Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2

Autor: Manon Venet, Margarida Sa Ribeiro, Elodie Décembre, Alicia Bellomo, Garima Joshi, Célia Nuovo, Marine Villard, David Cluet, Magali Perret, Rémi Pescamona, Helena Paidassi, Thierry Walzer, Omran Allatif, Alexandre Belot, Sophie Trouillet-Assant, Emiliano P. Ricci, Marlène Dreux

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Plasmacytoid DC (pDC) have been shown to secrete type I IFN and to be involved in controlling replication and spread of some viruses. Here the authors show that in severe SARS-CoV-2 infection pDC function is impaired leading to reduced type I IFN pro

Externí odkaz: https://doaj.org/article/04fff4c178eb439c8dc6ad978ab2f441

Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Autor: Jérôme Hadjadj, Carla Noemi Castro, Maud Tusseau, Marie-Claude Stolzenberg, Fabienne Mazerolles, Nathalie Aladjidi, Martin Armstrong, Houman Ashrafian, Ioana Cutcutache, Georg Ebetsberger-Dachs, Katherine S. Elliott, Isabelle Durieu, Nicole Fabien, Mathieu Fusaro, Maximilian Heeg, Yohan Schmitt, Marc Bras, Julian C. Knight, Jean-Christophe Lega, Gaetan Lesca, Anne-Laure Mathieu, Marion Moreews, Baptiste Moreira, Audrey Nosbaum, Matthew Page, Cécile Picard, T. Ronan Leahy, Isabelle Rouvet, Ethel Ryan, Damien Sanlaville, Klaus Schwarz, Andrew Skelton, Jean-Francois Viallard, Sebastien Viel, Marine Villard, Isabelle Callebaut, Capucine Picard, Thierry Walzer, Stephan Ehl, Alain Fischer, Bénédicte Neven, Alexandre Belot, Frédéric Rieux-Laucat

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

SOCS1 is a potent suppressor of JAK-STAT signalling responses to IFNγ and γ-chain cytokines and thereby limits inflammation. Here the authors identify and characterize heterozygous SOCS1 mutations in 10 patients from 5 unrelated families with autoi

Externí odkaz: https://doaj.org/article/e099b2415a024179917630ee4d4f2ec2

Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

Autor: Marie Marotel, Marine Villard, Annabelle Drouillard, Issam Tout, Laurie Besson, Omran Allatif, Marine Pujol, Yamila Rocca, Michelle Ainouze, Guillaume Roblot, Sébastien Viel, Melissa Gomez, Veronique Loustaud, Sophie Alain, David Durantel, Thierry Walzer, Uzma Hasan, Antoine Marçais

Publikováno v: eLife, Vol 10 (2021)

Antiviral effectors such as natural killer (NK) cells have impaired functions in chronic hepatitis B (CHB) patients. The molecular mechanism responsible for this dysfunction remains poorly characterised. We show that decreased cytokine production cap

Externí odkaz: https://doaj.org/article/dbd000334d1a4ec4ae8522d37c9e9df7

Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination

Autor: Vincent Legros, Thierry Walzer, Jacqueline Marvel, Jean-Baptiste Fassier, Loïc Peyrot, Sophie Trouillet-Assant, Nicolas Guibert, Véronique Barateau, Thierry Defrance, Bruno Pozzetto, Thibault Andrieu, Bruno Lina, Sophia Djebali, Melyssa Yaugel-Novoa, Solène Denolly, Martine Valette, François-Loïc Cosset, Antonin Bal, Karen Brengel-Pesce, Amélie Massardier-Pilonchery, Omran Allatif, Thomas Bourlet, Bertrand Boson, Marine Villard, Stéphane Paul

Publikováno v: Nature
Nature, 2021, 600 (7890), pp.701-706. ⟨10.1038/s41586-021-04120-y⟩

Following severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine1,2, European health authorities have recommended that patients under the age of 55 who received one dose of ChAdOx1-S-nCoV-19 vaccine receive a second dose of Pfizer BNT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68944aa581f756a2679a4a19c16c6f7
https://doi.org/10.1038/s41586-021-04120-y

Cutting Edge: mTORC1 Inhibition in Metastatic Breast Cancer Patients Negatively Affects Peripheral NK Cell Maturation and Number

Autor: Olivier Tredan, Romaine Mayet, Magali Morelle, Benoit You, François Parant, Marine Villard, Isabelle Ray-Coquard, Thomas Bachelot, Sébastien Viel, David Pérol, Emily Charrier, Yamila Rocca, Gwenaële Garin, Antoine Marçais, Laurie Besson, Pierre Heudel, Thierry Walzer, Benoîte Méry

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2021, 206 (10), pp.2265-2270. ⟨10.4049/jimmunol.2001215⟩

NK cells are cytotoxic lymphocytes displaying strong antimetastatic activity. Mouse models and in vitro studies suggest a prominent role of the mechanistic target of rapamycin (mTOR) kinase in the control of NK cell homeostasis and antitumor function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e180998e3e82cff3446bcec6dba5a5
https://doi.org/10.4049/jimmunol.2001215