Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels

Autor: Marino Schuhmacher, Dirk Eick

Publikováno v: Transcription

The proto-oncogene c-myc encodes a basic helix-loop-helix leucine zipper transcription factor (c-Myc). c-Myc plays a crucial role in cell growth and proliferation. Here, we examined how expression of c-Myc target genes and cell proliferation depend o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7962bb7233fd7dbcc5bb2ca4ddd408cd
http://europepmc.org/articles/PMC3977919

The transcriptional program of a human B cell line in response to Myc

Autor: Dirk Eick, Helmut Burtscher, Ulrich H. Weidle, Axel Polack, Michael Hölzel, Franz Kohlhuber, Michael Jarsch, Georg W. Bornkamm, Carmen Kaiser, Gerhard Laux, Marino Schuhmacher

Publikováno v: Nucleic Acids Research. 29:397-406

The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of downstream genes. Here we report the identification of po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c668f1228a14569852100ea3e1ff8da9
https://doi.org/10.1093/nar/29.2.397

Control of cell growth by c-Myc in the absence of cell division

Autor: Alexander Pajic, Dirk Eick, Martin S. Staege, Marino Schuhmacher, Franz Kohlhuber, Georg W. Bornkamm, Axel Polack, Ulrich H. Weidle

Publikováno v: Current Biology. 9:1255-1258

The c-Myc protein (Myc) is a transcription factor, and deregulated expression of the c-myc gene (myc) is frequently found in tumours. In Burkitt's lymphoma (BL), myc is transcriptionally activated by chromosomal translocation. We have used a B-cell l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eadd2eddb34e9ea01ea86e2f5f1d329
https://doi.org/10.1016/s0960-9822(99)80507-7

C-Myc and Rel/NF-κB are the two master transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells

Autor: Nathalie Faumont, Reinhard Mailhammer, Andreas Rosenwald, Stéphanie Durand-Panteix, Marino Schuhmacher, Sebastian Grömminger, Gerhard Laux, Georg W. Bornkamm, Jean Feuillard, Martin Schlee, Louis M. Staudt, Michael Hölzel

Publikováno v: J. Virol. 83, 5014-5027 (2009)
Journal of Virology
Journal of Virology, American Society for Microbiology, 2009, 83 (10), pp.5014-27. ⟨10.1128/JVI.02264-08⟩

The Epstein-Barr virus (EBV) latency III program imposed by EBNA2 and LMP1 is directly responsible for immortalization of B cells in vitro and is thought to mediate most immunodeficiency-related posttransplant lymphoproliferative diseases in vivo. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912b1581be58ae4de7b73eeb1f33b866
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=1683

c-MYC impairs immunogenicity of human B cells

Autor: Martin, Schlee, Marino, Schuhmacher, Michael, Hölzel, Gerhard, Laux, Georg W, Bornkamm

Publikováno v: Advances in cancer research. 97

Deregulation of c-myc expression through chromosomal translocation is essential in the pathogenesis of Burkitt's lymphoma (BL). A characteristic feature of BL cells, compared to Epstein-Barr Virus (EBV)-immortalized B cells, is their lack of immunoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::244372da1039433fd7b860781db65ebf
https://pubmed.ncbi.nlm.nih.gov/17419945