Mitochondrial Dysfunction in Dopaminergic Neurons Derived from Patients with LRRK2- and SNCA-Associated Genetic Forms of Parkinson’s Disease

Autor: Anna S. Vetchinova, Marina R. Kapkaeva, Mikhail V. Ivanov, Kristina A. Kutukova, Natalia M. Mudzhiri, Lydia E. Frumkina, Anatoly V. Brydun, Vladimir S. Sukhorukov, Sergey N. Illarioshkin

Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 8395-8411 (2023)

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Some cases of PD may be caused by genetic factors, among which mutations in the LRRK2 and SNCA genes play an important role. To develop effective neuroprotective strategi

Externí odkaz: https://doaj.org/article/92addc3dbffb49a99bb77514da92d9d0

Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions

Autor: Natalia R. Onishchenko, Alexey A. Moskovtsev, Maria K. Kobanenko, Daria S. Tretiakova, Anna S. Alekseeva, Dmitry V. Kolesov, Anna A. Mikryukova, Ivan A. Boldyrev, Marina R. Kapkaeva, Olga N. Shcheglovitova, Nicolai V. Bovin, Aslan A. Kubatiev, Olga V. Tikhonova, Elena L. Vodovozova

Publikováno v: Pharmaceutics, Vol 15, Iss 6, p 1754 (2023)

Previously, we showed in the human umbilical vein endothelial cells (HUVECs) model that a liposome formulation of melphalan lipophilic prodrug (MlphDG) decorated with selectin ligand tetrasaccharide Sialyl Lewis X (SiaLeX) undergoes specific uptake b

Externí odkaz: https://doaj.org/article/f7f68554b7634b1e86713e7a8d0e8ddb

Novel Approaches Used to Examine and Control Neurogenesis in Parkinson′s Disease

Autor: Sergey N. Illarioshkin, Alla B. Salmina, Marina R Kapkaeva, Anna S Vetchinova

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9608, p 9608 (2021)
International Journal of Molecular Sciences

Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in chronic neurodegeneration, including Parkinson’s disease. The accumulation of aberrant α-synuclein is one of the features of PD. Being secreted, this protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7dca1caed56e8e2ce9312d71c00573
https://www.mdpi.com/1422-0067/22/17/9608

Topical treatment with the bacterium-derived c-Met agonist InlB

Autor: Yaroslava M, Chalenko, Elena V, Sysolyatina, Konstantin A, Sobyanin, Marina R, Kapkaeva, Alexandra, Lavrikova, Egor, Kalinin, Olga N, Scheglovitova, Svetlana A, Ermolaeva

Publikováno v: Archives of dermatological research. 310(10)

Studies of factors affecting wound-healing rates are encouraged by a critical need for new treatments to manage an increasing burden of non-healing wounds. The InlB protein produced by the Gram-positive bacterium Listeria monocytogenes is an agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7189ad0c12b9da3d3deaa62deda5dc32
https://pubmed.ncbi.nlm.nih.gov/30306262

Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions.

Autor: Onishchenko, Natalia R.¹ (AUTHOR) natalia.r.onishchenko@gmail.com, Moskovtsev, Alexey A.² (AUTHOR), Kobanenko, Maria K.¹ (AUTHOR), Tretiakova, Daria S.¹ (AUTHOR), Alekseeva, Anna S.¹ (AUTHOR), Kolesov, Dmitry V.² (AUTHOR), Mikryukova, Anna A.² (AUTHOR), Boldyrev, Ivan A.¹ (AUTHOR), Kapkaeva, Marina R.³ (AUTHOR), Shcheglovitova, Olga N.³ (AUTHOR), Bovin, Nicolai V.¹ (AUTHOR), Kubatiev, Aslan A.² (AUTHOR), Tikhonova, Olga V.⁴ (AUTHOR), Vodovozova, Elena L.¹ (AUTHOR) elvod.ibch@yandex.ru

Publikováno v: Pharmaceutics. Jun2023, Vol. 15 Issue 6, p1754. 25p.