Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marina Mitsui"'
Autor:
Hiroshi Suemizu, Megumi Nishiwaki, Marina Mitsui, Hiroshi Yamazaki, Miho Yamazaki-Nishioka, Makiko Shimizu
Publikováno v:
Xenobiotica. 48:117-123
1. Benzydamine is used clinically as a nonsteroidal anti-inflammatory drug in oral rinses and is employed in preclinical research as a flavin-containing monooxygenase (FMO) probe substrate. In this study, plasma concentrations of benzydamine and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8044d04db87db7f7ce6d1404d89ab967
https://doi.org/10.1080/00498254.2017.1288280
https://doi.org/10.1080/00498254.2017.1288280
Autor:
Masahiro Utoh, Tomonori Miura, Yasuhiro Uno, Takahiro Hirano, Takashi Kusama, Marina Mitsui, Hiroshi Yamazaki, Makiko Shimizu, Mirai Kawano
Publikováno v:
Xenobiotica. 48:206-210
1. Cynomolgus monkey cytochrome P450 2C19 (formerly known as P450 2C75), homologous to human P450 2C19, has been identified as R-warfarin 7-hydroxylase. In this study, simulations of R-warfarin clearance in individual cynomolgus monkeys genotyped for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31d9c7f83c53ca01623b5fa4d63b828
https://doi.org/10.1080/00498254.2017.1288945
https://doi.org/10.1080/00498254.2017.1288945
Autor:
Makiko Shimizu, Hiroshi Yamazaki, Norio Shibata, Marina Mitsui, F. Peter Guengerich, Hiroshi Suemizu
Publikováno v:
Xenobiotica. 47:844-848
1. Pomalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species such as rabbits. Screening for thalidomide analogs devoid of teratogenicity/toxicity - attributable to metabolites formed by cytochrome P450 enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9bfd61935d03b1c1783fe472b4453e
https://doi.org/10.1080/00498254.2016.1247218
https://doi.org/10.1080/00498254.2016.1247218
Autor:
Shotaro Uehara, Erika Sasaki, Makiko Shimizu, Yasuhiro Uno, Mirai Kawano, Masahiro Utoh, Marina Mitsui, Akiko Toda, Hiroshi Suemizu, Hiroshi Yamazaki
Publikováno v:
Xenobiotica. 46:1049-1055
1. The pharmacokinetic data of cytochrome P450 probes in humans can be extrapolated from corresponding data in cynomolgus monkeys, dogs and minipigs using simplified physiologically based pharmacokinetic (PBPK) modeling. In this study, the modeling m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482dda9e01d989905e4afd0fac3e9a95
https://doi.org/10.3109/00498254.2016.1147102
https://doi.org/10.3109/00498254.2016.1147102
Autor:
Amit S. Kalgutkar, Shinichi Ninomiya, Satoshi Ito, Hidetaka Kamimura, Marina Mitsui, Sho Nishinoaki, Yosuke Yamamoto, Tomohiro Ishiguro, Hiroshi Yamazaki, Takeshi Okuzono, Hiroyuki Chijiwa, Hiroshi Suemizu
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(5)
1. The partial glucokinase activator N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide (PF-04937319) is biotransformed in humans to N-methyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7384c958a8a75c33de5f3f07a5e15e
https://pubmed.ncbi.nlm.nih.gov/27389028
https://pubmed.ncbi.nlm.nih.gov/27389028
Publikováno v:
Chemical research in toxicology. 29(12)
Species differences exist in terms of drug oxidation activities, which are mediated mainly by cytochrome P450 (P450) enzymes. To overcome the problem of species extrapolation, transchromosomic mice containing a human P450 3A cluster or chimeric mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e197dcf7f656b8f91b42d1aeef48fee
https://pubmed.ncbi.nlm.nih.gov/27337115
https://pubmed.ncbi.nlm.nih.gov/27337115
Publikováno v:
Chemical Research in Toxicology; Dec2016, Vol. 29 Issue 12, p1903-1911, 9p