Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mario, Brosch"'
Autor:
Agnieska Brazovskaja, Tomás Gomes, Rene Holtackers, Philipp Wahle, Christiane Körner, Zhisong He, Theresa Schaffer, Julian Connor Eckel, René Hänsel, Malgorzata Santel, Makiko Seimiya, Timm Denecke, Michael Dannemann, Mario Brosch, Jochen Hampe, Daniel Seehofer, Georg Damm, J. Gray Camp, Barbara Treutlein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The liver has the remarkable capacity to regenerate. In the clinic, regeneration is induced by portal vein embolization, which redirects portal blood flow, resulting in liver hypertrophy in locations with increased blood supply, and atrophy
Externí odkaz:
https://doaj.org/article/2c51efcb6b67470b973d830653ff843e
Autor:
Wiebke Breternitz, Friedrich Sandkühler, Frauke Grohmann, Jochen Hampe, Mario Brosch, Alexander Herrmann, Clemens Schafmayer, Christian Meinhardt, Stefan Schreiber, Alexander Arlt, Claudia Geismann
Publikováno v:
Cells, Vol 11, Iss 21, p 3504 (2022)
Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD). By comparing methylati
Externí odkaz:
https://doaj.org/article/933daf0b06b54792a193896036ad38eb
Autor:
Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schuhmann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Züllig, Jürgen Hartler, Harald C. Köfeler, Christoph Röcken, Ünal Coskun, Edda Klipp, Witigo von Schoenfels, Justus Gross, Clemens Schafmayer, Jochen Hampe, Josch Konstantin Pauling, Andrej Shevchenko
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100104- (2021)
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood. Using high-resolution shotgun mass spectrometry, we quantified the mol
Externí odkaz:
https://doaj.org/article/baf15b6381f843daa555ad1b8cabc9ef
Autor:
Mario Brosch, Kathrin Kattler, Alexander Herrmann, Witigo von Schönfels, Karl Nordström, Daniel Seehofer, Georg Damm, Thomas Becker, Sebastian Zeissig, Sophie Nehring, Fabian Reichel, Vincent Moser, Raghavan Veera Thangapandi, Felix Stickel, Gustavo Baretton, Christoph Röcken, Michael Muders, Madlen Matz-Soja, Michael Krawczak, Gilles Gasparoni, Hella Hartmann, Andreas Dahl, Clemens Schafmayer, Jörn Walter, Jochen Hampe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Spatial mapping of genomic programs in tissue cells is an important step in the understanding of organ function and disease. Here, the authors provide a spatially resolved epigenomic and transcriptomic map of human liver and show porto-central gradie
Externí odkaz:
https://doaj.org/article/4dd3544c50324379ae45d9951935389b
Autor:
Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4553-4567.e7 (2019)
Summary: The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are larg
Externí odkaz:
https://doaj.org/article/e4c96ca3d041450cab536c7743532b75
Autor:
Felix Kordowski, Julia Kolarova, Clemens Schafmayer, Stephan Buch, Torsten Goldmann, Sebastian Marwitz, Christian Kugler, Swetlana Scheufele, Volker Gassling, Christopher G. Németh, Mario Brosch, Jochen Hampe, Ralph Lucius, Christian Röder, Holger Kalthoff, Reiner Siebert, Ole Ammerpohl, Karina Reiss
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background ADAMs (a disintegrin and metalloproteinase) have long been associated with tumor progression. Recent findings indicate that members of the closely related ADAMTS (ADAMs with thrombospondin motifs) family are also critically involv
Externí odkaz:
https://doaj.org/article/355ba03ade7149098ff32641d20c2307
Autor:
Markus Krauss, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert, Michael Block, Elke Schaeffeler, Gabriele Boehmer, Linus Goerlitz, Jan Hoecker, Joerg Lippert, Reinhold Kerb, Jochen Hampe, Lars Kuepfer, Matthias Schwab
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-11 (2017)
Systems pharmacology: predicting population pharmacokinetics in silico Physiologically based modeling together with Bayesian statistics allows the prediction of drug pharmacokinetics in specific patient populations. An interdisciplinary group of clin
Externí odkaz:
https://doaj.org/article/ec1cdb4109a643779b3939519f2d8816
Autor:
Geismann, Wiebke Breternitz, Friedrich Sandkühler, Frauke Grohmann, Jochen Hampe, Mario Brosch, Alexander Herrmann, Clemens Schafmayer, Christian Meinhardt, Stefan Schreiber, Alexander Arlt, Claudia
Publikováno v:
Cells; Volume 11; Issue 21; Pages: 3504
Obesity and obesity-associated diseases represent one of the key health challenges of our time. In this context, aberrant hepatic lipid accumulation is a central pathological aspect of non-alcoholic fatty liver disease (NAFLD). By comparing methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ee6519f1ffaf8e5a3d6f0c0f523a39d7
Autor:
Peter Juvan, Daniela Volke, Fritzi Ott, Christiane Körner, Ute Hofmann, Madlen Matz-Soja, Ralf Hoffmann, Thomas Berg, Luise Hochmuth, Kaja Blagotinšek Cokan, Mario Brosch, Damjana Rozman
Publikováno v:
Archives of Toxicology
The liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic, amino acid and lipid metabolism. Non-alcoholic fatty liver disease and hepatocellular carcinoma are among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40f970b0160ad1c0058cbe96d937f46
https://doi.org/10.1007/s00204-021-03118-9
https://doi.org/10.1007/s00204-021-03118-9
Autor:
Friedrich Stölzel, Mario Brosch, Steve Horvath, Michael Kramer, Christian Thiede, Malte von Bonin, Ole Ammerpohl, Moritz Middeke, Johannes Schetelig, Gerhard Ehninger, Jochen Hampe, Martin Bornhäuser
Publikováno v:
Haematologica, Vol 102, Iss 8 (2017)
Externí odkaz:
https://doaj.org/article/0b8902541456487aa95f5515b7c9e8eb