Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas

Autor: Marina Salmón, Ruth Álvarez-Díaz, Coral Fustero-Torre, Oksana Brehey, Carmen G. Lechuga, Manuel Sanclemente, Fernando Fernández-García, Alejandra López-García, María Carmen Martín-Guijarro, Sandra Rodríguez-Perales, Emily Bousquet-Mur, Lucía Morales-Cacho, Francisca Mulero, Fátima Al-Shahrour, Lola Martínez, Orlando Domínguez, Eduardo Caleiras, Sagrario Ortega, Carmen Guerra, Monica Musteanu, Matthias Drosten, Mariano Barbacid

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)

KRASG12C inhibitors have revolutionized the clinical management of patients with KRASG12C-mutant lung adenocarcinoma. However, patient exposure to these inhibitors leads to the rapid onset of resistance. In this study, we have used genetically engine

Externí odkaz: https://doaj.org/article/a51ce49b33904d3e80b5fe3757365959

RASless MEFs as a Tool to Study RAS-Dependent and RAS-Independent Functions

Autor: Carmen G, Lechuga, Marina, Salmón, Guillem, Paniagua, Carmen, Guerra, Mariano, Barbacid, Matthias, Drosten

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2262

RAS proteins are key players in multiple cellular processes. To study the role of RAS proteins individually or in combination, we have developed MEFs that can be rendered RASless, i.e., devoid of all endogenous RAS isoforms. These cells have signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51ecd670f11ca2dc3eee32c1d0d9d22d
https://pubmed.ncbi.nlm.nih.gov/33977488

KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform

Autor: Guillem Paniagua, Eduardo Caleiras, Carmen G. Lechuga, Carmen Guerra, Fernando Fernández-García, Marina Salmón, Matthias Drosten, Monica Musteanu, Eduardo Zarzuela, Ruth Álvarez-Díaz, Mariano Barbacid, Sagrario Ortega, Javier Muñoz

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Proc Natl Acad Sci U S A

In mammals, the KRAS locus encodes two protein isoforms, KRAS4A and KRAS4B, which differ only in their C terminus via alternative splicing of distinct fourth exons. Previous studies have shown that whereas KRAS expression is essential for mouse devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60838ee66824970e27815dd3523d9de7
http://hdl.handle.net/20.500.12105/14703

Desertomycin G, a new antibiotic with activity against mycobacterium tuberculosis and human breast tumor cell lines produced by streptomyces althioticus MSM3, isolated from the cantabrian sea intertidal macroalgae ulva sp

Autor: Luis A. García, Ignacio Pérez-Victoria, Juan José Palacios-Gutiérrez, Marina Salmón, Yamina Mohamedi, Luis Otero, Alfredo F. Braña, Aida Sarmiento-Vizcaíno, Jonathan Fernández, Tania Fontanil, Jesús Martín, Fernando Reyes, Santiago Cal, Gloria Bianco

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Marine Drugs
Marine Drugs, Vol 17, Iss 2, p 114 (2019)
Volume 17
Issue 2

This study was financially supported by the Universidad de Oviedo (UNOV-11-MA-02) and Gobierno del Principado de Asturias (SV-PA-13-ECOEMP-62). The polarimeter, IR, and NMR equipment used in this work were acquired via grants for scientific and techn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66223b1160b32f89bf26d58daaf52528
http://hdl.handle.net/10651/51810

NMR and X-ray study of cyclotetraveratrilene derivatives

Autor: G. Espinosa Pérez, S. Hernandez Ortega, Raymundo Cruz-Almanza, F. Lara Ochoa, M.I. Chávez Uribe, P. Arroyo Ortega, Marina Salmón, M. Martínez García

Publikováno v: Tetrahedron. 53:17633-17642

A conformational study of cycloveratrilenes 3 and 4 by high resolution NMR at low temperature for 3 and room temperature for 4 along with X-ray crystallography is reported. From these experiments we found a dynamic process, where magnetic and topolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92d7a726e66a5b56297f4cca6d6ce70c
https://doi.org/10.1016/s0040-4020(97)10232-0