Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Marina V. Proskurnina"'
Autor:
Sergey A. Kuznetsov, Natalia A. Maximova, N. A. Zefirov, N. A. Lozinskaya, Birgit Wobith, Marina V. Proskurnina, Elena V. Kharitonashvili, Daniil R. Bazanov, Olga N. Zefirova, S. E. Sosonyuk
Publikováno v:
Mendeleev Communications. 30:7-9
To overcome the metabolic instability of anticancer agent 2-methoxyestradiol, two its dichloroacetylated prodrugs and three new control compounds have been synthesized and evaluated in different in vitro assays with cancer cells A549 and MCF-7. Both
Autor:
Alexander A. Spasov, A. V. Borisov, Lada V. Anikina, Marina V. Proskurnina, E.N. Bezsonova, Olga Yu. Zakharyascheva, N. A. Lozinskaya, Denis A. Babkov, Ekaterina V. Zaryanova, V. N. Perfilova, Michael D. Tsymlyakov, A.M. Efremov, Ivan N. Tyurenkov
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1804-1817
Glycogen synthase kinase 3β (GSK-3β) is a widely investigated molecular target for numerous diseases including Alzheimer’s disease, cancer, and diabetes mellitus. Inhibition of GSK-3β activity has become an attractive approach for treatment of d
Autor:
Viktor A. Tafeenko, Leonid A. Aslanov, Marina V. Proskurnina, Sergei E. Sosonyuk, Dmitrii A. Khlevin
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 8, Pp o2127-o2128 (2011)
The molecule of the title compound, C12H16O5, has crystallographically imposed mirror symmetry with the mirror plane passing through the endocyclic O atom and the mid-point of the double bond. In the crystal, molecules are linked by C—H...O hydroge
Externí odkaz:
https://doaj.org/article/23b8b795fd6d48bf9e93d9ee5518ada4
Autor:
Viktor A. Tafeenko, Leonid A. Aslanov, Marina V. Proskurnina, Sergei E. Sosonyuk, Dmitrii A. Khlevin
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 7, Pp o1580-o1580 (2009)
The title compound, 3C7H9ClO3·CHCl3, crystallizes with molecules of 3-exo-chloro-8-oxabicyclo[3.2.1]oct-6-ene-2,4-diol (A) and chloroform in a 3:1 ratio, in the space group R3m. Molecules of A straddle a crystallographic mirror plane, whereas the ch
Externí odkaz:
https://doaj.org/article/918aa0aec3884015b9399e074e61dbf7
Autor:
Tatiana D. Nekipelova, V. V. Temnov, Tatyana A. Podrugina, Vladimir A. Kuzmin, Nikolay S. Zefirov, Irina A. Doroshenko, Marina V. Proskurnina
Publikováno v:
Russian Chemical Bulletin. 65:2722-2728
A method for the synthesis of a series of water-soluble heptamethine indocyanine dyes containing a phosphonate group in the substituent bonded to the quaternary nitrogen atom of the indolenine moiety has been developed.
Synthesis and cytotoxicity of novel simplified eleutherobin analogues as potential antitumour agents
Autor:
Yulia A. Gracheva, Vladimir A. Palyulin, Marina N. Semenova, Dmitry I. Osolodkin, Victor V. Semenov, Marina V. Proskurnina, Anastasia V Tutushkina, Alexander A. Shtil, Nikolay S. Zefirov, Valeria A. Glazunova, S. E. Sosonyuk, Dmitry A. Khlevin, N. A. Lozinskaya, Anita Peshich
Publikováno v:
Organicbiomolecular chemistry. 17(10)
Mixed simplified structures containing the paclitaxel and eleutherobin pharmacophore moieties were analyzed using molecular docking techniques and synthesized based on adamantane and 8-oxabicyclo[3.2.1]octane scaffolds. The crucial role of substituen
Autor:
Elena D. Matveeva, Marina V. Proskurnina, Alexey A. Kostyukov, V. V. Temnov, V. A. Kuzmin, Nikolay S. Zefirov, Irina A. Doroshenko, Tatiana D. Nekipelova, Eugene V. Radchenko, G. V. Golovina, Tatyana A. Podrugina, Vladimir A. Palyulin
Publikováno v:
Doklady Chemistry. 470:264-267
New tricarbocyanine dyes with phosphonate groups (2, 3) were synthesized and their binding constants to bovine serum albumin (BSA) were determined. The binding constants of the synthesized tricarbocyanines and cardiogreen (1) (K b ~ 105 M–1) are si
Autor:
Nikolay S. Zefirov, M. Yu. Seliverstov, O. I. Afanas’ev, Marina V. Proskurnina, V. V. Temnov, S. E. Sosonyuk
Publikováno v:
Doklady Chemistry. 466:41-44
Open image in new window A method of preparative successive cycloaddition to synthetic equivalent of bis(dehydrobenzene) was found. Monoaddition products were isolated and characterized.
Autor:
S. R. Engel, S. E. Sosonyuk, Nikolay S. Zefirov, N. A. Lozinskaya, Yu. N. Firsova, Marina V. Proskurnina
Publikováno v:
Russian Chemical Bulletin. 64:76-82
The preparative procedure for the synthesis of N-(2,2,2-trichloro-1-hydroxyethyl)aldimines from the corresponding aldehyde, chloral, and ammonium acetate was developed. Preparative silylation and acylation of their hydroxy groups were acomplished for
Autor:
Nikolay S. Zefirov, O. A. Tsyplenkova, S. E. Sosonyuk, M. Yu. Seliverstov, O. I. Afanas´ev, Marina V. Proskurnina
Publikováno v:
Russian Chemical Bulletin. 64:1470-1472
Homocoupling of 4-bromo-1,2,3-triazoles upon treatment with stoichiometric amount of bis(pinacolato)diboron on a palladium catalyst gives 4,4´-bi-1,2,3-triazoles in up to 95% yields.