Neutrophil depletion in the pre-implantation phase impairs pregnancy index, placenta and fetus development

Autor: Cristina Bichels Hebeda, Anna Carolina Savioli, Pablo Scharf, Marina de Paula-Silva, Cristiane Damas Gil, Sandra Helena Poliselli Farsky, Silvana Sandri

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Maternal neutrophils cells are players in gestational tolerance and fetus delivery. Nonetheless, their actions in each phase of the pregnancy are unknown. We here investigated the role of maternal neutrophil depletion before the blastocyst implantati

Externí odkaz: https://doaj.org/article/661d09eaa11f45ca905c2675da0dd902

Pioglitazone-Mediated Attenuation of Experimental Colitis Relies on Cleaving of Annexin A1 Released by Macrophages

Autor: Gustavo Henrique Oliveira da Rocha, Marina de Paula-Silva, Milena Fronza Broering, Pablo Rhasan dos Santos Scharf, Larissa Satiko Alcântara Sekimoto Matsuyama, Silvya Stuchi Maria-Engler, Sandra Helena Poliselli Farsky

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Ulcerative colitis and Crohn’s disease are chronic inflammatory bowel diseases (IBDs) which burden health systems worldwide; available pharmacological therapies are limited and cost-intensive. Use of peroxisome proliferator activated-receptor γ (P

Externí odkaz: https://doaj.org/article/b0b7383894b545aa80a7b09c26faf4b2

Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst

Autor: Cristina B. Hebeda, Silvana Sandri, Cláudia M. Benis, Marina de Paula-Silva, Rodrigo A. Loiola, Chris Reutelingsperger, Mauro Perretti, Sandra H. P. Farsky

Publikováno v: Cells, Vol 9, Iss 5, p 1188 (2020)

Embryo implantation into the uterine wall is a highly modulated, complex process. We previously demonstrated that Annexin A1 (AnxA1), which is a protein secreted by epithelial and inflammatory cells in the uterine microenvironment, controls embryo im

Externí odkaz: https://doaj.org/article/7aaf098a691d4cf4bb407e22d197d61d

Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis

Autor: Silvana Sandri, Cristina Bichels Hebeda, Milena Fronza Broering, Marina de Paula Silva, Luciana Facure Moredo, Milton José de Barros e Silva, André Sapata Molina, Clóvis Antônio Lopes Pinto, João Pedreira Duprat Neto, Chris P. Reutelingsperger, Cristiane Damas Gil, Sandra Helena Poliselli Farsky

Publikováno v: Cells, Vol 12, Iss 3, p 425 (2023)

Annexin A1 (AnxA1) is highly secreted by neutrophils and binds to formyl peptide receptors (FPRs) to trigger anti-inflammatory effects and efferocytosis. AnxA1 is also expressed in the tumor microenvironment, being mainly attributed to cancer cells.

Externí odkaz: https://doaj.org/article/8c0fc4ca602d42638af809e85a9cfa23

Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis

Autor: Chris P. M. Reutelingsperger, Jianmin Chen, Dianne Cooper, Mauro Perretti, Jose Garrido Mesa, Lucy V. Norling, Marina De Paula Silva, Sophie E. Burton

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 118(38):e2020385118. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America

Significance Patients with rheumatoid arthritis (RA) are susceptible to heart failure accompanied by diastolic dysfunction. It is unknown what causes diastolic dysfunction in RA, and current therapies do not reduce the risk of heart problems. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa88bd0f0fb57ebd84d7588ecd61f2d
https://doi.org/10.1073/pnas.2020385118