Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter

Autor: Bernard Evers, Inge A. M. de Graaf, Ivan Vokral, Ming Li, Marina H. de Jager, Geny M. M. Groothuis

Publikováno v: European Journal of Pharmaceutical Sciences, 121, 65-73. ELSEVIER SCIENCE BV

The apical sodium-dependent bile acid transporter (ASBT) is the primary transporter for the uptake of bile acids in the small intestine. It is localized on the apical membrane of the ileal enterocytes and is known for its high capacity and affinity f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e0bb8e654e662d7cbcbc4d10dd5aab
https://doi.org/10.1016/j.ejps.2018.05.005

LSC-2019-Dysfunctional macrophage polarization in murine COPD exacerbation

Autor: Eduard Post, Corry-Anke Brandsma, René Lutter, Barbro N. Melgert, Linsey E. S. de Groot, Ken R. Bracke, Irene H. Heijink, Maarten van den Berge, T. Anienke van der Veen, Mirjam P. Roffel, Tania Maes, Marina H. de Jager, Ilse M. Boudewijn

Publikováno v: European Respiratory Journal, 54. EUROPEAN RESPIRATORY SOC JOURNALS LTD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ba936d3255170c3e2e0fd347a4ba4b
https://hdl.handle.net/11370/26eaf657-4dbe-4dd2-8fa9-821737eb444f

P-gp activity and inhibition in the different regions of human intestineex vivo

Autor: Marina H. de Jager, Geny M. M. Groothuis, Ming Li, Inge A. M. de Graaf

Publikováno v: Biopharmaceutics & Drug Disposition. 38:127-138

Although intestinal P-glycoprotein (P-gp) has been extensively studied in vitro and in animals, its activity and the consequences of P-gp inhibition for drug disposition and toxicity in humans are still difficult to accurately extrapolate from these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18efaa3c1962794729067158e1afe87
https://doi.org/10.1002/bdd.2047

Regional Differences in Human Intestinal Drug Metabolism

Autor: Marina H de Jager, Raditya Iswandana, Marina Ika Irianti, H. S. Hofker, Dorenda Oosterhuis, Marjolijn T Merema, Henricus Am Mutsaers, Peter Olinga

Publikováno v: Iswandana, R, Irianti, M I, Oosterhuis, D, Hofker, H S, Merema, M T, de Jager, M H, Mutsaers, H A M & Olinga, P 2018, ' Regional Differences in Human Intestinal Drug Metabolism ', Drug Metabolism and Disposition, vol. 46, no. 12, pp. 1879-1885 . https://doi.org/10.1124/dmd.118.083428

The intestines are key for the absorption of nutrients and water as well as drug metabolism, and it is well known that there are clear differences in the expression profile of drug metabolism enzymes along the intestinal tract. Yet only a few studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aaf07ead619a0e6477dd81e7cc0bcf
https://pubmed.ncbi.nlm.nih.gov/30275119

Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties

Autor: Angela Casini, Pierre Le Gendre, Michel Picquet, Ewen Bodio, Elena Warmerdam, Marina H. de Jager, David Monchaud, Marc Pirrotta, Geny M. M. Groothuis, Loic Stefan, Philippe Richard, Benoît Bertrand

Publikováno v: Inorganic Chemistry
Inorganic Chemistry, American Chemical Society, 2014, 53 (4), pp.2296-2303. ⟨10.1021/ic403011h⟩
Inorganic Chemistry, 53(4), 2296-2303. AMER CHEMICAL SOC

A new series of gold(I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands have been synthesized and characterized by mass spectrometry, NMR, and X-ray diffraction. The compounds have been tested for their antiproliferative properties i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254c90e09ce2d2d7d20284bcd2535bf4
https://doi.org/10.1021/ic403011h