Výsledky vyhledávání - "Marinel M. Ammenheuser"

Single nucleotide polymorphisms of the DNA repair gene XPD/ERCC2 alter mRNA expression

Autor: Courtney E. Hill, Jeffrey K. Wickliffe, Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, Moreno Paolini, Kevin J. Wolfe

Publikováno v: Pharmacogenetics and Genomics. 17:897-905

Epidemiological studies documented associations between single nucleotide polymorphisms (SNPs) in the nucleotide excision repair gene XPD/ERCC2 and cancer risk. Little is known, however, about the underlying mechanisms for these associations. We expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490252d491820edbe591e07ba9da2592
https://doi.org/10.1097/fpc.0b013e3280115e63

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The L84F polymorphism in the O 6 -Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers

Autor: Carla J. Kinslow, Jeffrey K. Wickliffe, Marinel M. Ammenheuser, Sherif Z. Abdel-Rahman, Adele T. Guerin, Kevin J. Wolfe, Courtney E. Hill

Publikováno v: Pharmacogenetics and Genomics. 17:743-753

O-methylguanine-DNA-methyltransferase (MGMT) is a crucial DNA repair protein that removes DNA adducts formed by alkylating mutagens. Several coding single nucleotide polymorphisms (cSNPs) in the MGMT gene have been reported. Their biological signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d3668f046ef036bb5f0db380530341
https://doi.org/10.1097/fpc.0b013e3281111eb1

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Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene

Autor: Jeffrey K. Wickliffe, Jonathan B. Ward, Errol C. Friedberg, Lori A. Galbert, Lance M. Hallberg, Marinel M. Ammenheuser, Sherif Z. Abdel-Rahman, Jingwu Xie, Stacy M. Herring, R. Stephen Lloyd, Oscar E. Masters

Publikováno v: Chemico-Biological Interactions. 166:226-231

1,3-Butadiene (BD) is a well-documented mutagen and carcinogen in rodents and is currently classified as a probable carcinogen in humans. Studies investigating workers exposed to BD indicate that, in some plants, there may be an increased genetic ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d747e7787bb4a0e798a25c25fa7975ea
https://doi.org/10.1016/j.cbi.2006.04.017

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Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5′-Flanking Region of the Microsomal Epoxide Hydrolase Gene (EPHX1)

Autor: Judah I. Rosenblatt, Jeffrey K. Wickliffe, Jonathan B. Ward, Curtis J. Omiecinski, Marinel M. Ammenheuser, Sherif Z. Abdel-Rahman

Publikováno v: Toxicological Sciences. 85:624-631

The carcinogenic effects of 1,3-butadiene (BD), a mutagenic chemical widely used in the manufacture of synthetic rubber, are likely initiated through its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2901fe41c14362da9c72821e349c0104
https://doi.org/10.1093/toxsci/kfi115

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Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene

Autor: Sherif Z. Abdel-Rahman, Randa El-Zein, Zhen Yang, Jonathan B. Ward, Maria T. Morandi, Marinel M. Ammenheuser, Thomas H. Stock

Publikováno v: Environmental and Molecular Mutagenesis. 41:140-146

The carcinogenic effects of 1,3-butadiene (BD), a chemical widely used in the rubber industry, are thought to be due to its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92883dc9bb7a3a603aef143055e2fed9
https://doi.org/10.1002/em.10142

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Assessment of 1,3-butadiene exposure in polymer production workers using HPRT mutations in lymphocytes as a biomarker

Autor: Darlene A. Hastings-Smith, Jonathan B. Ward, Judah I. Rosenblatt, Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, William E. Bechtold

Publikováno v: Environmental Health Perspectives

1,3-Butadiene (BD), which is used to make styrene-butadiene rubber, is a potent carcinogen in mice and a probable carcinogen, associated with leukemia, in humans. We have previously used HPRT mutation as a biomarker to evaluate exposures to BD in a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ebf6dbe15dac702fd33fb619a89564
https://doi.org/10.1289/ehp.011091249

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Molecular analysis of hprt mutant lymphocytes from 1,3‐butadiene–exposed workers

Autor: Jonathan B. Ward, Thomas G. Wood, Marinel M. Ammenheuser, Hongbao Ma, Judah I. Rosenblatt

Publikováno v: Environmental and Molecular Mutagenesis. 36:59-71

1,3-Butadiene (BD) has been shown to be a potent animal carcinogen and a probable human carcinogen, yet the molecular mechanisms of BD genotoxicity and carcinogenicity still are not fully understood. Our hypothesis is that metabolites of BD induce sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b29d6c36c62b49de9fc05c723534e232
https://doi.org/10.1002/1098-2280(2000)36:1<59::aid-em9>3.0.co

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Frequencies ofhprt mutant lymphocytes in smokers, non-smokers, and former smokers

Autor: Jonathan B. Ward, Darlene A. Hastings, Marinel M. Ammenheuser, Elbert B. Whorton

Publikováno v: Environmental and Molecular Mutagenesis. 30:131-138

Previous work with the autoradiographic mutant lymphocyte assay has provided information about the time-course of development of hprt mutations and the persistence of detectable mutant cells in human subjects following therapeutic exposures to genoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43b6b0a9e08051f9849f67f4ead1399d
https://doi.org/10.1002/(sici)1098-2280(1997)30:2<131::aid-em5>3.0.co

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hprt mutant lymphocyte frequencies in workers at a 1,3-butadiene production plant

Autor: M. S. Legator, William E. Bechtold, Jonathan B. Ward, Elbert B. Whorton, Marinel M. Ammenheuser

Publikováno v: Environmental Health Perspectives

1,3-Butadiene is a major industrial chemical that has been shown to be a carcinogen at multiple sites in mice and rats at concentrations as low as 6.25 ppm. Occupational exposures have been reduced in response to these findings, but it may not be pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0904776510f6e3390f189593781c1970
https://doi.org/10.1289/ehp.94102s979

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Elevated frequencies of hprt mutant lymphocytes in cigarette-smoking mothers and their newborns

Autor: Jonathan B. Ward, Norma J. Stiglich, Abbey B. Berenson, Marinel M. Ammenheuser, Elbert B. Whorton

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 304:285-294

Maternal cigarette smoking during pregnancy has been associated with increased perinatal mortality and low birth weight. Several epidemiological studies have demonstrated an association between smoking during pregnancy and an elevated risk of hematop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7688f578279ef1fbdbe7e018c463ce4d
https://doi.org/10.1016/0027-5107(94)90221-6

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