Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Marina Schorpp-Kistner"'
Autor:
Karmveer Singh, Emanuela Camera, Linda Krug, Abhijit Basu, Rajeev Kumar Pandey, Saira Munir, Meinhard Wlaschek, Stefan Kochanek, Marina Schorpp-Kistner, Mauro Picardo, Peter Angel, Catherin Niemann, Pallab Maity, Karin Scharffetter-Kochanek
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberra
Externí odkaz:
https://doaj.org/article/22e44ec426b3467fbc580f37446b2625
Autor:
Peter Angel, Juliane Wutschka, Sila Appak-Baskoy, Bettina Kast, Marina Schorpp-Kistner, Hans-Peter Sinn, Melanie Sator-Schmitt, Jochen Hess
Publikováno v:
Clinical & Experimental Metastasis
The complex interactions between cells of the tumor microenvironment and cancer cells are considered a major determinant of cancer progression and metastasis. Yet, our understanding of the mechanisms of metastatic disease is not sufficient to success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a931612b0eec3455f1e72dc3c1612dc
https://doi.org/10.1007/s10585-021-10108-9
https://doi.org/10.1007/s10585-021-10108-9
Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging
Autor:
Wilhelm Bloch, Stefan Kochanek, Linda Krug, Peter Angel, Karmveer Singh, Meinhard Wlaschek, Anita Ignatius, Karin Scharffetter-Kochanek, A. Koroma, Pallab Maity, Marina Schorpp-Kistner, Hartmut Geiger, Adelheid Hainzl
Publikováno v:
Cell reports. 36(9)
Fibroblasts residing in the connective tissues constitute the stem cell niche, particularly in organs such as skin. Although the effect of fibroblasts on stem cell niches and organ aging is an emerging concept, the underlying mechanisms are largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0d193ac207fd9097efb8368b1187c4
https://pubmed.ncbi.nlm.nih.gov/34469740
https://pubmed.ncbi.nlm.nih.gov/34469740
Publikováno v:
Circulation Research. 113:1102-1105
Cardiovascular diseases, such as ischemic heart disease and stroke, represent the number one cause of death worldwide.1 In most cases, atherosclerosis and hypertension constitute the underlying causes for cardiovascular disease because it leads to ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145555a890a47d350b2744533b8be62d
https://doi.org/10.1161/circresaha.113.302578
https://doi.org/10.1161/circresaha.113.302578
Autor:
Dorde Komljenovic, Jennifer Braun, Tobias Bäuerle, Marina Schorpp-Kistner, Karin Strittmatter, Melanie Sator-Schmitt, Tobias Nübel, Peter Angel
Publikováno v:
International Journal of Cancer. 134:1511-1516
The transcription factor AP-1 subunit JUNB has been shown to play a pivotal role in angiogenesis. It positively controls angiogenesis by regulating Vegfa as well as the transcriptional regulator Cbfb and its target Mmp13. In line with these findings,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a355052532b48dc1edd49a5dbd73f7e
https://doi.org/10.1002/ijc.28477
https://doi.org/10.1002/ijc.28477
Autor:
Thomas Korff, Elena Demicheva, Junhao Hu, Marina Schorpp-Kistner, Tobias Nübel, Marco Marcello, Peter Angel, Markus Hecker, Hellmut G. Augustin, Anja Feldner, Nathalie Jurisch-Yaksi, Bettina Hartenstein, Alexander H. Licht
Publikováno v:
Journal of Clinical Investigation. 120:2307-2318
Cellular contractility and, thus, the ability to alter cell shape are prerequisites for a number of important biological processes such as cytokinesis, movement, differentiation, and substrate adherence. The contractile capacity of vascular smooth mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e3a41993e5933631b1bf394a28cf0d
https://doi.org/10.1172/jci41749
https://doi.org/10.1172/jci41749
Autor:
Marina Schorpp-Kistner, Olga Keberlein, Antje Giersch, Herwig Ponstingl, Frederik Marmé, Raffael Kurek, Peter Möller, Andreas Hunziker, Claudia Müller, Jiirgen Kretschmer, Eberhard Spiess, Diethelm Wallwiener, Gerhard Moldenhauer, Uwe Hahn, Alexander Marmé, Hans-Peter Zimmermann, Gunther Bastert, Brigitte Seib, Faustino Merchán
Publikováno v:
International Journal of Cancer. 123:2048-2056
In a study on gene deregulation in ovarian carcinoma we found a mRNA coding for a 350 kDa protein, Drop1, to be downregulated 20- to 180-fold in the majority of ovarian and mammary carcinomas. The mRNA is encoded by a set of exons in the 5′ region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507d46e3e86c7b2a07d2230afcea8038
https://doi.org/10.1002/ijc.23763
https://doi.org/10.1002/ijc.23763
Autor:
Jan Tuckermann, Marina Schorpp-Kistner, Ehud Razin, Alexander H. Licht, Peter Angel, Rolf Jessberger, Björn Textor, Bettina Hartenstein
Publikováno v:
The Journal of Immunology. 179:6873-6880
Mast cells are effector cells of IgE-mediated immune responses frequently found at the vicinity of blood vessels, the margins of diverse tumors and at sites of potential infection and inflammation. Upon IgE-mediated stimulation, mast cells produce an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cab42da2b3fe4743188488f18e3951
https://doi.org/10.4049/jimmunol.179.10.6873
https://doi.org/10.4049/jimmunol.179.10.6873
Autor:
Dirk Schmidt, Alexander H. Licht, Peter Angel, Norbert E. Fusenig, Björn Textor, Marina Schorpp-Kistner, Sven Andrecht, Oliver T. Pein, Melanie Sator-Schmitt
Publikováno v:
The EMBO Journal. 26:710-719
Regulation of vascular endothelial growth factor (VEGF) expression is a complex process involving a plethora of transcriptional regulators. The AP-1 transcription factor is considered as facilitator of hypoxia-induced VEGF expression through interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5169b75448bc287499205e1e6c63dd
https://doi.org/10.1038/sj.emboj.7601539
https://doi.org/10.1038/sj.emboj.7601539
Autor:
Bettina Hartenstein, Peter Angel, Jens Kroll, Sandra J. Stoll, Laura Gutierrez Miranda, Marina Schorpp-Kistner, Katrin Bennewitz, Kristin Kiesow
Publikováno v:
Scientific Reports
JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli. Previously, JUNB was shown to act as a critical positive regulator of blood vessel development and homeostasis as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b784cb8546f5aa001577e90f3765b22e
http://europepmc.org/articles/PMC4602192
http://europepmc.org/articles/PMC4602192