N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Autor: Ana Perez-Castillo, Marina Sanz-SanCristobal, Jordi Riba, Sandra Alonso-Gil, José A. Morales-García, Javier Calleja-Conde, José Antonio López-Moreno

Publikováno v: Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-14 (2020)
Translational Psychiatry, 10(1):331. Nature Publishing Group

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8583479069c3311783decebb0588ce53
http://europepmc.org/articles/PMC7522265

Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.

Autor: Diana Aguilar-Morante, Jose Angel Morales-Garcia, Marina Sanz-SanCristobal, Miguel Angel Garcia-Cabezas, Angel Santos, Ana Perez-Castillo

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13879 (2010)

Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3β (GSK-3β). In this study, we analyzed the effects of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-

Externí odkaz: https://doaj.org/article/609a34d1bb4a4fd18a3643e31399bafc

Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ

Autor: José A. Morales-García, Ana Perez-Castillo, Angel Santos, Marina Sanz-SanCristobal, Elena Hernandez-Encinas, Elena Giné, Diana Aguilar-Morante

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Neuroinflammation

[Background] The CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor implicated in the control of proliferation, differentiation, and inflammatory processes mainly in adipose tissue and liver; although more recent results have revea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71af51a7082a3558add675f95eed5491
http://hdl.handle.net/10261/143371

The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

Autor: Cristina, Susín, Jose A, Morales-Garcia, Diana, Aguilar-Morante, Valle, Palomo, Marina, Sanz-Sancristobal, Sandra, Alonso-Gil, Carmen, Gil, Angel, Santos, Ana, Martinez, Ana, Perez-Castillo

Publikováno v: Journal of neurochemistry. 122(6)

Increased levels of glutamate causing excitotoxic damage accompany many neurological disorders. A well-characterized model of excitotoxic damage involves administration of kainic acid (KA), which causes limbic seizure activity and subsequent neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a0b7f2d65e7a88baac1bd64ae064b95
https://pubmed.ncbi.nlm.nih.gov/22774807

Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells

Autor: Angel Santos, Ana Perez-Castillo, Marta Cortes-Canteli, Marina Sanz-SanCristobal, Diana Aguilar-Morante

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

C/EBPβ is a leucine-zipper transcription factor implicated in the control of metabolism, development, cell differentiation, and proliferation. However, it remains unclear its role in tumor development. Here, we show that down-regulation of C/EBPβ b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018ea35603497cc1dc77495845d144d3
http://hdl.handle.net/10261/76671