Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marina P di Magliano"'
Autor:
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 475-505 (2024)
Abstract We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancr
Externí odkaz:
https://doaj.org/article/d6378f109e874a1da4c8222d7dc3b37c
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, it provides an overview of the
Externí odkaz:
https://doaj.org/article/344459dd376541a590c5e371cdc24824
Autor:
Ashley M. Mello, Tenzin Ngodup, Yusoo Lee, Katelyn L. Donahue, Jinju Li, Arvind Rao, Eileen S. Carpenter, Howard C. Crawford, Marina Pasca di Magliano, Kyoung Eun Lee
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-9 (2022)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability or hypoxia. Cancer-associated fibroblasts (CAF) are a predominant and hete
Externí odkaz:
https://doaj.org/article/58ecf0cb5fb64401ae4dd519669818f1
Autor:
Juan J Apiz Saab, Lindsey N Dzierozynski, Patrick B Jonker, Roya AminiTabrizi, Hardik Shah, Rosa Elena Menjivar, Andrew J Scott, Zeribe C Nwosu, Zhou Zhu, Riona N Chen, Moses Oh, Colin Sheehan, Daniel R Wahl, Marina Pasca di Magliano, Costas A Lyssiotis, Kay F Macleod, Christopher R Weber, Alexander Muir
Publikováno v:
eLife, Vol 12 (2023)
Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is criti
Externí odkaz:
https://doaj.org/article/c5f718ce140e4a6fa50f1ed1f45d288d
Autor:
Rosa E Menjivar, Zeribe C Nwosu, Wenting Du, Katelyn L Donahue, Hanna S Hong, Carlos Espinoza, Kristee Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison Bischoff, Padma Kadiyala, Daniel Salas-Escabillas, Howard C Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J Halbrook, Costas A Lyssiotis, Marina Pasca di Magliano
Publikováno v:
eLife, Vol 12 (2023)
An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms
Externí odkaz:
https://doaj.org/article/2b78244f89f74a1a8452e4521a5af646
Autor:
Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca di Magliano, Kai Ge, Yali Dou, Jiaqi Shi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 643-667 (2022)
Background & Aims: Inactivating mutations of KDM6A, a histone demethylase, were frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role of KDM6A (lysine demethylase 6A) in PDAC development. Methods: We performed a pancre
Externí odkaz:
https://doaj.org/article/30accdb06dbc4b8cb39215d81b9ed199
Autor:
Angela J. Mathison, Romica Kerketta, Thiago Milech de Assuncao, Elise Leverence, Atefeh Zeighami, Guillermo Urrutia, Timothy J. Stodola, Marina Pasca di Magliano, Juan L. Iovanna, Michael T. Zimmermann, Gwen Lomberk, Raul Urrutia
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. Results Here, we apply biological, biochemical, and network biology methods to validate GEMM-derived cell models using inducible KrasG12D exp
Externí odkaz:
https://doaj.org/article/ef75ec357b034f33b2c29cbe89799f9e
Autor:
Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
Externí odkaz:
https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e5
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1531-1542 (2021)
Pancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloi
Externí odkaz:
https://doaj.org/article/c6ea5886473b4e40acf34f6c756e6adf
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
A challenge in cancer treatment is targeting cancer cells while sparing normal cells. Thus, identifying cancer-specific neoepitopes is an active research area. Neoepitopes are generated by the accumulation of mutations; however, deadly cancer types,
Externí odkaz:
https://doaj.org/article/f640bbf642394ddf97712c828bce657c