Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Marina Guillén"'
Autor:
Marina Guillén-Yunta, Ángel García-Aldea, Víctor Valcárcel-Hernández, Ainara Sanz-Bógalo, Emma Muñoz-Moreno, Maria Gisele Matheus, Carmen Grijota-Martínez, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz, Soledad Bárez-López
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106621- (2024)
Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked disorder that causes severe neurological damage, for which there is no effective treatment. AHDS is due to inactivating mutations in the thyroid hormone transporter MCT8 that impair the entry of
Externí odkaz:
https://doaj.org/article/00765c84013245a289fc2b187923a54b
Autor:
Ángel García-Aldea, Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz, Soledad Bárez-López
Publikováno v:
European Thyroid Journal, Vol 13, Iss 2, Pp 1-9 (2024)
Thyroid hormones play an important role during the development and functioning of the different sensory systems. In order to exert their actions, thyroid hormones need to access their target cells through transmembrane transporter proteins, among whi
Externí odkaz:
https://doaj.org/article/930b764a158e4966b968db305a3dbaad
Autor:
Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ángel García-Aldea, Guadalupe Soria, José Manuel García-Verdugo, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background The monocarboxylate transporter 8 (MCT8) plays a vital role in maintaining brain thyroid hormone homeostasis. This transmembrane transporter is expressed at the brain barriers, as the blood–brain barrier (BBB), and in neural cel
Externí odkaz:
https://doaj.org/article/0eeb6dae8d194ee1ad7e04172c78f784
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S119- (2023)
Externí odkaz:
https://doaj.org/article/645e4beb96314ae49d96f3ecbd2595a7
Autor:
Mario Benito, Ramón Román, Garazi Ortiz, Antoni Casablancas, Gregorio Álvaro, Gloria Caminal, Gloria González, Marina Guillén
Publikováno v:
Journal of Biological Engineering, Vol 16, Iss 1, Pp 1-14 (2022)
Abstract Background The feasibility of biochemical transformation processes is usually greatly dependent on biocatalysts cost. Therefore, immobilizing and reusing biocatalysts is an approach to be considered to bring biotransformations closer to indu
Externí odkaz:
https://doaj.org/article/765307951d4346459cb356d74d9866c9
Autor:
Víctor Valcárcel-Hernández, Marina Guillén-Yunta, Miranda Bueno-Arribas, Ana Montero-Pedrazuela, Carmen Grijota-Martínez, Suzy Markossian, Ángel García-Aldea, Frédéric Flamant, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105896- (2022)
Inactivating mutations in the specific thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to an X-linked rare disease named MCT8 deficiency or Allan-Herndon-Dudley Syndrome. Patients exhibit a plethora of severe endocrine and neuro
Externí odkaz:
https://doaj.org/article/272bf65832e14e22823ca721de1521f1
Autor:
Víctor Valcárcel-Hernández, Daniela López-Espíndola, Marina Guillén-Yunta, Ángel García-Aldea, Inés López de Toledo Soler, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105567- (2022)
Mutations in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to profound brain alterations, including myelination impairments, in humans. We aimed to further explore the pathophysiological mechanisms underlying the MCT8 defi
Externí odkaz:
https://doaj.org/article/589a1f6799c14691a43c1635754f92f2
Autor:
Gerard Masdeu, Luis Miguel Vázquez, Josep López-Santín, Gloria Caminal, Slavko Kralj, Darko Makovec, Gregorio Álvaro, Marina Guillén
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250513 (2021)
Fructose-6-phosphate aldolase (FSA) is an important enzyme for the C-C bond-forming reactions in organic synthesis. The present work is focused on the synthesis of a precursor of D-fagomine catalyzed by a mutant FSA. The biocatalyst has been immobili
Externí odkaz:
https://doaj.org/article/ffa798783eb746f1919d8f01139988a6
Publikováno v:
Catalysts, Vol 11, Iss 8, p 973 (2021)
Asymmetric synthesis of chiral amines from prochiral ketones using transaminases is an attractive biocatalytic strategy. Nevertheless, it is hampered by its unfavorable thermodynamic equilibrium. In the present work, an insitu by-product removal stra
Externí odkaz:
https://doaj.org/article/8ea3c22d9d664715b07f7bb0858d729c
Autor:
Víctor Valcárcel-Hernández, Marina Guillén-Yunta, Thomas S. Scanlan, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Thyroid. 33:632-640
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2243a5353100ffe8402984b1ee084f5e
https://doi.org/10.1089/thy.2022.0612
https://doi.org/10.1089/thy.2022.0612