Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.

Autor: Martin Kongsbak, Marina R von Essen, Lasse Boding, Trine B Levring, Peter Schjerling, Jens P H Lauritsen, Anders Woetmann, Niels Ødum, Charlotte M Bonefeld, Carsten Geisler

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96695 (2014)

The active form of vitamin D3, 1,25(OH)2D3, has significant immunomodulatory properties and is an important determinant in the differentiation of CD4+ effector T cells. The biological actions of 1,25(OH)2D3 are mediated by the vitamin D receptor (VDR

Externí odkaz: https://doaj.org/article/86101359e9394e54b78d1ec87358bc0a

Relationship between cerebrospinal fluid biomarkers of inflammation and tissue damage in primary progressive multiple sclerosis

Autor: Jacob Talbot, Helene Højsgaard Chow, Mie Mahler, Sophie Buhelt, Rikke Holm Hansen, Henrik Lundell, Tua Vinther-Jensen, Marie N.N. Hellem, Jørgen E. Nielsen, Hartwig Roman Siebner, Marina R. von Essen, Finn Sellebjerg

Publikováno v: Talbot, J, Højsgaard Chow, H, Mahler, M, Buhelt, S, Holm Hansen, R, Lundell, H, Vinther-Jensen, T, Hellem, M N N, Nielsen, J E, Siebner, H R, von Essen, M R & Sellebjerg, F 2022, ' Relationship between cerebrospinal fluid biomarkers of inflammation and tissue damage in primary progressive multiple sclerosis ', Multiple Sclerosis and Related Disorders, vol. 68, 104209 . https://doi.org/10.1016/j.msard.2022.104209

Background and Objectives: It is unclear to what extent intrathecal inflammation contributes to the pathogenesis in primary progressive multiple sclerosis (PPMS). We conducted an exploratory study to investigate the degree of intrathecal inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccf2d47038048d606c060066ecb6a0f
https://curis.ku.dk/ws/files/323995524/1_s2.0_S2211034822007143_main.pdf

Smoking reduces circulating CD26

Autor: Cecilie, Ammitzbøll, Lars, Börnsen, Jeppe, Romme Christensen, Rikke, Ratzer, Birgitte, Romme Nielsen, Helle B, Søndergaard, Marina R, von Essen, Finn, Sellebjerg

Publikováno v: Journal of leukocyte biology. 101(5)

Upon chronic cigarette smoke exposure, inhaled antigens and irritants cause altered lung immune homeostasis. Circulating immune cells are affected, and smoking is associated with an increased risk of developing various disorders, including multiple s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6f498836e4187ef8ecdca8bee4b0e4
https://pubmed.ncbi.nlm.nih.gov/28179539

IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis

Autor: Marina R. von Essen, Helle B. Søndergaard, Eva R.S. Petersen, Finn Sellebjerg

Publikováno v: Cells, Vol 8, Iss 3, p 285 (2019)

Multiple sclerosis (MS) is an immune-mediated demyelinating disease characterized by central nervous system (CNS) lymphocyte infiltration, abundant production of pro-inflammatory cytokines, and inappropriate activation of Th1 and Th17 cells, B cells,

Externí odkaz: https://doaj.org/article/f117c038054942849e11b1ed43268ac2