Zobrazeno 1 - 10
of 527
pro vyhledávání: '"Marine alkaloids"'
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
Breast cancer is a major threat to women’s health worldwide. Although the 5-year survival rate is relatively high, treating recurrent and metastatic breast cancer remains challenging. Existing anticancer drugs are often accompanied by adverse react
Externí odkaz:
https://doaj.org/article/ce857d3df531429e96f299793d16310f
Autor:
Camilla Pecoraro, Francesca Terrana, Giovanna Panzeca, Barbara Parrino, Stella Cascioferro, Patrizia Diana, Elisa Giovannetti, Daniela Carbone
Publikováno v:
Molecules, Vol 28, Iss 18, p 6450 (2023)
The marine environment is an excellent source of molecules that have a wide structural diversity and a variety of biological activities. Many marine natural products (MNPs) have been established as leads for anticancer drug discovery. Most of these c
Externí odkaz:
https://doaj.org/article/35f42eb732474d3ca1a712d0e6773846
Publikováno v:
Metabolites, Vol 13, Iss 3, p 392 (2023)
The Condylactis-genus anemones were examined for their proteinaceous poisons over 50 years ago. On the other hand, the current research focuses on isolating and describing the non-proteinaceous secondary metabolites from the invasive Condylactis anem
Externí odkaz:
https://doaj.org/article/17667a6d9c1a4de8b278c3015f69e8df
Autor:
Diaa T. A. Youssef, Lamiaa A. Shaala
Publikováno v:
Marine Drugs, Vol 20, Iss 11, p 663 (2022)
Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 32,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a vital source for resear
Externí odkaz:
https://doaj.org/article/c2368658bfbf4b878c47e43fe66b91b4
Publikováno v:
Marine Drugs, Vol 20, Iss 4, p 262 (2022)
Marine alkaloids obtained from sponges possess a variety of biological activities and potential medicinal value. The pyrrole-derived lamellarin-like alkaloids, especially their permethyl derivatives, show low cytotoxicity and potent MDR reversing act
Externí odkaz:
https://doaj.org/article/98a7c34819a642c8bed46d69fe95787f
Autor:
Igor Kasheverov, Denis Kudryavtsev, Irina Shelukhina, Georgy Nikolaev, Yuri Utkin, Victor Tsetlin
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 189 (2022)
The purpose of our review is to briefly show what different compounds of marine origin, from low molecular weight ones to peptides and proteins, offer for understanding the structure and mechanism of action of nicotinic acetylcholine receptors (nAChR
Externí odkaz:
https://doaj.org/article/7bcbd9f3a9814d7ca09860ec493332e4
Akademický článek
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Autor:
Camilla Pecoraro, Barbara Parrino, Stella Cascioferro, Adrian Puerta, Amir Avan, Godefridus J. Peters, Patrizia Diana, Elisa Giovannetti, Daniela Carbone
Publikováno v:
Molecules, Vol 27, Iss 1, p 19 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacological targets for the treatment of sev
Externí odkaz:
https://doaj.org/article/060eab81821e4c8bbf38011113fb46d5
Autor:
Lamiaa A. Shaala, Diaa T. A. Youssef
Publikováno v:
Marine Drugs, Vol 19, Iss 12, p 691 (2021)
In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine sponges, we have investigated the sponge Hemimycale sp. The cytotoxic fraction of the organic extract of the sponge afforded three new compounds,
Externí odkaz:
https://doaj.org/article/de6a859f6c26424bbc3dd37c92f03986
Publikováno v:
Marine Drugs, Vol 19, Iss 12, p 658 (2021)
Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds. Marine indole alkaloids, from unique marine e
Externí odkaz:
https://doaj.org/article/cb82cbb048bf4ab091bc64b566201282