Exploring Cluster-Dependent Antibacterial Activities and Resistance Pathways of NOSO-502 and Colistin against Enterobacter cloacae Complex Species

Autor: Lucile Pantel, François Guérin, Marine Serri, François Gravey, Jessica Houard, Kelly Maurent, Marie Attwood, Alan Noel, Alasdair MacGowan, Emilie Racine, Vincent Cattoir, Maxime Gualtieri

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2022, pp.e0077622. ⟨10.1128/aac.00776-22⟩

International audience; The Enterobacter cloacae complex (ECC) is a group of diverse environmental and clinically relevant bacterial species associated with a variety of infections in humans. ECC have emerged as one of the leading causes of nosocomia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7504698bb64d306f520ff2e9f4802c91
https://doi.org/10.1128/aac.00776-22

Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in

Autor: Lucile, Pantel, Paulo, Juarez, Marine, Serri, Lilia, Boucinha, Emilie, Lessoud, Anne, Lanois, Alain, Givaudan, Emilie, Racine, Maxime, Gualtieri

Publikováno v: Antimicrob Agents Chemother

NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most of the colistin (CST)-resistant strains. Among a colle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61e7e1ad115eb202e4b0d034f9500a60
https://pubmed.ncbi.nlm.nih.gov/33685902

Total Synthesis and Structure–Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity

Autor: Marine Serri, Maxime Gualtieri, Philippe Villain-Guillot, Lucile Pantel, Matthieu Sarciaux, Cristelle Gerber, Renata Marcia de Figueiredo, Jean-Marc Campagne, Camille Midrier, Emilie Racine

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (17), pp.7814-7826. ⟨10.1021/acs.jmedchem.8b00790⟩

The spread of antibiotic-resistant pathogens is a growing concern, and new families of antibacterials are desperately needed. Odilorhabdins are a new class of antibacterial compounds that bind to the bacterial ribosome and kill bacteria through inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc58290138f7292ef971cda37cc09c87
https://doi.org/10.1021/acs.jmedchem.8b00790

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Autor: Alexander S. Mankin, Jean-Marc Campagne, Tanja Florin, Camille Midrier, Emilie Racine, Marine Serri, Maxime Gualtieri, Steve Forst, Malgorzata Dobosz-Bartoszek, André Aumelas, Sophie Gaudriault, Diarmaid Hughes, Matthieu Sarciaux, Philippe Villain-Guillot, Jessica Houard, Yury S. Polikanov, Jean-Michel Bolla, Carina Vingsbo Lundberg, Douglas L. Huseby, Christelle Cotteaux-Lautard, Lucile Pantel, Renata Marcia de Figueiredo, Anne Lanois, Alain Givaudan

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2018, 70 (1), pp.83-94. ⟨10.1016/j.molcel.2018.03.001⟩
Molecular Cell, 2018, 70 (1), pp.83-94. ⟨10.1016/j.molcel.2018.03.001⟩

International audience; Growing resistance of pathogenic bacteria and shortage of antibiotic discovery platforms challenge the use of antibiotics in the clinic. This threat calls for exploration of unconventional sources of antibiotics and identifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad5c19bf12626207dae8889278ce5f4
https://hal.archives-ouvertes.fr/hal-01761351