Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Marina Kleanthous"'
Autor:
Basma Naiisseh, Panayiota L. Papasavva, Nikoletta Y. Papaioannou, Marios Tomazou, Lola Koniali, Xenia Felekis, Constantina G. Constantinou, Maria Sitarou, Soteroula Christou, Marina Kleanthous, Carsten W. Lederer, Petros Patsali
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102183- (2024)
β-Thalassemia is brought about by defective β-globin (HBB [hemoglobin subunit β]) formation and, in severe cases, requires regular blood transfusion and iron chelation for survival. Genome editing of hematopoietic stem cells allows correction of u
Externí odkaz:
https://doaj.org/article/b91282ff2bb6418eb5eea22e8d27f4eb
Autor:
Coralea Stephanou, Miranda Petrou, Petros Kountouris, Christiana Makariou, Soteroula Christou, Michael Hadjigavriel, Marina Kleanthous, Thessalia Papasavva
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 296 (2024)
The +33 C>G variant [NM_000518.5(HBB):c.-18C>G] in the 5′ untranslated region (UTR) of the β-globin gene is described in the literature as both mild and silent, while it causes a phenotype of thalassemia intermedia in the presence of a severe β-t
Externí odkaz:
https://doaj.org/article/602ef8c19edc49abad13e789fc66f16f
Autor:
Lola Koniali, Christina Flouri, Markela I. Kostopoulou, Nikoletta Y. Papaioannou, Panayiota L. Papasavva, Basma Naiisseh, Coralea Stephanou, Anthi Demetriadou, Maria Sitarou, Soteroula Christou, Michael N. Antoniou, Marina Kleanthous, Petros Patsali, Carsten W. Lederer
Publikováno v:
Cells, Vol 12, Iss 24, p 2848 (2023)
Therapy via the gene addition of the anti-sickling βAS3-globin transgene is potentially curative for all β-hemoglobinopathies and therefore of particular clinical and commercial interest. This study investigates GLOBE-based lentiviral vectors (LVs)
Externí odkaz:
https://doaj.org/article/ced4c48ca6ed44b9a025e89953ea0fe4
Autor:
José Martín Solórzano González, Sara Isabel Reidel, Ines Labidi, Claire Diot Lefebvre, Stella Tamana, Victoria Gutierrez Valle, Eduard van Beers, Raffaella Colombatti, Paola Bianchi, Angelo Loris Brunetta, Dore Peereboom, Frédéric Galactéros, Giovanna Russo, Antonis Kattamis, Laurence Dedeken, Joachim Kunz, Elena Cela, Celeste Bento, Ulf Tedgard, Andreas Glenthøj, Soteroula Christou, Marina Kleanthous, Petros Kountouris, Beatrice Gulbis, Maria Del Mar Mañú Pereira
Publikováno v:
HemaSphere, Vol 7, p e13208ab (2023)
Externí odkaz:
https://doaj.org/article/dda4d76b94d94600b11ff5e166a87910
Autor:
Petros Kountouris, Coralea Stephanou, Maxwell Nwegbu, Obiageli Nnodu, Morohuntodun Oni, Natasha Archer, Leon Tshilolo, Bin Alwi Zilfalil, Kyriaki Michailidou, Viviana Giannuzzi, Fedele Bonifazi, Marina Kleanthous
Publikováno v:
HemaSphere, Vol 7, p e22097c3 (2023)
Externí odkaz:
https://doaj.org/article/72fe500010074d889b99ecfca556b470
Autor:
Maria Xenophontos, Anna Minaidou, Coralea Stephanou, Stella Tamana, Marina Kleanthous, Petros Kountouris
Publikováno v:
HemaSphere, Vol 7, Iss 7, p e922 (2023)
Externí odkaz:
https://doaj.org/article/9622015736184bd8893784b123aeb29f
Autor:
Stefania Byrou, George Christopoulos, Agathoklis Christofides, Christiana Makariou, Christiana Ioannou, Marina Kleanthous, Thessalia Papasavva
Publikováno v:
Thalassemia Reports, Vol 12, Iss 3, Pp 55-72 (2022)
The assignment of alleles to haplotypes in prenatal diagnostic assays has traditionally depended on family study analyses. However, this prevents the wide application of prenatal diagnosis based on haplotype analysis, especially in countries with dis
Externí odkaz:
https://doaj.org/article/37e765c92ede425494f5ae533a04228f
Autor:
Nikoletta Y. Papaioannou, Petros Patsali, Basma Naiisseh, Panayiota L. Papasavva, Lola Koniali, Ryo Kurita, Yukio Nakamura, Soteroula Christou, Maria Sitarou, Claudio Mussolino, Toni Cathomen, Marina Kleanthous, Carsten W. Lederer
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Introduction: Genome editing tools, such as CRISPR/Cas, TALE nucleases and, more recently, double-strand-break-independent editors, have been successfully used for gene therapy and reverse genetics. Among various challenges in the field, tolerable an
Externí odkaz:
https://doaj.org/article/0fbfbdfb3fde4f0eb2824e45f9241f24
Autor:
Anna Collado, Maria Paola Boaro, Sigrid van der Veen, Amira Idrizovic, Bart J. Biemond, David Beneitez Pastor, Ana Ortuño, Elena Cela, Anna Ruiz-Llobet, Pablo Bartolucci, Marianne de Montalembert, Gastone Castellani, Riccardo Biondi, Renzo Manara, Tiziana Sanavia, Piero Fariselli, Petros Kountouris, Marina Kleanthous, Federico Alvarez, Santiago Zazo, Raffaella Colombatti, Eduard J. van Beers, María del Mar Mañú-Pereira
Publikováno v:
HemaSphere, Vol 7, Iss 3, p e844 (2023)
Externí odkaz:
https://doaj.org/article/530e1091e12141999d0341769ca491eb
Autor:
Stella Tamana, Maria Xenophontos, Anna Minaidou, Coralea Stephanou, Cornelis L Harteveld, Celeste Bento, Joanne Traeger-Synodinos, Irene Fylaktou, Norafiza Mohd Yasin, Faidatul Syazlin Abdul Hamid, Ezalia Esa, Hashim Halim-Fikri, Bin Alwi Zilfalil, Andrea C Kakouri, ClinGen Hemoglobinopathy Variant Curation Expert Panel, Marina Kleanthous, Petros Kountouris
Publikováno v:
eLife, Vol 11 (2022)
Haemoglobinopathies are the commonest monogenic diseases worldwide and are caused by variants in the globin gene clusters. With over 2400 variants detected to date, their interpretation using the American College of Medical Genetics and Genomics (ACM
Externí odkaz:
https://doaj.org/article/685e2a791891446ba71327c90bbdab61