IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses

Autor: Gilles Dadaglio, Catherine Fayolle, Marine Oberkampf, Alexandre Tang, Francesc Rudilla, Isabelle Couillin, Eirik A. Torheim, Pierre Rosenbaum, Claude Leclerc

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

Antitumor immunity is mediated by Th1 CD4+ and CD8+ T lymphocytes, which induce tumor-specific cytolysis, whereas Th17 CD4+ T cells have been described to promote tumor growth. Here, we explored the influence of IL-17 on the ability of therapeutic va

Externí odkaz: https://doaj.org/article/5233de5bf6bf40c49d8d32de56bb46e2

Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses

Autor: Céline Cousin, Marine Oberkampf, Tristan Felix, Pierre Rosenbaum, Robert Weil, Sylvie Fabrega, Valeria Morante, Donatella Negri, Andrea Cara, Gilles Dadaglio, Claude Leclerc

Publikováno v: Cell Reports, Vol 26, Iss 5, Pp 1242-1257.e7 (2019)

Summary: Lentiviruses are among the most promising viral vectors for in vivo gene delivery. To overcome the risk of insertional mutagenesis, integrase-deficient lentiviral vectors (IDLVs) have been developed. We show here that strong and persistent s

Externí odkaz: https://doaj.org/article/066c2f9a277e49c2bf270907fe48d352

Suplementary Figures with legends from Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling

Autor: Claude Leclerc, Gilles Dadaglio, Camille Guillerey, Pierre Rosenbaum, Catherine Fayolle, Marine Oberkampf, Mariana Terra

Supplementary Figures S1 through S9. (1) Supplementary Figure S1: Phenotypical characterization of pDCs in the spleen of TC-1 and B16-OVA tumor-bearing mice. (2) Supplementary Figure S2. Purification of pDCs and gene family analysis. (3) Supplementar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfb54fb17db3f2c576f333566c186ef
https://doi.org/10.1158/0008-5472.22420470.v1

Lack of MHC class II molecules favors CD8+ T-cell infiltration into tumors associated with an increased control of tumor growth

Autor: Nada Chaoul, Alexandre Tang, Belinda Desrues, Marine Oberkampf, Catherine Fayolle, Daniel Ladant, Alexander Sainz-Perez, Claude Leclerc

Publikováno v: OncoImmunology, Vol 7, Iss 3 (2018)

Regulatory T-cells (Tregs) are crucial for the maintenance of immune tolerance and homeostasis as well as for preventing autoimmune diseases, but their impact on the survival of cancer patients remains controversial. In the TC-1 mouse model of human

Externí odkaz: https://doaj.org/article/372e0cff346f4805a68f729c359e39bc

Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile

Autor: Marc Monot, Audrey Hamiot, Benjamin A.R. Durand, Marine Oberkampf, Isabelle Martin-Verstraete, Bruno Dupuy, Yannick D. N. Tremblay

Publikováno v: ISME J
ISME Journal
ISME Journal, Nature Publishing Group, 2021, ⟨10.1038/s41396-021-01042-5⟩
ISME Journal, 2021, 15 (2), pp.3623-3635. ⟨10.1038/s41396-021-01042-5⟩

International audience; Clostridioides difficile infections are associated with gut microbiome dysbiosis and are the leading cause of hospital-acquired diarrhoea. The infectious process is strongly influenced by the microbiota and successful infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65292d140fea25fd0250f9f8ea60fbe8
https://europepmc.org/articles/PMC8630010/