Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marina Ignatushchenko"'
Autor:
Pär Nordlund, Chen Dan, Daniel Martinez Molina, Marina Ignatushchenko, Yihai Cao, Lekshmy Sreekumar, Takahiro Seki, Rozbeh Jafari, E. Andreas Larsson
Publikováno v:
Science. 341:84-87
Drug Targeting Drug efficacy depends on the extent of binding to a cellular target (often a protein) with adverse effects caused by excessive target binding or by off-target binding. Engagement of a target protein inside cells is influenced by the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d563eee3ab63be84bb2e6eef2b5ef3
https://doi.org/10.1126/science.1233606
https://doi.org/10.1126/science.1233606
Autor:
Said Eshaghi, Daniel Martinez Molina, Tobias Cornvik, Jesper Z. Haeggström, Marina Ignatushchenko Sabet, Pär Nordlund
Publikováno v:
Protein Science. 17:673-680
Membrane proteins play a fundamental role in human disease and therapy, but suffer from a lack of structural and functional information compared to their soluble counterparts. The paucity of membrane protein structures is primarily due to the unparal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d52db56516d5148f163d8d13a4ae52
https://doi.org/10.1110/ps.073242508
https://doi.org/10.1110/ps.073242508
Autor:
Said Eshaghi, Marina Ignatushchenko Abdel Nasser, Tove Hammarberg, Marie Hedrén, Anders Thornell, Pär Nordlund
Publikováno v:
Protein Science. 14:676-683
The recombinant expression of integral membrane proteins is considered a major challenge, and together with the crystallization step, the major hurdle toward routine structure determination of membrane proteins. Basic methodologies for high-throughpu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d11fc7750a8ca7e01409b30a258853
https://doi.org/10.1110/ps.041127005
https://doi.org/10.1110/ps.041127005
Autor:
Thomas Lundbäck, Pär Nordlund, Marina Ignatushchenko, Rozbeh Jafari, Hanna Axelsson, Daniel Martinez Molina, Helena Almqvist
Publikováno v:
Nature protocols. 9(9)
Thermal shift assays are used to study thermal stabilization of proteins upon ligand binding. Such assays have been used extensively on purified proteins in the drug discovery industry and in academia to detect interactions. Recently, we published a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53d155ebf98b2230921ab70954ff259
https://pubmed.ncbi.nlm.nih.gov/25101824
https://pubmed.ncbi.nlm.nih.gov/25101824
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 62:77-81
The erythrocytic development of Plasmodium falciparum is divided into the ring, trophozoite, and schizont stages based on morphologic assessment. Using highly synchronous ring and trophozoite cultures of P. falciparum, we observed considerable differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362742d06e4e9635e69c29be33e7a4e2
https://doi.org/10.4269/ajtmh.2000.62.77
https://doi.org/10.4269/ajtmh.2000.62.77
Autor:
Marina Ignatushchenko, David J. Hinrichs, Ayoade M.J. Oduola, Olumide A. T. Ogundahunsi, Rolf W. Winter, Michael K. Riscoe, Kenneth A. Cornell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:1449-1454
In a previous report we described the synergistic antimalarial interaction between two structurally similar compounds, rufigallol and exifone. To explain this phenomenon, we proposed that exifone is transformed inside the parasitized erythrocyte into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50718ebb2a04873c55bcbad9f5c6d086
https://doi.org/10.1128/aac.41.7.1449
https://doi.org/10.1128/aac.41.7.1449
Autor:
Marina Ignatushchenko, David J. Hinrichs, Linda L. Johnson, Kenneth A. Cornell, Rolf W. Winter, Michael K. Riscoe
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:1408-1411
We have discovered a remarkable synergistic antimalarial interaction between rufigallol and the structurally similar compound exifone. The synergistic effects were produced in chloroquine-susceptible and chloroquine-resistant clones of Plasmodium fal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bc5556e82c002359ba09e9d0771abb
https://doi.org/10.1128/aac.40.6.1408
https://doi.org/10.1128/aac.40.6.1408
Publikováno v:
Microbial Cell Factories, Vol 10, Iss 1, p 35 (2011)
Microbial Cell Factories
Microbial Cell Factories
Background The production of integral membrane spanning proteins (IMP's) constitutes a bottleneck in pharmaceutical development. It was long considered that the state-of-the-art was to produce the proteins as inclusion bodies using a powerful inducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61039cbf6f0ee5ac864e659977d3d1d
http://www.microbialcellfactories.com/content/10/1/35
http://www.microbialcellfactories.com/content/10/1/35
Publikováno v:
Molecular and biochemical parasitology. 135(1)
Previous studies have established that the ISO1 glucose transporter of Leishmania enriettii resides primarily in the flagellar membrane, whereas the ISO2 glucose transporter is located in the pellicular plasma membrane surrounding the cell body. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15698b3e92702873ba6c0255ea26050b
https://pubmed.ncbi.nlm.nih.gov/15287590
https://pubmed.ncbi.nlm.nih.gov/15287590
Autor:
Marina Ignatushchenko, Jane Xu Kelly, David J. Hinrichs, Rolf W. Winter, Michael K. Riscoe, H. G. A. Bouwer, David H. Peyton
Publikováno v:
Molecular and biochemical parasitology. 126(1)
A rational approach in the search for new antiparasitic drugs is the exploitation of biochemical differences between the parasite and its mammalian host. One specific example in the case of Leishmania relates to the biosynthesis of heme, a critical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c17fac911e0f06d633ecbdef24850ae
https://pubmed.ncbi.nlm.nih.gov/12554083
https://pubmed.ncbi.nlm.nih.gov/12554083