Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Marina Porcelloni"'
Autor:
Marina Porcelloni, Elena Marastoni, Maria Altamura, Rose-Marie Catalioto, Sandro Giuliani, Carlo Alberto Maggi, Sandro Mauro, Stefania Meini, Cristina Rossi, Piero D’Andrea, Alessandro Ettorre, Daniela Fattori
Publikováno v:
Journal of Medicinal Chemistry. 53:4148-4165
As part of a project aimed at the identification of a series of small, orally available antagonists for the hNK(2) receptor, starting from one of our capped dipeptide libraries, we succeeded in the chemical optimization of the first identified leads,
Autor:
Marina Porcelloni, Stefania Meini, Andrea Madami, Sandro Giuliani, Maria Altamura, Cristina Rossi, Alessandro Ettorre, Daniela Fattori, Alessandro Sisto, Piero D’Andrea
Publikováno v:
ChemMedChem. 3:1048-1060
The NK(2) receptor belongs to the family of tachykinin neurotransmitters. It has been reported to be involved in several pathological conditions, and selective antagonists are potentially useful drugs for the treatment of asthma, irritable bowel synd
Publikováno v:
Journal of Medicinal Chemistry. 51:1505-1529
Autor:
Jonathan P. H. Charmant, Marina Porcelloni, Varinder K. Aggarwal, Leo Dudin, Jeffery Richardson
Publikováno v:
Proceedings of the National Academy of Sciences. 101:5467-5471
Bridged bicyclic sulfide 1 was originally found to provide high levels of asymmetric induction in sulfur ylide-mediated epoxidations. This sulfide possesses chirality in the [2.2.1] thioether moiety and the [2.2.1] camphor-derived carbocyclic moiety.
Publikováno v:
Tetrahedron Letters. 44:811-814
A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are release
Autor:
Piero D’Andrea, Alessandro Ettorre, Rose Marie Catalioto, Maria Altamura, Sandro Giuliani, Carlo Alberto Maggi, Sandro Mauro, Daniela Fattori, Cristina Rossi, Marina Porcelloni
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1807-1809
Starting from in-house capped tripeptide libraries, we have developed two series of compounds as potent antagonists of the hNK2 receptor with a reduced peptide character. These two series maintained a crucial amide bond, which could not be methylated
Autor:
Sandra Bartoli, Amalia Cipollone, Mario Bigioni, Marco Berettoni, Alessandro Ettorre, Carlo Alberto Maggi, Christopher I. Fincham, Federica Nardelli, Marina Porcelloni, Daniela Fattori, Paola Paoli, Patrizia Rossi, Monica Binaschi, Sandro Mauro, Marielle Paris, Elena Marastoni, Massimo Parlani
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(7)
In the search for a new class of histone deacetylase inhibitors, we prepared a series of very simple benzofused hydroxamic acids to find an anchoring fragment of minimal molecular weight: they showed very good ligand efficiencies. Following these fin
Autor:
Marina Porcelloni, Varinder K. Aggarwal, Guangyu Fang, Emma Alonso, Marco Ferrara, George Hynd
Publikováno v:
Angewandte Chemie. 113:1482-1485
Autor:
Marina Porcelloni, John Studley, George Hynd, Kevin M. Lydon, Varinder K. Aggarwal, Emma Alonso, Matthew J. Palmer
Publikováno v:
Angewandte Chemie. 113:1479-1482
Publikováno v:
The Journal of Organic Chemistry. 63:804-807
A novel palladium(0)-catalyzed cyclization to 3,4-disubstituted pyrrolidin-2-ones has been developed. The new approach relies upon the concomitant generation of stabilized acetamide enolate anions and of a π-allyl−palladium appendage, properly tet