Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Marina Mikhaylova"'
Autor:
Kira V. Gromova, Edda Thies, Philipp C. Janiesch, Felix P. Lützenkirchen, Yipeng Zhu, Daniele Stajano, Céline D. Dürst, Michaela Schweizer, Anja Konietzny, Marina Mikhaylova, Christine E. Gee, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112743- (2023)
Summary: Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptor
Externí odkaz:
https://doaj.org/article/b4ea89a9a8004deeb934439ce397a69b
Autor:
Balaganesh Kuruba, Nickolas Starks, Mary Rose Josten, Ori Naveh, Gary Wayman, Marina Mikhaylova, Alla S. Kostyukova
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1237 (2023)
Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron. Remodeling of cytoskeletal
Externí odkaz:
https://doaj.org/article/562fe06c88d44f60a11f480173176e55
Autor:
Maximilian Borgmeyer, Cristina Coman, Canan Has, Hans-Frieder Schött, Tingting Li, Philipp Westhoff, Yam F.H. Cheung, Nils Hoffmann, PingAn Yuanxiang, Thomas Behnisch, Guilherme M. Gomes, Mael Dumenieu, Michaela Schweizer, Michaela Chocholoušková, Michal Holčapek, Marina Mikhaylova, Michael R. Kreutz, Robert Ahrends
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109797- (2021)
Summary: Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to prob
Externí odkaz:
https://doaj.org/article/598b45cadbbb4e3b8718c62af1798189
Autor:
Michael Bucher, Stephan Niebling, Yuhao Han, Dmitry Molodenskiy, Fatemeh Hassani Nia, Hans-Jürgen Kreienkamp, Dmitri Svergun, Eunjoon Kim, Alla S Kostyukova, Michael R Kreutz, Marina Mikhaylova
Publikováno v:
eLife, Vol 10 (2021)
Members of the SH3- and ankyrin repeat (SHANK) protein family are considered as master scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations within the canonical SHANK3 isoform have been proposed as causative for
Externí odkaz:
https://doaj.org/article/ae5e4335b9ee493d9711cd6022768961
Autor:
Eugene A. Katrukha, Marina Mikhaylova, Hugo X. van Brakel, Paul M. van Bergen en Henegouwen, Anna Akhmanova, Casper C. Hoogenraad, Lukas C. Kapitein
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Methods to probe transport dynamics within cells can shed insight into the nature of the cytoplasm. Here the authors develop a method to functionalize and deliver quantum dots intracellularly to show how the cytoskeleton influences non-equilibrium in
Externí odkaz:
https://doaj.org/article/a471b41a01894b80a775b59d0e03eae6
Autor:
Christian K. Frese, Marina Mikhaylova, Riccardo Stucchi, Violette Gautier, Qingyang Liu, Shabaz Mohammed, Albert J.R. Heck, A.F. Maarten Altelaar, Casper C. Hoogenraad
Publikováno v:
Cell Reports, Vol 18, Iss 6, Pp 1527-1542 (2017)
Neuronal differentiation is a multistep process that shapes and re-shapes neurons by progressing through several typical stages, including axon outgrowth, dendritogenesis, and synapse formation. To systematically profile proteome dynamics throughout
Externí odkaz:
https://doaj.org/article/383785ce8f5c4633a29a7d4892c4c565
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 189-199 (2016)
The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local sy
Externí odkaz:
https://doaj.org/article/965cd72e781647bab5bb81d26510338d
Publikováno v:
Cells, Vol 9, Iss 9, p 2006 (2020)
Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible ro
Externí odkaz:
https://doaj.org/article/3418d73a9eb543bfb0e0fe3b8c3e32a4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the establishment and the maintenance of neuronal polarity. For a long time, the most prominent roles that were attributed to actin in neurons were the movement
Externí odkaz:
https://doaj.org/article/16bb8e1f294f4246b8a3ddb0d0f6e14d
Autor:
Christina Spilker, Sven Nullmeier, Katarzyna M Grochowska, Anne Schumacher, Ioana Butnaru, Tamar Macharadze, Guilherme M Gomes, PingAn Yuanxiang, Gonca Bayraktar, Carolin Rodenstein, Carolin Geiseler, Angela Kolodziej, Jeffrey Lopez-Rojas, Dirk Montag, Frank Angenstein, Julia Bär, Wolfgang D'Hanis, Thomas Roskoden, Marina Mikhaylova, Eike Budinger, Frank W Ohl, Oliver Stork, Ana C Zenclussen, Anna Karpova, Herbert Schwegler, Michael R Kreutz
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005907 (2016)
Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (
Externí odkaz:
https://doaj.org/article/be102f6df7474cccbf12c201592fe231