Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Marina R. Kasimova"'
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133584 (2015)
PEGylation is a strategy used by the pharmaceutical industry to prolong systemic circulation of protein drugs, whereas formulation excipients are used for stabilization of proteins during storage. Here we investigate the role of PEGylation in protein
Externí odkaz:
https://doaj.org/article/071be03b3b0f4f6abe3b7371a920b8ee
Autor:
Richard A. Campbell, Maria Høtoft Michaelsen, Tania Kjellerup Lind, Henrik Franzyk, Marité Cárdenas, Marina R. Kasimova, Lene Jorgensen, Sofie Fogh Hedegaard, Malene Vinther Christensen, Hanne Mørck Nielsen, Mohammed Sobhi Derbas
Publikováno v:
Hedegaard, S F, Derbas, M S, Lind, T K, Kasimova, M R, Christensen, M V, Michaelsen, M H, Campbell, R A, Jorgensen, L, Franzyk, H, Cárdenas, M & Nielsen, H M 2018, ' Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction ', Scientific Reports, vol. 8, no. 1, 6327 . https://doi.org/10.1038/s41598-018-24154-z
'Scientific Reports ', vol: 8, pages: 6327-1-6327-14 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
'Scientific Reports ', vol: 8, pages: 6327-1-6327-14 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
The demand for highly efficient macromolecular drugs, used in the treatment of many severe diseases, is continuously increasing. However, the hydrophilic character and large molecular size of these drugs significantly limit their ability to permeate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866e0a73d5364d65061986e5097638ae
https://curis.ku.dk/portal/da/publications/fluorophore-labeling-of-a-cellpenetrating-peptide-significantly-alters-the-mode-and-degree-of-biomembrane-interaction(c51e3bc5-2609-4e95-ac13-d9b87e28595e).html
https://curis.ku.dk/portal/da/publications/fluorophore-labeling-of-a-cellpenetrating-peptide-significantly-alters-the-mode-and-degree-of-biomembrane-interaction(c51e3bc5-2609-4e95-ac13-d9b87e28595e).html
Autor:
Theodore W. Randolph, Marina R. Kasimova, Jakob E. Rasmussen, Aaron C. McUmber, Marco van de Weert, Marc Obiols-Rabasa, Louise Holm, Peter W. Thulstrup
Publikováno v:
Journal of Pharmaceutical Sciences. 103:3043-3054
The presence of micron aggregates in protein formulations has recently attracted increased interest from regulatory authorities, industry, and academia because of the potential undesired side effects of their presence. In this study, we characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf92cbfae1ff09a79e1885e604ef1532
https://doi.org/10.1002/jps.24094
https://doi.org/10.1002/jps.24094
Autor:
Camilla Foged, Lene Jorgensen, Henrik Franzyk, Hanne Mørck Nielsen, Mingjun Yang, Xiaona Jing, Marina R. Kasimova, Martin Malmsten
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818:2660-2668
Cell-penetrating peptides (CPPs) provide a promising approach for enhancing intracellular delivery of therapeutic biomacromolecules by increasing transport through membrane barriers. Here, proteolytically stable cell-penetrating peptidomimetics with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659d82bb8ea4cde14d80eb351f81c1cf
https://doi.org/10.1016/j.bbamem.2012.05.003
https://doi.org/10.1016/j.bbamem.2012.05.003
Autor:
Camilla Foged, Giovanni M. Pavan, Hanne Mørck Nielsen, Sandra Rutherford, Marina R. Kasimova, Linda Jensen, Andrea Danani
Publikováno v:
International Journal of Pharmaceutics. 416:410-418
Dendrimers are attractive vehicles for nucleic acid delivery due to monodispersity and ease of chemical design. The purpose of this study was to elucidate the self-assembly process between small interfering RNA (siRNA) and different generation poly(a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cac5d928b43952dff6c295699fc770
https://doi.org/10.1016/j.ijpharm.2011.03.015
https://doi.org/10.1016/j.ijpharm.2011.03.015
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 79:1747-1758
The chaperone-like protein α-crystallin is a ∼35 subunit hetero-oligomer consisting of αA and αB subunits in a 3:1 molar ratio and has the function of maintaining eye lens transparency. We studied the thermal denaturation of α-crystallin by dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d28871561b14a5ac542d7fb528d27a
https://doi.org/10.1002/prot.22998
https://doi.org/10.1002/prot.22998
Autor:
Veronika Gadzhyeva, Ditte Krohn Jensen, Giovanni M. Pavan, Kell Mortensen, Hanne Mørck Nielsen, Camilla Foged, Marina R. Kasimova, Linda Jensen
Publikováno v:
Biomacromolecules. 11:3571-3577
A prerequisite for the use of dendrimers as drug delivery vehicles is the detailed molecular understanding of the drug interaction. The purpose of this study was to characterize the self-assembly process between siRNA and generation 7 poly(amidoamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872273361f3d87c2bdcdd7f21a0b36d2
https://doi.org/10.1021/bm101033g
https://doi.org/10.1021/bm101033g
Publikováno v:
Biochemistry. 48:9313-9320
The protein alpha-crystallin, a member of the small heat shock protein family, has the ability to prevent aggregation of partially denatured proteins, an effect demonstrated both in vivo and in vitro. In this work, we have probed the apparent thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18b9d100caef47f568a032f804d9ead
https://doi.org/10.1021/bi900451j
https://doi.org/10.1021/bi900451j
Autor:
Marina R. Kasimova, Peter Hagedorn, Ian M. Møller, Jurga Grigiene, Klaas Krab, Henrik Flyvbjerg, Peter Andersen
Publikováno v:
Proceedings of SPIE-International Society for Optical Engineering, 5322, 42-51. SPIE
Kaimava, M R, Krab, K, Grigiene, J, Andersen, P E, Hagedorn, P, Flyvbjerg, H K & Moller, I M 2004, ' Quantitative distinction between bound and free NADH in biological systems. ', Proceedings of SPIE-International Society for Optical Engineering, vol. 5322, pp. 42-51 . https://doi.org/10.1117/12.527392
Kaimava, M R, Krab, K, Grigiene, J, Andersen, P E, Hagedorn, P, Flyvbjerg, H K & Moller, I M 2004, ' Quantitative distinction between bound and free NADH in biological systems. ', Proceedings of SPIE-International Society for Optical Engineering, vol. 5322, pp. 42-51 . https://doi.org/10.1117/12.527392
Without exceptions, in all living cells NADH is a key metabolite linking a large number of metabolic pathways. Flux rates through such pathways are an essential component in the understanding of the functioning of living cells. Knowledge about the wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc3df68e09f9d37f715879054c86930
https://hdl.handle.net/1871.1/a3434486-aad8-43f4-931b-f912e1b7cf44
https://hdl.handle.net/1871.1/a3434486-aad8-43f4-931b-f912e1b7cf44
Autor:
Lene Jorgensen, Xiaona Jing, Hanne Mørck Nielsen, Marina R. Kasimova, Anders Simonsen, Martin Malmsten, Camilla Foged, Henrik Franzyk
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 28(11)
Enzymatically stable cell-penetrating α-peptide/β-peptoid peptidomimetics constitute promising drug delivery vehicles for the transport of therapeutic biomacromolecules across membrane barriers. The aim of the present study was to elucidate the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1688e1e3001d9f4431e2e96b8e6083b5
https://pubmed.ncbi.nlm.nih.gov/22339375
https://pubmed.ncbi.nlm.nih.gov/22339375