Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Marina Mione"'
Autor:
Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio, Fabrizio d’Adda di Fagagna
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10–15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional t
Externí odkaz:
https://doaj.org/article/96aecb24e77f4ab3b16b729a382e090c
Autor:
Alex Pezzotta, Loredana Brioschi, Sabrina Carbone, Beatrice Mazzoleni, Vittorio Bontempi, Federica Monastra, Laura Mauri, Anna Marozzi, Marina Mione, Anna Pistocchi, Paola Viani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5771 (2023)
Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM negatively impact patients’ survival. Temozolomide (TMZ) is currently considered the first-choice
Externí odkaz:
https://doaj.org/article/446b70b9182844c491e5cedfb062ce6f
Autor:
Valentina Biagini, Federica Busi, Viviana Anelli, Emanuela Kerschbamer, Marta Baghini, Elena Gurrieri, Michela Notarangelo, Isabella Pesce, Guillaume van Niel, Vito G. D’Agostino, Marina Mione
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5510 (2022)
Extracellular vesicles (EVs) are membranous particles released by all cell types. Their role as functional carrier of bioactive molecules is boosted by cells that actively secrete them in biological fluids or in the intercellular space (interstitial
Externí odkaz:
https://doaj.org/article/4294b372421140d8817ccecf9852091f
Autor:
Indre Piragyte, Thomas Clapes, Aikaterini Polyzou, Ramon I. Klein Geltink, Stylianos Lefkopoulos, Na Yin, Pierre Cauchy, Jonathan D. Curtis, Lhéanna Klaeylé, Xavier Langa, Cora C. A. Beckmann, Marcin W. Wlodarski, Patrick Müller, Dominic Van Essen, Angelika Rambold, Friedrich G. Kapp, Marina Mione, Joerg M. Buescher, Erika L. Pearce, Alexander Polyzos, Eirini Trompouki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and hu
Externí odkaz:
https://doaj.org/article/6e1870de09fa401dacacea3d50a2697e
Autor:
Marie Mayrhofer, Victor Gourain, Markus Reischl, Pierre Affaticati, Arnim Jenett, Jean-Stephane Joly, Matteo Benelli, Francesca Demichelis, Pietro Luigi Poliani, Dirk Sieger, Marina Mione
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 1, Pp 15-28 (2017)
Somatic mutations activating MAPK and PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumours based on somatic expression of oncogenes that activate MAPK and PI3K signalli
Externí odkaz:
https://doaj.org/article/6ea228aad95c4f3bb6d9f799cee87c3c
Publikováno v:
eLife, Vol 7 (2018)
It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that macrophages a
Externí odkaz:
https://doaj.org/article/255d8380a6f1430295963321963effef
Autor:
Maria Solange Ibarra, Carla Borini Etichetti, Carolina Di Benedetto, Germán L Rosano, Ezequiel Margarit, Giannino Del Sal, Marina Mione, Javier Girardini
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175939 (2017)
The prolyl isomerase Pin1 plays a key role in the modulation of proline-directed phosphorylation signaling by inducing local conformational changes in phosphorylated protein substrates. Extensive studies showed different roles for Pin1 in physiologic
Externí odkaz:
https://doaj.org/article/5f6106546d0f46369ca0b530ccc3e8f7
Publikováno v:
PLoS Biology, Vol 14, Iss 2, p e1002377 (2016)
Externí odkaz:
https://doaj.org/article/3b194b148b5c46b6a2de2a929170310a
Autor:
Elisa Bernardi, Gianluca Deflorian, Federica Pezzinenti, Victor M. Diaz, Marina Mione, Francesco Blasi
Publikováno v:
PLoS ONE, Vol 6, Iss 4 (2011)
Externí odkaz:
https://doaj.org/article/7416d9152a6048489066ed388c71fff2
Publikováno v:
PLoS Biology, Vol 8, Iss 12, p e1000562 (2010)
It has not previously been possible to live image the earliest interactions between the host environment and oncogene-transformed cells as they initiate formation of cancers within an organism. Here we take advantage of the translucency of zebrafish
Externí odkaz:
https://doaj.org/article/bf6af1e0358442b3bb1f43a323351321