Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Marina Nozawa"'
Autor:
Masaru Mori, Marina Nozawa, Junichi Goto, Nariyasu Mano, Miki Shimada, Katsuhiro Kanda, Hiroaki Yamaguchi, Mayumi Sato, Makoto Nogami
Publikováno v:
Journal of Chromatography B. 879:968-974
Ion suppression can negatively affect the performance characteristics of LC/ESI-MS/MS based methods, and we wished to identify sources of ion suppression in an assay for quantitating sirolimus in human whole blood. We first compared the peak areas of
Autor:
Nariyasu Mano, Hiroaki Yamaguchi, Masaru Mori, Yotaro Matsumoto, Junichi Goto, Mayumi Sato, Miki Shimada, Marina Nozawa
Publikováno v:
Journal of Chromatography B. 879:987-992
Sirolimus is a widely used immunosuppressant that requires therapeutic drug monitoring (TDM). We optimized a preanalytical procedure that allows for the accurate quantiation of sirolimus in whole blood by LC/ESI-MS/MS with minimal matrix effects. Sir