Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Marina N. Sharifi"'
1
Akademický článek
A phenocopy signature of TP53 loss predicts response to chemotherapy
Autor: Hamza Bakhtiar, Marina N. Sharifi, Kyle T. Helzer, Yue Shi, Matthew L. Bootsma, Tianfu A. Shang, Matthew R. Chrostek, Tracy J. Berg, S. Carson Callahan, Viridiana Carreno, Grace C. Blitzer, Malinda T. West, Ruth M. O’Regan, Kari B. Wisinski, Martin Sjöström, Shuang G. Zhao
Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024)
Abstract In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In
Externí odkaz: https://doaj.org/article/b735ca97c9414b91b5344298927abc08
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2
Akademický článek
A platform-independent AI tumor lineage and site (ATLAS) classifier
Autor: Nicholas R. Rydzewski, Yue Shi, Chenxuan Li, Matthew R. Chrostek, Hamza Bakhtiar, Kyle T. Helzer, Matthew L. Bootsma, Tracy J. Berg, Paul M. Harari, John M. Floberg, Grace C. Blitzer, David Kosoff, Amy K. Taylor, Marina N. Sharifi, Menggang Yu, Joshua M. Lang, Krishnan R. Patel, Deborah E. Citrin, Kaitlin E. Sundling, Shuang G. Zhao
Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independent
Externí odkaz: https://doaj.org/article/27df8447126a4b8db5d9d92bb0d0f133
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3
Akademický článek
A phase I study of talazoparib (BMN 673) combined with carboplatin and paclitaxel in patients with advanced solid tumors (NCI9782)
Autor: Ticiana A. Leal, Marina N. Sharifi, Nancy Chan, Robert Wesolowski, Anita A. Turk, Justine Y. Bruce, Ruth M. O'Regan, Jens Eickhoff, Lisa M. Barroilhet, Jyoti Malhotra, Janice Mehnert, Eugenia Girda, Elizabeth Wiley, Natalie Schmitz, Shannon Andrews, Glenn Liu, Kari B. Wisinski
Publikováno v: Cancer Medicine, Vol 11, Iss 21, Pp 3969-3981 (2022)
Abstract Background Inhibitors of poly(ADP‐ribose) polymerase (PARP) proteins potentiate antitumor activity of platinum chemotherapy. This study sought to determine the safety and tolerability of PARP inhibitor talazoparib with carboplatin and pacl
Externí odkaz: https://doaj.org/article/d110893465fc4eceb9dd0c7b44d3c53f
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4
Akademický článek
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3
Autor: Marina N. Sharifi, Erin E. Mowers, Lauren E. Drake, Chris Collier, Hong Chen, Marta Zamora, Stephanie Mui, Kay F. Macleod
Publikováno v: Cell Reports, Vol 15, Iss 8, Pp 1660-1672 (2016)
Autophagy is a conserved catabolic process that plays a housekeeping role in eliminating protein aggregates and organelles and is activated during nutrient deprivation to generate metabolites and energy. Autophagy plays a significant role in tumorige
Externí odkaz: https://doaj.org/article/7173544fe7104a31966740b4c6573eed
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5
Akademický článek
Autophagic degradation of focal adhesions underlies metastatic cancer dissemination
Autor: Marina N. Sharifi, Erin E. Mowers, Kay F. Macleod
Publikováno v: Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)
Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct inte
Externí odkaz: https://doaj.org/article/ff8f41993646426abf669b6664eecfdd
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6
Abstract P1-13-14: Increased androgen receptor expression as a mechanism of acquired anti-androgen resistance in androgen receptor-positive triple negative breast cancer
Autor: Hannah Krause, Marina N. Sharifi, Serena K. Wolfe, Jamie M. Sperger, Kari B. Wisinski, Ruth O’Regan, Joshua Lang
Publikováno v: Cancer Research. 83:P1-13
Background: Triple negative breast cancer (TNBC) represents the most aggressive breast cancer subtype, and despite recent treatment advances, clinical outcomes remain poor, particularly in the metastatic setting. TNBC is a biologically heterogeneous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cab4ba9cda2d5b1fe2ac26e124e05f7
https://doi.org/10.1158/1538-7445.sabcs22-p1-13-14
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8
Abstract PS5-35: Detection of PI3K pathway activation in circulating tumor cells in PIK3CA mutated metastatic breast cancer as a putative predictive biomarker for PI3K inhibitor therapies
Autor: Cole Gilsdorf, Ruth O'Regan, Amanda Parkes, Marina N. Sharifi, Jamie M. Sperger, Joshua M. Lang, Serena K. Wolfe, Kari B. Wisinski
Publikováno v: Cancer Research. 81:PS5-35
Background: Somatic genomic alterations that activate the phosphatidylinositol-3-kinase (PI3K) pathway signaling are found in 30-50% of breast cancers, and the p110a-specific inhibitor alpelisib is approved for use in combination with fulvestrant in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7949f34db1f4f3b15323dd82c934bb6f
https://doi.org/10.1158/1538-7445.sabcs20-ps5-35
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