Oncogenic

Autor: Agata, Nyga, Jose J, Muñoz, Suze, Dercksen, Giulia, Fornabaio, Marina, Uroz, Xavier, Trepat, Buzz, Baum, Helen K, Matthews, Vito, Conte

Publikováno v: Science Advances

Description
Uniform RAS activation in an epithelium induces a 2D-to-3D transformation through induction of mechanical instability.
The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e113529018f7bb9e7e094c906ba00b86
https://pubmed.ncbi.nlm.nih.gov/34644109

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics

Autor: Vito Conte, Helen K. Matthews, Xavier Trepat, José J. Muñoz, Marina Uroz, Giulia Fornabaio, Agata Nyga, Suze Dercksen, Buzz Baum

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Science Advances, 7(42):eabg6467. American Association for the Advancement of Science (AAAS)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor development. Here, we ask how the uniform activation oncogene RAS affects the morphology and tissue mechanics in a normal epithelium. We found th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1cf28cb345e2bef3700bf0a6b41839
http://hdl.handle.net/2445/181240

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium

Autor: Juan F. Abenza, Xavier Trepat, Lorenzo Albertazzi, Isil Tekeli, Angel Raya, Marina Uroz, Silvia Pujals, Ariadna Marín-Llauradó, Pere Roca-Cusachs, Anna Garcia-Puig, Alberto Elosegui-Artola, Vito Conte

Publikováno v: Nature Materials
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Materials, 18(9), 1015-1023. Nature Publishing Group
Recercat. Dipósit de la Recerca de Catalunya
instname

Epithelial repair and regeneration are driven by collective cell migration and division. Both cellular functions involve tightly controlled mechanical events, but how physical forces regulate cell division in migrating epithelia is largely unknown. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778218ec67f2a544dcc9ecdb596ac4b9
http://hdl.handle.net/2445/139578

Active superelasticity in three-dimensional epithelia of controlled shape

Autor: Benoit Ladoux, Xavier Trepat, Elena Garreta, Manuel Gomez-Gonzalez, Aránzazu del Campo, Sohan Kale, Léo Valon, Laura Casares, Ernest Latorre, Marino Arroyo, Roshna V. Nair, Nuria Montserrat, Marina Uroz

Publikováno v: Nature
Nature, Nature Publishing Group, 2018, 563 (7730), pp.203-208. ⟨10.1038/s41586-018-0671-4⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Scipedia Open Access
Scipedia SL
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

Fundamental biological processes are carried out by curved epithelial sheets that enclose a pressurized lumen. How these sheets develop and withstand three-dimensional deformations has remained unclear. Here we combine measurements of epithelial tens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5fccf45dc6d19366e30e64b3e9494f
http://hdl.handle.net/2445/148077

Active Tensile Modulus of an Epithelial Monolayer

Autor: Carlos Pérez-González, Marina Uroz, Elsa Bazellières, Romaric Vincent, Xavier Serra-Picamal, Xavier Trepat

Publikováno v: ResearcherID
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Physical Review Letters
Physical Review Letters, American Physical Society, 2015, 115 (24), ⟨10.1103/PhysRevLett.115.248103⟩
Physical Review Letters, 2015, 115 (24), ⟨10.1103/PhysRevLett.115.248103⟩

A general trait of cell monolayers is their ability to exert contractile stresses on their surroundings. The scaling laws that link such contractile stresses with the size and geometry of constituent cells remain largely unknown. In this Letter, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1872ebd2c3cba3da09c331522cfaf8a5
https://doi.org/10.1103/physrevlett.115.248103