GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents

Autor: Marine Chazalon, Elena Paredes-Rodriguez, Stéphanie Morin, Audrey Martinez, Sofia Cristóvão-Ferreira, Sandra Vaz, Ana Sebastiao, Aude Panatier, Eric Boué-Grabot, Cristina Miguelez, Jérôme Baufreton

Publikováno v: Cell Reports, Vol 23, Iss 6, Pp 1678-1690 (2018)

Summary: The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson’s disease (PD), the rate and pattern of activity of GP neurons are profoundly altered

Externí odkaz: https://doaj.org/article/6b65f540e82340889cacf467ae4948ef

Proprioceptors-enriched neuronal cultures from induced pluripotent stem cells from Friedreich ataxia patients show altered transcriptomic and proteomic profiles, abnormal neurite extension, and impaired electrophysiological properties

Autor: Chiara Dionisi, Marine Chazalon, Myriam Rai, Céline Keime, Virginie Imbault, David Communi, Hélène Puccio, Serge N Schiffmann, Massimo Pandolfo

Publikováno v: Brain Communications. 5

Friedreich ataxia is an autosomal recessive multisystem disorder with prominent neurological manifestations and cardiac involvement. The disease is caused by large GAA expansions in the first intron of the FXN gene, encoding the mitochondrial protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::884e4836187b4a4fdbb4bf1e1ea7564a
https://doi.org/10.1093/braincomms/fcad007

Dysregulation of external globus pallidus‐subthalamic nucleus network dynamics in parkinsonian mice during cortical slow‐wave activity and activation

Autor: Mark D. Bevan, Jérôme Baufreton, Ryan F. Kovaleski, David L. Wokosin, Joshua W. Callahan, Marine Chazalon

Publikováno v: The Journal of Physiology
The Journal of Physiology, Wiley, 2020, 598 (10), pp.1897-1927. ⟨10.1113/JP279232⟩
J Physiol

Key points Reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) neurons form a key network within the basal ganglia. In Parkinson's disease and its models, abnormal rates and patterns of GPe-STN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d76a8f5ccc1dec66c178e96d3389dc5
https://hal.archives-ouvertes.fr/hal-02988867

Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in Parkinsonian mice

Autor: Jérôme Baufreton, Ryan F. Kovaleski, Marine Chazalon, Joshua W. Callahan, Mark D. Bevan

Reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) neurons form a key, centrally-positioned network within the basal ganglia, a group of subcortical brain nuclei critical for voluntary movement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5528922992dcc038fb2a36e5aa5b3ab

The GABAergic Gudden's dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse

Autor: Véronique Fabre, Patricia Bonnavion, Joëlle Adrien, Marine Chazalon, Alban de Kerchove d'Exaerde, Jean-François Bernard, Iman Sahly, Sylvie Dumas, M. Hamon, François Tronche

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2018, 138, pp.315-330. ⟨10.1016/j.neuropharm.2018.06.014⟩
Neuropharmacology, 2018, 138, pp.315-330. ⟨10.1016/j.neuropharm.2018.06.014⟩
Neuropharmacology, 138

Serotonin (5-HT) neurons are involved in wake promotion and exert a strong inhibitory influence on rapid eye movement (REM) sleep. Such effects have been ascribed, at least in part to the action of 5-HT at post-synaptic 5-HT1A receptors (5-HT1AR) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445b5720eb70652c3771e95f823d07c7
https://hal.archives-ouvertes.fr/hal-02333927/document