhnel, Nelson Y. S. Lam, Christian G. Hartinger, Robert F. Anderson, Stephen M. F. Jamieson, Mario Kubanik, Hannah U. Holtkamp

Publikováno v: Chemical Communications. 54:992-995

The reaction of the para-quinone 6,7-dichloroquinoline-5,8-dione with various transition metal dimers led to the unexpected formation of quinoline-ortho-quinone metal complexes. Systematic variation of the reaction conditions helped identify the solv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79273acc1d2e4c543f046e6e021c64e9
https://doi.org/10.1039/c7cc09478g

Anticancer Ru(η6-p-cymene) complexes of 2-pyridinecarbothioamides: A structure–activity relationship study

Autor: Muhammad Hanif, Christian G. Hartinger, Amir Waseem, Sanam Movassaghi, Stephen M. F. Jamieson, Jahanzaib Arshad, Tilo Söhnel, Mario Kubanik

Publikováno v: Journal of Inorganic Biochemistry. 177:395-401

Ru(II) and Os(II) complexes of 2-pyridinecarbothioamide ligands were introduced as orally administrable anticancer agents (S.M. Meier, M. Hanif, Z. Adhireksan, V. Pichler, M. Novak, E. Jirkovsky, M.A. Jakupec, V.B. Arion, C.A. Davey, B.K. Keppler, C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070a36a586d6ee4df3e40ca68a12dcb1
https://doi.org/10.1016/j.jinorgbio.2017.08.034

Anti-Inflammatory Oxicams as Multi-donor Ligand Systems: pH- and Solvent-Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os

Autor: Stephen M. F. Jamieson, Mario Kubanik, Tilo Söhnel, Farhana Aman, Muhammad Hanif, Waseeq Ahmad Siddiqui, Christian G. Hartinger, Adnan Ashraf

Publikováno v: Chemistry - A European Journal. 23:4893-4902

The nitrogen- and sulfur-containing 1,2-benzothiazines meloxicam and piroxicam are widely used as nonsteroidal anti-inflammatory drugs. Intrigued by the presence of multiple donor atoms and therefore potentially rich coordination chemistry, we prepar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00f5ae5a80ee83fd52ceed4e06c9f37
https://doi.org/10.1002/chem.201700263