Cardiomyocyte precursors generated by direct reprogramming and molecular beacon selection attenuate ventricular remodeling after experimental myocardial infarction.

Autor: Bachamanda Somesh D; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. dipthisomesh@gmail.com.; Berlin-Brandenburg School for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. dipthisomesh@gmail.com., Klose K; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. kristin.klose@charite.de.; Berlin-Brandenburg School for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. kristin.klose@charite.de., Maring JA; Institute of Active Polymers, Helmholtz-Zentrum Hereon, 14513, Teltow, Germany.; Berlin-Brandenburg Center for Regenerative Therapies, 13353, Berlin, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité - Medical Heart Center of Charité and German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany., Kunkel D; Cytometry Core Facility, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Jürchott K; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Institute for Medical Immunology, 13353, Berlin, Germany., Protze SI; University Health Network, McEwen Stem Cell Institute, Toronto, ON, M5G 1L7, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada., Klein O; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; BIH Imaging Mass Spectrometry Core Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Nebrich G; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; BIH Imaging Mass Spectrometry Core Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Becker M; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Berlin-Brandenburg School for Regenerative Therapies, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Krüger U; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Institute for Medical Immunology, 13353, Berlin, Germany., Nazari-Shafti TZ; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité - Medical Heart Center of Charité and German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; German Centre for Cardiovascular Research, Partner Site Berlin, 10785, Berlin, Germany., Falk V; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité - Medical Heart Center of Charité and German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.; German Centre for Cardiovascular Research, Partner Site Berlin, 10785, Berlin, Germany.; Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland., Kurtz A; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Gossen M; Institute of Active Polymers, Helmholtz-Zentrum Hereon, 14513, Teltow, Germany.; Berlin-Brandenburg Center for Regenerative Therapies, 13353, Berlin, Germany., Stamm C; BIH Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. stamm@dhzb.de.; Institute of Active Polymers, Helmholtz-Zentrum Hereon, 14513, Teltow, Germany. stamm@dhzb.de.; Berlin-Brandenburg Center for Regenerative Therapies, 13353, Berlin, Germany. stamm@dhzb.de.; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité - Medical Heart Center of Charité and German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. stamm@dhzb.de.; German Centre for Cardiovascular Research, Partner Site Berlin, 10785, Berlin, Germany. stamm@dhzb.de.

Publikováno v: Stem cell research & therapy [Stem Cell Res Ther] 2023 Oct 15; Vol. 14 (1), pp. 296. Date of Electronic Publication: 2023 Oct 15.

Cardiac Progenitor Cell-Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation.

Autor: Maring JA; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Lodder K; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Mol E; Laboratory of Experimental Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Verhage V; Laboratory of Experimental Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Wiesmeijer KC; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Dingenouts CKE; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Moerkamp AT; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Deddens JC; Laboratory of Experimental Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Vader P; Laboratory of Experimental Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.; Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands., Smits AM; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Sluijter JPG; Laboratory of Experimental Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.; UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands., Goumans MJ; Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands. m.j.goumans@lumc.nl.

Publikováno v: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2019 Feb; Vol. 12 (1), pp. 5-17. Date of Electronic Publication: 2018 Nov 19.

Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction.

Autor: Dingenouts CKE; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Bakker W; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Lodder K; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Wiesmeijer KC; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Moerkamp AT; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Maring JA; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Arthur HM; Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom., Smits AM; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., Goumans MJ; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.

Publikováno v: PloS one [PLoS One] 2017 Dec 18; Vol. 12 (12), pp. e0189805. Date of Electronic Publication: 2017 Dec 18 (Print Publication: 2017).

Myocardial Regeneration via Progenitor Cell-Derived Exosomes.

Autor: Maring JA; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Beez CM; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Falk V; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.; Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany., Seifert M; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Stamm C; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.; Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany.

Publikováno v: Stem cells international [Stem Cells Int] 2017; Vol. 2017, pp. 7849851. Date of Electronic Publication: 2017 Nov 23.

Interrogating TGF-β Function and Regulation in Endothelial Cells.

Autor: Maring JA; Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Centre for Biomedical Genetics, Leiden University Medical Center, Postzone S-1-P, Postbus 9600, 2300 RC, Leiden, The Netherlands. j.a.maring@lumc.nl., van Meeteren LA; Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Centre for Biomedical Genetics, Leiden University Medical Center, Postzone S-1-P, Postbus 9600, 2300 RC, Leiden, The Netherlands., Goumans MJ; Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Centre for Biomedical Genetics, Leiden University Medical Center, Postzone S-1-P, Postbus 9600, 2300 RC, Leiden, The Netherlands., Ten Dijke P; Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Centre for Biomedical Genetics, Leiden University Medical Center, Postzone S-1-P, Postbus 9600, 2300 RC, Leiden, The Netherlands.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2016; Vol. 1344, pp. 193-203.