Výsledky vyhledávání - "Marina M, Mourão"

Akademický článek

Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK

Autor: Bernardo P. Moreira, Sandra G. Gava, Simone Haeberlein, Sophie Gueye, Ester S. S. Santos, Michael H. W. Weber, Tigran M. Abramyan, Christoph G. Grevelding, Marina M. Mourão, Franco H. Falcone

Publikováno v: Frontiers in Parasitology, Vol 3 (2024)

IntroductionSchistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs ar

Externí odkaz: https://doaj.org/article/080be4b1e91b4e59a075ffc81f851067

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Akademický článek

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

Autor: Martina Maccesi, Pedro H. N. Aguiar, Valérian Pasche, Melody Padilla, Brian M. Suzuki, Sandro Montefusco, Ruben Abagyan, Jennifer Keiser, Marina M. Mourão, Conor R. Caffrey

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Background Over the past five years, as a public service to encourage and accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasi

Externí odkaz: https://doaj.org/article/409ebe9371c34ff0b5f701fa37ac4641

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Akademický článek

Gene Expression Signatures in AML-12 Hepatocyte Cells upon Dengue virus Infection and Acetaminophen Treatment

Autor: Jorge G. G. Ferreira, Sandra G. Gava, Eneida S. Oliveira, Izabella C. A. Batista, Gabriel da R. Fernandes, Marina M. Mourão, Carlos E. Calzavara-Silva

Publikováno v: Viruses, Vol 12, Iss 11, p 1284 (2020)

Dengue is an acute viral disease caused by Dengue virus (DENV) and is considered to be the most common arbovirus worldwide. The clinical characteristics of dengue may vary from asymptomatic to severe complications and severe organ impairment, particu

Externí odkaz: https://doaj.org/article/c1b00de8197e48d7ae236190123d2265

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Akademický článek

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

Autor: Letícia Anderson, Monete Rajão Gomes, Lucas Ferreira daSilva, Adriana da Silva Andrade Pereira, Marina M Mourão, Christophe Romier, Raymond Pierce, Sergio Verjovski-Almeida

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005539 (2017)

BACKGROUND:Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as

Externí odkaz: https://doaj.org/article/2b0ac833577647d8aded8ea98023a28e

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Effects of Structurally Different HDAC Inhibitors against

Autor: Elisabetta, Di Bello, Beatrice, Noce, Rossella, Fioravanti, Clemens, Zwergel, Sergio, Valente, Dante, Rotili, Giulia, Fianco, Daniela, Trisciuoglio, Marina M, Mourão, Policarpo, Sales, Suzanne, Lamotte, Eric, Prina, Gerald F, Späth, Cécile, Häberli, Jennifer, Keiser, Antonello, Mai

Publikováno v: ACS infectious diseases. 8(7)

Neglected tropical diseases (NTDs), including trypanosomiasis, leishmaniasis, and schistosomiasis, result in a significant burden in terms of morbidity and mortality worldwide every year. Current antiparasitic drugs suffer from several limitations su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c138179b88dce37a07a1b09504bfc8e
https://pubmed.ncbi.nlm.nih.gov/35732073

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Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni

Autor: Elisabetta Di Bello, Beatrice Noce, Rossella Fioravanti, Clemens Zwergel, Sergio Valente, Dante Rotili, Giulia Fianco, Daniela Trisciuoglio, Marina M. Mourão, Policarpo Sales, Suzanne Lamotte, Eric Prina, Gerald F. Späth, Cécile Häberli, Jennifer Keiser, Antonello Mai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9849e23039483f21b1806ea90ad9cb74
http://hdl.handle.net/11573/1650772

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Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 37, ⟨10.1016/j.celrep.2021.110129⟩

Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries, thus, represents a valid approach to fighting parasitic diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ace4f324f4075f85756d3020e718daf
https://pubmed.ncbi.nlm.nih.gov/34936867

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Akademický článek

New Frontiers in Schistosoma Genomics and Transcriptomics

Autor: Laila A. Nahum, Marina M. Mourão, Guilherme Oliveira

Publikováno v: Journal of Parasitology Research, Vol 2012 (2012)

Schistosomes are digenean blood flukes of aves and mammals comprising 23 species. Some species are causative agents of human schistosomiasis, the second major neglected disease affecting over 230 million people worldwide. Modern technologies includin

Externí odkaz: https://doaj.org/article/cbba2d7389724682839d9b9c70498512

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Akademický článek

Molecular characterization of the Schistosoma mansoni zinc finger protein SmZF1 as a transcription factor.

Autor: Marcela G Drummond, Carlos E Calzavara-Silva, Diego S D'Astolfo, Fernanda C Cardoso, Matheus A Rajão, Marina M Mourão, Elisandra Gava, Sérgio C Oliveira, Andréa M Macedo, Carlos R Machado, Sérgio D J Pena, Gregory T Kitten, Glória R Franco

Publikováno v: PLoS Neglected Tropical Diseases, Vol 3, Iss 11, p e547 (2009)

BACKGROUND: During its development, the parasite Schistosoma mansoni is exposed to different environments and undergoes many morphological and physiological transformations as a result of profound changes in gene expression. Characterization of prote

Externí odkaz: https://doaj.org/article/8cc3acc5733d489abdbabc3ddf308149

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Identification of the bacterial community responsible for traditional fermentation during sour cassava starch, cachaça and minas cheese production using culture-independent 16s rRNA gene sequence analysis

Autor: Inayara C. A. Lacerda, Fátima C. O. Gomes, Beatriz M. Borelli, César L. L. Faria Jr, Gloria R. Franco, Marina M. Mourão, Paula B. Morais, Carlos A. Rosa

Publikováno v: Brazilian Journal of Microbiology, Volume: 42, Issue: 2, Pages: 650-657, Published: JUN 2011
Publons
Brazilian Journal of Microbiology, Vol 42, Iss 2, Pp 650-657 (2011)
Brazilian Journal of Microbiology v.42 n.2 2011
Brazilian Journal of Microbiology
Sociedade Brasileira de Microbiologia (SBM)
instacron:SBM

We used a cultivation-independent, clone library-based 16S rRNA gene sequence analysis to identify bacterial communities present during traditional fermentation in sour cassava starch, cachaça and cheese production in Brazil. Partial 16S rRNA gene c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9b8941151f4a3f77979e09f480fa61
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000200029&lng=en&tlng=en

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