Mammographic density mediates the protective effect of early-life body size on breast cancer risk

Autor: Marina Vabistsevits, George Davey Smith, Tom G. Richardson, Rebecca C. Richmond, Weiva Sieh, Joseph H. Rothstein, Laurel A. Habel, Stacey E. Alexeeff, Bethan Lloyd-Lewis, Eleanor Sanderson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract The unexplained protective effect of childhood adiposity on breast cancer risk may be mediated via mammographic density (MD). Here, we investigate a complex relationship between adiposity in childhood and adulthood, puberty onset, MD phenoty

Externí odkaz: https://doaj.org/article/d78236665ac0478d9d7e3a296d3e9e09

Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response

Autor: Marta Lucchetta, Isabelle da Piedade, Mohamed Mounir, Marina Vabistsevits, Thilde Terkelsen, Elena Papaleo

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-20 (2019)

Abstract Background Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from

Externí odkaz: https://doaj.org/article/10e36e9d9d984b90baa9254f6db59729

Integrating Mendelian randomization and literature-mined evidence for breast cancer risk factors

Autor: Marina Vabistsevits, Tim Robinson, Ben Elsworth, Yi Liu, Tom Gaunt

An increasing challenge in population health research is efficiently utilising the wealth of data available from multiple sources to investigate the mechanisms of disease and identify potential intervention targets. The use of biomedical data integra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba773813b5a7db5c1198c0300879b284
https://doi.org/10.1101/2022.07.19.22277795

Cancer-related Mutations with Local or Long-range Effects on an Allosteric Loop of p53

Autor: Kristine Degn, Ludovica Beltrame, Freja Dahl Hede, Valentina Sora, Vincenzo Nicolaci, Marina Vabistsevits, Kjeld Schmiegelow, Karin Wadt, Matteo Tiberti, Matteo Lambrughi, Elena Papaleo

Publikováno v: Degn, K, Beltrame, L, Dahl Hede, F, Sora, V, Nicolaci, V, Vabistsevits, M, Schmiegelow, K, Wadt, K, Tiberti, M, Lambrughi, M & Papaleo, E 2022, ' Cancer-related Mutations with Local or Long-range Effects on an Allosteric Loop of p53 ', Journal of Molecular Biology, vol. 434, no. 17, 167663 . https://doi.org/10.1016/j.jmb.2022.167663

The tumor protein 53 (p53) is involved in transcription-dependent and independent processes. Several p53 variants related to cancer have been found to impact protein stability. Other variants, on the contrary, might have little impact on structural s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85785af289a57b862137faf86e7b4c2d
https://doi.org/10.1016/j.jmb.2022.167663

Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response

Autor: Isabelle da Piedade, Elena Papaleo, Marta Lucchetta, Thilde Terkelsen, Mohamed Mounir, Marina Vabistsevits

Publikováno v: Lucchetta, M, da Piedade, I, Mounir, M, Vabistsevits, M, Terkelsen, T & Papaleo, E 2019, ' Distinct signatures of lung cancer types : aberrant mucin O-glycosylation and compromised immune response ', BMC Cancer, vol. 19, 824 . https://doi.org/10.1186/s12885-019-5965-x
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-20 (2019)

Background Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from large-sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc30161c75e7ef65b9dea64e1b65f93b
https://doi.org/10.1186/s12885-019-5965-x