Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics

Autor: Chandrawati, R, Olesen, MTJ, Marini, TCC, Bisra, G, Guex, AG, De Oliveira, MG, Zelikin, AN, Stevens, MM

Publikováno v: Chandrawati, R, Olesen, M T J, Marini, T C C, Bisra, G, Guex, A G, de Oliveira, M G, Zelikin, A N & Stevens, M M 2017, ' Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics ', Advanced Healthcare Materials, vol. 6, no. 17, 1700385 . https://doi.org/10.1002/adhm.201700385

Enzyme prodrug therapy (EPT) enables localized conversion of inert prodrugs to active drugs by enzymes. Performance of EPT necessitates that the enzyme remains active throughout the time frame of the envisioned therapeutic application. beta-glucuroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e2e4f7ba2e3f9f7df98b287c256eb81e
https://europepmc.org/articles/PMC5590711/

Green Electrospinning

Autor: Nesrin Horzum, Mustafa M. Demir, Rafael Muñoz-Espí, Daniel Crespy

The last two decades have seen electrospinning of nanofibers performed mainly from solutions of toxic organic solvents. The increase in demand for scaling up electrospinning in recent years therefore requires an environmentally friendly process free