Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Marina Lucie Louise Cools"'
Autor:
Erwin Coesemans, Marina Lucie Louise Cools, Guy Van Lommen, Mieke Buntinx, Bart Hermans, Jean VanWauwe, Julien Doyon, Staf Boeckx
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:497-500
We describe the synthesis and SAR of a new class of CCR2 antagonists based on 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC(50) values in the MCP-1 induced Ca-flux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b821dd173f3470d6fb64ea02242992a
https://doi.org/10.1016/j.bmcl.2004.11.064
https://doi.org/10.1016/j.bmcl.2004.11.064
Autor:
Didier de Chaffoy, Gustaaf Maria Boeckx, Gaston Stanislas Marcella Diels, Pedro Pardal Martínez, Davy Petrus Franciscus Maria Petit, Jean Pierre Frans Van Wauwe, Fred De Clerck, Marina Lucie Louise Cools, Anton Megens, José Manuel Alonso, Javier Fernández, Danielle Peeters, Adolfo Dı́az, Paul Stoppie, Laura Iturrino, Marijke Somers, F. Deroose, J. Ignacio Andres, Eddy Jean Edgard Freyne, Encarna Matesanz
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370d2b7a16379bfe3918f2b9bb162f31
https://pubmed.ncbi.nlm.nih.gov/11844693
https://pubmed.ncbi.nlm.nih.gov/11844693
Publikováno v:
International journal of immunopharmacology. 14(6)
The antifungal drugs ketoconazole and itraconazole were evaluated for their effects in the following test systems: in vitro, phytohaemagglutinin (PHA)-induced proliferation of human peripheral blood mononuclear cells and IL-2-driven proliferation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a038474d198f81c04e3efec85ef13f95
https://pubmed.ncbi.nlm.nih.gov/1330944
https://pubmed.ncbi.nlm.nih.gov/1330944