Výsledky vyhledávání - "Marina G.D. Leed"

Synthesis and Physicochemical Characterization of a Diethyl Ester Prodrug of DTPA and Its Investigation as an Oral Decorporation Agent in Rats

Autor: James E. Huckle, Matthew P. Sadgrove, Yu Tsai Yang, Michael Jay, Richard C. Semelka, Russell J. Mumper, Marina G.D. Leed

Publikováno v: The AAPS Journal. 18:972-980

The increasing threats of nuclear terrorism have made the development of medical countermeasures a priority for international security. Injectable formulations of diethylenetriaminepentaacetic acid (DTPA) have been approved by the FDA; however, an or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2edfd60f75d0b0bbf8dc009da2f7b63
https://doi.org/10.1208/s12248-016-9916-z

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Interspecies Differences in the Metabolism of a Multi-Ester Prodrug by Carboxylesterases

Autor: Michael Jay, Lesley Marson, Jing Fu, Marina G.D. Leed, Matthew P. Sadgrove, Erik Pacyniak

The pentaethyl ester prodrug of the chelating agent diethylene triamine pentaacetic acid (DTPA) referred to as C2E5 is being developed as an orally bioavailable radionuclide decorporation agent. The predicted human efficacy obtained in these experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dd0050c8ef2a2747526fa91798e05a
https://europepmc.org/articles/PMC4781669/

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Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: Assessment of safety and efficacy in an inhalation-contamination model

Autor: Russell J. Mumper, Robert L. Susick, Michael Jay, Bushra J. Agha, Erik Pacyniak, Melanie Doyle-Eisele, James E. Huckle, Raymond A. Guilmette, Matthew P. Sadgrove, Marina G.D. Leed, Waylon Weber

Publikováno v: International journal of radiation biology. 91(7)

Currently two injectable products of diethylenetriaminepentaacetic acid (DTPA) are U.S. Food and Drug Administration (FDA)-approved for decorporation of (241)Am; however, an oral product is considered more amenable in a mass casualty situation. The d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cd297a2a8e2954d59b06777bbe0922
https://pubmed.ncbi.nlm.nih.gov/25912343

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Orally administered DTPA penta-ethyl ester for the decorporation of inhaled 241Am

Autor: Michael Jay, Waylon Weber, Melanie Doyle-Eisele, Katsuhiko Sueda, James E. Huckle, Matthew P. Sadgrove, Marina G.D. Leed, Raymond A. Guilmette

Diethylenetriaminepentaacetic acid (DTPA) is an effective decorporation agent to facilitate the elimination of radionuclides from the body, but its permeability-limited oral bioavailability limits its utility in mass-casualty emergencies. To overcome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a067bcdd9887aba306ae700e4ff34848
https://europepmc.org/articles/PMC4001124/

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Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-β-cyclodextrin

Autor: Marina G.D. Leed, Catheleeya Mekjaruskul, Matthew P. Sadgrove, Yu Tsai Yang, Michael Jay, Bungorn Sripanidkulchai

Publikováno v: International journal of pharmaceutics. 445(1-2)

The Kaempferia parviflora (KP) plant contains several methoxyflavones including 5,7-dimethoxyflavone (DMF), 5,7,4'-trimethoxyflavone (TMF), and 3,5,7,3',4'-pentamethoxyflavone (PMF). Ethanolic extracts of KP have shown various pharmacological effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e39fc38b6ead91d34abfc4623e2780
https://pubmed.ncbi.nlm.nih.gov/23376503

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