Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marina Y. Pushkareva"'
Publikováno v:
Cancer Immunology, Immunotherapy. 48:569-578
Association of the ether lipid, 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) with liposomes (ELL-12) reduces acute toxicity while maintaining or enhancing anticancer activity in experimental tumor models. ELL-12 has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a3cb22c6651dcf5fd080ff2e047bec
https://doi.org/10.1007/pl00006675
https://doi.org/10.1007/pl00006675
Publikováno v:
Cell Biology International. 23:817-828
1-O-Octadecyl-2-O-methyl-glycero-3-phosphocholine (ET-18-OCH(3)) selectively inhibits the growth of cancer cells. Here we show that in some cell types ET-18-OCH(3)and liposome-associated ET-18-OCH(3)inhibit cell division without concurrent inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2b97fe12fc57942a26abb1c91f41c
https://doi.org/10.1006/cbir.1999.0478
https://doi.org/10.1006/cbir.1999.0478
Autor:
Miriam J. Smyth, Rima Rachid, Ghassan Dbaibo, Marina Y. Pushkareva, N Alter, Lina M. Obeid, Yusuf A. Hannun
Publikováno v:
Journal of Clinical Investigation. 102:329-339
Both p53 and ceramide have been implicated in the regulation of growth suppression. p53 has been proposed as the "guardian of the genome" and ceramide has been suggested as a "tumor suppressor lipid. " Both molecules appear to regulate cell cycle arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0452a876fad6ab18bd903188f905e91
https://doi.org/10.1172/jci1180
https://doi.org/10.1172/jci1180
Publikováno v:
Lipids. 32:1045-1054
The growth inhibitory effects of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) and various liposome compositions of ET-18-OCH3 were compared in a standardized growth inhibition assay utilizing a diverse tumor cell line panel inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc350fe5f2c47950a3918caf01b2159
https://doi.org/10.1007/s11745-997-0135-8
https://doi.org/10.1007/s11745-997-0135-8
Publikováno v:
Immunology Today. 16:294-297
The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentation, apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293573810798531d2b3afafdd3445633
https://doi.org/10.1016/0167-5699(95)80184-7
https://doi.org/10.1016/0167-5699(95)80184-7
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
Autor:
James K. Schwarz, Lina M. Obeid, Jonathan M. Horowitz, Supriya Jayadev, Marina Y. Pushkareva, Yusuf A. Hannun, Ghassan Dbaibo
Publikováno v:
Scopus-Elsevier
Ceramide, a lipid mediator, has been most closely associated with antiproliferative activities. In this study, we examine the mechanism by which ceramide induces growth suppression and the role of the retinoblastoma gene product (Rb) in this process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e510d84481d59d7ad1f13a46a6122a
https://doi.org/10.1073/pnas.92.5.1347
https://doi.org/10.1073/pnas.92.5.1347
Autor:
Marina Y. Pushkareva, Yusuf A. Hannun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1221:54-60
Sphingosylphosphorylcholine (SPC), a putative product of sphingomyelin N-deacylation, has been shown to exert potent mitogenic activity (Desai, N.N. and Spiegel, S. (1991) Biochem. Biophys. Res. Commun. 181, 361-366). In order to explore potential me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f7b636ddc7c708b5bdd21eed9ddcbb
https://doi.org/10.1016/0167-4889(94)90215-1
https://doi.org/10.1016/0167-4889(94)90215-1
Autor:
Yusuf A. Hannun, H. M. Crane, Alicja Bielawska, Marina Y. Pushkareva, Richard Chao, Dennis C. Liotta, Bharat Lagu, Alfred H. Merrill
Publikováno v:
Biochemistry. 34(6)
Sphingosine has been shown to inhibit cell growth in many cell lines although the mechanism of this effect remains obscure. More recently, D-erythro-sphingosine has been shown to act as an early inducer of dephosphorylation of the retinoblastoma gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2357e5e582ede93190d1f05cf05e9d
https://pubmed.ncbi.nlm.nih.gov/7849048
https://pubmed.ncbi.nlm.nih.gov/7849048
Autor:
Marina Y. Pushkareva, Bin Liu, Lina M. Obeid, Yusuf A. Hannun, Fausta Nazaire, Joanna Y. Lee, Supriya Jayadev, Alicja Bielawska
Publikováno v:
The Journal of biological chemistry. 270(5)
The dependence of some cell types on serum factors for growth may represent a powerful, but poorly studied, model for antimitogenic pathways. In this study, we examine ceramide as a candidate intracellular mediator of serum factor dependence. In Molt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105efb117f9a75463770d9d99ceea28a
https://pubmed.ncbi.nlm.nih.gov/7836432
https://pubmed.ncbi.nlm.nih.gov/7836432