Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marina Statelova"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 53 (2023)
To date, food–drug interactions in the pediatric population remain understudied. The current food effect studies are mostly performed in adults and do not mimic the real-life situation in the pediatric population. Since the potential benefits of fo
Externí odkaz:
https://doaj.org/article/8c1714c7846f401e976b48f064323f90
Publikováno v:
Molecular Pharmaceutics.
Publikováno v:
The AAPS Journal. 24
Autor:
Laura J. Henze, Christos Reppas, Jennifer B. Dressman, Marina Statelova, Chara Litou, Christina Pentafragka, Patrick J O'Dwyer, Karl J. Box, Brendan T. Griffin, Maria Vertzoni
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:437-446
ObjectivesTo summarise key contributions of the Pharmaceutical Education and Research with Regulatory Links (PEARRL) project (2016–2020) to the optimisation of existing and the development of new biopharmaceutics tools for evaluating the in vivo pe
Autor:
Stefano Alcaro, Mirko Koziolek, Maria Vertzoni, Abdul Basit, Marina Statelova, Petr Pavek, Patrick Augustijns, Annalisa Maruca, Marc Maliepaard, Philipp Jedamzik, Diana van Riet-Nales, Bart Hens, Christos Reppas, Maura Corsetti, Kateřina Valentová, Christopher J.H. Porter, Natalie L. Trevaskis, Neil Parrott, Jari Rubbens, Luca Marciani, Christine M. Madla, Michael Grimm, Caroline L. Hoad, Dubravka Vitali Čepo
Publikováno v:
European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, 134, 31-59
European Journal of Pharmaceutical Sciences, 134, pp. 31-59
European Journal of Pharmaceutical Sciences, 134, 31-59
European Journal of Pharmaceutical Sciences, 134, pp. 31-59
The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of th
Publikováno v:
Statelova, M, Holm, R, Fotaki, N, Reppas, C & Vertzoni, M 2020, ' Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension ', AAPS Journal, vol. 22, no. 6, 146 . https://doi.org/10.1208/s12248-020-00522-4
The importance of physiologically based pharmacokinetic (PBPK) model refinement with data acquired in adults using a pediatric formulation under age-relevant dosing conditions in order to extrapolate drug exposure to infants was recently demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9850ff2377f30a6cf511bd851f28522d
https://purehost.bath.ac.uk/ws/files/214914147/Statelova_et_al._2020_accepted_manuscript.pdf
https://purehost.bath.ac.uk/ws/files/214914147/Statelova_et_al._2020_accepted_manuscript.pdf
Publikováno v:
Molecular Pharmaceutics
Hot melt extrusion of amorphous systems has become a pivotal technology to cope with challenges of poorly water-soluble drugs. Previous research showed that small molecular additives with targeted molecular interactions enabled introduction of a poly
Publikováno v:
Statelova, M, Holm, R, Fotaki, N, Reppas, C & Vertzoni, M 2020, ' Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions ', AAPS Journal, vol. 22, no. 6, 126 . https://doi.org/10.1208/s12248-020-00504-6
The AAPS Journal
The AAPS Journal
Extending licensed drug use to the pediatric population has become an essential part of the drug development process. Nonetheless, ethical concerns limit clinical testing in pediatric populations and data collected from oral bioavailability and food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6184760a622b7c43c6f4c8405a9a966
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2921501
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2921501
The importance of physiologically based pharmacokinetic (PBPK) model refinement for adults with data acquired in adults using a paediatric formulation under age-relevant dosing conditions in order to extrapolate drug exposure to infants was recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::b0aea4848cd6b8947938f57a7f1c7307
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2924233
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2924233
Autor:
Maria Vertzoni, Nikoletta Fotaki, Mira Symillides, Christos Reppas, Marina Statelova, Konstantinos Goumas, René Holm
Publikováno v:
Statelova, M, Goumas, K, Fotaki, N, Holm, R, Symillides, M, Reppas, C & Vertzoni, M 2020, ' On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants : an Exploratory Study Highlighting the Importance of Infant Food ', AAPS Journal, vol. 22, no. 1, 6 . https://doi.org/10.1208/s12248-019-0380-4
The AAPS Journal
The AAPS Journal
In the present investigation, it was explored whether food effect on drug absorption in adults is similar with the food effect after administration of an infant meal with the drug product to adults. After confirming lack of pharmaceutical and pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955e732292b5001cbbcd5b15acdefe33
https://purehost.bath.ac.uk/ws/files/202386757/Paediatric_food_effect_and_meals_adults_AAPS_J.pdf
https://purehost.bath.ac.uk/ws/files/202386757/Paediatric_food_effect_and_meals_adults_AAPS_J.pdf