Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marina Kuchuk"'
Autor:
Charles A. Maitz, Samantha Delaney, Brendon E. Cook, Afaf R. Genady, Rebecca Hoerres, Marina Kuchuk, Georgios Makris, John F. Valliant, Saman Sadeghi, Jason S. Lewis, Heather M. Hennkens, Jeffrey N. Bryan, Brian M. Zeglis
Publikováno v:
Mol Pharm
The last decade has played witness to the creation of a highly effective approach to in vivo pretargeting based on the inverse electron demand Diels-Alder (IEDDA) click ligation between tetrazine (Tz) and trans-cyclooctene (TCO). Despite the steady p
Autor:
Jing Wang, George Makris, Lauren Radford, Silvia S. Jurisson, Heather M. Hennkens, Fabio Gallazzi, Michael R. Lewis, Marina Kuchuk
Publikováno v:
Nuclear Medicine and Biology. :46-52
Introduction With the long-term goal of developing a diagnostic (99mTc) and therapeutic (186Re) agent pair for targeting somatostatin receptor (SSTR)-positive neuroendocrine tumors (NETs), we developed novel metal-cyclized peptides through direct lab
Autor:
Heather M. Hennkens, Rajendra P. Bandari, Antonio Shegani, Pavithra H.A. Kankanamalage, Marina Kuchuk, George Makris, Charles J. Smith
Publikováno v:
Bioconjugate Chemistry. 32:1290-1297
We report herein the preclinical evaluation of new [64Cu]Cu-gastrin-releasing peptide receptor (GRPR)-targeting tracers, employing the potent peptide antagonist DPhe-Gln-Trp-Ala-VaI-Gly-His-Sta-Leu-NH2 conjugated to NOTA (in 1) or NODAGA (in 2) chela
Autor:
Heather M. Hennkens, Rajendra P. Bandari, Silvia S. Jurisson, Marina Kuchuk, George Makris, Charles J. Smith
Publikováno v:
Molecular Imaging and Biology. 23:52-61
The goal of this work was to develop hydrophilic gastrin-releasing peptide receptor (GRPR)-targeting complexes of the general formula fac-[M(CO)3(L)]+ [M = natRe, 99mTc, 186Re; L: NOTA for 1, NODAGA for 2] conjugated to a powerful GRPR peptide antago
Autor:
Aisyah Faruk, Anush Nersesyan, Astghik Papikyan, Sona Galstyan, Emma Hakobyan, Tinatin Barblishvili, Tsira Mikatadze‐Pantsulaia, Tamaz Darchidze, Marina Kuchukhidze, Nona Kereselidze, David Kikodze, Ian Willey, Philippa Ryan, Elinor Breman
Publikováno v:
Plants, People, Planet, Vol 6, Iss 1, Pp 238-248 (2024)
Societal Impact Statement Ecosystem services are underpinned by biodiversity, which is rapidly eroding globally, threatening rural livelihoods and culture. Examining the uses of wild edible plants (WEPs) that are important to rural communities gives
Externí odkaz:
https://doaj.org/article/a713e27c7a3e4ec8b528f76e5be230d5
Autor:
Marina Kuchuk, Silvia S. Jurisson, Fabio Gallazzi, Heather M. Hennkens, Charles J. Smith, George Makris
Publikováno v:
Nuclear Medicine and Biology. 71:39-46
Introduction The aim of this work was to develop diagnostic (99mTc) and therapeutic (186Re) agents for targeting somatostatin receptor (SSTR)-positive neuroendocrine tumors (NETs). In this regard, we evaluated in vitro complexes of the general formul
Autor:
Charles J. Smith, Fabio Gallazzi, Silvia S. Jurisson, Marina Kuchuk, George Makris, Heather M. Hennkens, Lauren Radford
Publikováno v:
Bioconjugate Chemistry. 29:4040-4049
With the long-term goal of developing theranostic agents for applications in nuclear medicine, in this work we evaluated the well-known NOTA and NODAGA chelators as bifunctional chelators (BFCs) for the [99mTc/186Re]Tc/Re-tricarbonyl core. In particu
Autor:
George, Makris, Antonio, Shegani, Pavithra H A, Kankanamalage, Marina, Kuchuk, Rajendra P, Bandari, Charles J, Smith, Heather M, Hennkens
Publikováno v:
Bioconjugate chemistry. 32(7)
We report herein the preclinical evaluation of new [
Autor:
Jing, Wang, George, Makris, Marina, Kuchuk, Lauren, Radford, Fabio, Gallazzi, Michael R, Lewis, Silvia S, Jurisson, Heather M, Hennkens
Publikováno v:
Nuclear medicine and biology.
With the long-term goal of developing a diagnostic (Re-1 was characterized by LC-ESI-MS and HR-ESI-MS and was tested for receptor affinity in SSTR-expressing cells (AR42J). Radiolabeling of the peptide was achieved via ligand exchange fromRe-1 consis
Autor:
George, Makris, Rajendra P, Bandari, Marina, Kuchuk, Silvia S, Jurisson, Charles J, Smith, Heather M, Hennkens
Publikováno v:
Molecular imaging and biology. 23(1)
The goal of this work was to develop hydrophilic gastrin-releasing peptide receptor (GRPR)-targeting complexes of the general formula fac-[M(CO)Metallated-peptides were prepared employing the [M(OHHigh in vitro receptor affinity (IC[