Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder.

Autor: Leung CS; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.; Center for Translational Neuroscience, Carney Institute for Brain Science and Brown Institute for Translational Science (BITS), Brown University, Providence, RI 02912, USA., Rosenzweig SJ; Center for Computational Molecular Biology, Brown University, Providence, RI 02906, USA.; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02912, USA.; Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Academic Medical Center, Providence, RI 02903, USA., Yoon B; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA., Marinelli NA; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA., Hollingsworth EW; UCONN Health Comprehensive Multiple Sclerosis Center, Department of Neurology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.; Division of Multiple Sclerosis and Translational Neuroimmunology, Department of Neurology, University of Connecticut School of Medicine, Farmington, CT 06030, USA., Maguire AM; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.; Center for Translational Neuroscience, Carney Institute for Brain Science and Brown Institute for Translational Science (BITS), Brown University, Providence, RI 02912, USA., Cowen MH; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA., Schmidt M; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.; Center for Translational Neuroscience, Carney Institute for Brain Science and Brown Institute for Translational Science (BITS), Brown University, Providence, RI 02912, USA., Imitola J; UCONN Health Comprehensive Multiple Sclerosis Center, Department of Neurology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.; Division of Multiple Sclerosis and Translational Neuroimmunology, Department of Neurology, University of Connecticut School of Medicine, Farmington, CT 06030, USA., Gamsiz Uzun ED; Center for Computational Molecular Biology, Brown University, Providence, RI 02906, USA.; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02912, USA.; Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Academic Medical Center, Providence, RI 02903, USA., Lizarraga SB; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.; Center for Translational Neuroscience, Carney Institute for Brain Science and Brown Institute for Translational Science (BITS), Brown University, Providence, RI 02912, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2023 May 05; Vol. 32 (10), pp. 1634-1646.

A Simplified, Fully Defined Differentiation Scheme for Producing Blood-Brain Barrier Endothelial Cells from Human iPSCs.

Autor: Neal EH; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Marinelli NA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA., Shi Y; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., McClatchey PM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Balotin KM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Gullett DR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Hagerla KA; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Bowman AB; School of Health Sciences, Purdue University, West Lafayette, IN, USA., Ess KC; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Wikswo JP; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA., Lippmann ES; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address: ethan.s.lippmann@vanderbilt.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2019 Jun 11; Vol. 12 (6), pp. 1380-1388.

Plasma of COVID-19 Patients Does Not Alter Electrical Resistance of Human Endothelial Blood-Brain Barrier In Vitro.

Autor: Pociūtė, Agnė¹ (AUTHOR), Kriaučiūnaitė, Karolina¹ (AUTHOR), Kaušylė, Aida¹ (AUTHOR), Zablockienė, Birutė^2,3 (AUTHOR), Alčauskas, Tadas³ (AUTHOR), Jelinskaitė, Augustė² (AUTHOR), Rudėnaitė, Akvilė² (AUTHOR), Jančorienė, Ligita^2,3 (AUTHOR), Ročka, Saulius^3,4 (AUTHOR), Verkhratsky, Alexei^1,5,6,7 (AUTHOR) Alexej.Verkhratsky@manchester.ac.uk, Pivoriūnas, Augustas¹ (AUTHOR) augustas.pivoriunas@imcentras.lt

Publikováno v: Function. 2024, Vol. 5 Issue 2, p1-9. 9p.

Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease.

Autor: Haferkamp, Undine¹ (AUTHOR), Hartmann, Carla² (AUTHOR), Abid, Chaudhry Luqman² (AUTHOR), Brachner, Andreas³ (AUTHOR), Höchner, Alevtina⁴ (AUTHOR), Gerhartl, Anna³ (AUTHOR), Harwardt, Bernadette² (AUTHOR), Leckzik, Selin² (AUTHOR), Leu, Jennifer¹ (AUTHOR), Metzger, Marco^4,5 (AUTHOR), Nastainczyk-Wulf, Marina⁶ (AUTHOR), Neuhaus, Winfried^3,7 (AUTHOR), Oerter, Sabrina^4,5 (AUTHOR), Pless, Ole¹ (AUTHOR), Rujescu, Dan⁸ (AUTHOR), Jung, Matthias² (AUTHOR) matthias.jung@uk-halle.de, Appelt-Menzel, Antje^4,5 (AUTHOR) antje.appelt-menzel@uni-wuerzburg.de

Publikováno v: Fluids & Barriers of the CNS. 10/31/2023, Vol. 20 Issue 1, p1-20. 20p.

Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism.

Autor: Weber, Callie M.¹ (AUTHOR), Moiz, Bilal¹ (AUTHOR), Zic, Sophia M.¹ (AUTHOR), Alpízar Vargas, Viviana¹ (AUTHOR), Li, Andrew¹ (AUTHOR), Clyne, Alisa Morss¹ (AUTHOR) aclyne@umd.edu

Publikováno v: Fluids & Barriers of the CNS. 12/9/2022, Vol. 19 Issue 1, p1-15. 15p.