Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marina Roell"'
Publikováno v:
Journal of Cellular Biochemistry. 116:2109-2119
It has been proposed that monoclonal antibodies may become therapeutics for metabolic diseases such as diabetes mellitus. We have previously characterized an allosteric monoclonal antibody to the human insulin receptor (IR), XMetA, that activated met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d306f84045c13947d04a5190761ae351
https://doi.org/10.1002/jcb.25168
https://doi.org/10.1002/jcb.25168
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:202-215
Interleukin-1β (IL-1β) is a proinflammatory cytokine that is implicated in many autoinflammatory disorders, but is also important in defense against pathogens. Thus, there is a need to safely and effectively modulate IL-1β activity to reduce patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b9a93b3418c1f59583d657cd68ecb3
https://doi.org/10.1124/jpet.113.205443
https://doi.org/10.1124/jpet.113.205443
Autor:
Paul D. Larsen, Alexander Owyang, Elizabeth Pongo, Marina Roell, Mary Haak-Frendscho, Masahisa Handa, Linda Masat, Hassan Issafras, Kiran Ahluwalia, John Corbin, Arnold Horwitz
Publikováno v:
mAbs. 3:49-60
Interleukin-1β (IL-1β) is a potent mediator of inflammatory responses and plays a role in the differentiation of a number of lymphoid cells. In several inflammatory and autoimmune diseases, serum levels of IL-1β are elevated and correlate with dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa69ccd08b967c0e590adbe4bb95db65
https://doi.org/10.4161/mabs.3.1.13989
https://doi.org/10.4161/mabs.3.1.13989
Autor:
John Corbin, Steve R. Lee, Naichi Liu, Paul D. Larsen, Nerissa Mendoza, Alexander Owyang, Genevieve Nonet, Kristen Michelson, David J. Bohmann, Amer M. Mirza, Hassan Issafras, Sandra Vanegas, Mark L. White, Daniel Bedinger, Seema S. Kantak, Robert J. Bauer, Masahisa Handa, Arnold Horwitz, Marina Roell, Lisa Gross, John J. Hunter
Publikováno v:
Journal of Biological Chemistry. 285:20607-20614
Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of monoclonal antibodies based on context-dependent attenuation to reduce pathologically high acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77194264fd73d946d170c670a65fe525
https://doi.org/10.1074/jbc.m110.115790
https://doi.org/10.1074/jbc.m110.115790
Autor:
Paul D. Larsen, Amita Patel, Susan J. Babuka, Jeremy Kam-Kuen Ma, Ssucheng J. Hsu, Robert J. Bauer, Marina Roell, Linda Masat, Mary Haak-Frendscho, David J. Bohmann, Rhonda K. Hansen, Mark L. White
Publikováno v:
Biochemical Pharmacology. 76:340-352
The peptide hormone gastrin is a key factor in regulation of gastric acid secretion. It has also been implicated in the development or maintenance of various types of cancer, such as pancreatic and stomach carcinoma. Inhibition of gastrin activity ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80183c953125e995407950e1a2ee4fc
https://doi.org/10.1016/j.bcp.2008.05.015
https://doi.org/10.1016/j.bcp.2008.05.015
Kinetic analysis of a high-affinity antibody/antigen interaction performed by multiple Biacore users
Autor:
David G. Myszka, John Whatley, Gisele A. Tavares, Kevin Thornton, Della Friend, Ergang Shi, Scott L. Klakamp, Larry Rose, Linsey Fan, Béatrice Luginbühl, Angela Widom, Iva Navratilova, Ite A. Laird-Offringa, Bruce Roth, David J. Bohmann, Jill Dorocke, Carla Forte, Andrew W. Drake, Kevin Lindquist, Mingde Zhu, Tim Vanden Bos, Marina Roell, Phinikoula S. Katsamba, Maria Calderon-Cacia
Publikováno v:
Analytical biochemistry. 352(2)
To explore the reliability of Biacore-based assays, 22 study participants measured the binding of prostate-specific antigen (PSA) to a monoclonal antibody (mAb). Each participant was provided with the same reagents and a detailed experimental protoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6e41c983b851d0ac554ecb53d18dfb
https://pubmed.ncbi.nlm.nih.gov/16564019
https://pubmed.ncbi.nlm.nih.gov/16564019
Autor:
Lin Esposito, Mary Haak-Frendscho, Marina Roell, Paul D. Larsen, John Corbin, Seema Kantak, Alexander Owyang, Elizabeth Pongo, Nathalie Dubois-Stringfellow, David G. Alleva, Linda Masat, Arnold Horwitz, Kiran Ahluwalia, Sandra Vanegas
Publikováno v:
Clinical Immunology. 127:S98-S99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051c5cf93854a7a8b6940ff59bd4d030
https://doi.org/10.1016/j.clim.2008.03.277
https://doi.org/10.1016/j.clim.2008.03.277